Search Keyword:


Search option:


IID01012
 UniprotQ9BXH1
ProteinBcl-2-binding component 3, isoforms 1/2
GeneBBC3
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
193
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 92-193
 Evidence NMR¸ CD Circular dichroism (CD) and NMR indicated that PUMA beta, the smallest of two splicing variants containing a functional BH3 domain, was intrinsically disordered. Reference
       Region 92-193 disorder
Seq 127-149 Hetero dimer : IID00970Complex
 Evidence X-RAY 6qfm B Reference
       Region 6qfm B 127-130 disorder
       Region 6qfm B 131-149 order
Seq 127-149 Hetero dimer :
 Evidence X-RAY 6qg8 B Reference
       Region 6qg8 B 127-128 disorder
       Region 6qg8 B 129-147 order
       Region 6qg8 B 148-149 disorder
Seq 130-154 Hetero trimer : IID00720Complex
 Evidence X-RAY 4hnj C Reference
       Region 4hnj C 130-130 disorder
       Region 4hnj C 131-152 order
       Region 4hnj C 153-154 disorder
Seq 130-154 Hetero dimer : IID00720Complex
 Evidence NMR 2m04 B Reference
       Region 2m04 B 130-154 order
       Region 2m04 B 154-154 high_rmsd
Seq 130-155 Hetero dimer : P03182
 Evidence X-RAY 7p9w B Reference
       Region 7p9w B 130-130 disorder
       Region 7p9w B 131-151 order
       Region 7p9w B 152-155 disorder
Seq 130-155 Hetero tetramer : A0A0R8HV90
 Evidence X-RAY 7p0s C Reference
       Region 7p0s C 130-132 disorder
       Region 7p0s C 133-155 order
 Evidence X-RAY 7p0s U Reference
       Region 7p0s U 130-131 disorder
       Region 7p0s U 132-155 order
Seq 130-155 Hetero dimer : Q76RI8
 Evidence X-RAY 7qtx B Reference
       Region 7qtx B 130-130 disorder
       Region 7qtx B 131-155 order
Seq 130-155 Hetero dimer : Q9DHU6
 Evidence X-RAY 6tqp B Reference
       Region 6tqp B 130-155 order
Seq 132-154 Hetero dimer : Q16548
 Evidence X-RAY 5uul B Reference
       Region 5uul B 132-154 order
Seq 134-152 Hetero tetramer : IID00720Complex
 Evidence X-RAY 4bpk C Reference
       Region 4bpk C 134-139 order
       Region 4bpk C 140-140 disorder
       Region 4bpk C 141-152 order
 Evidence X-RAY 4bpk D Reference
       Region 4bpk D 134-139 order
       Region 4bpk D 140-140 disorder
       Region 4bpk D 141-152 order
Seq 136-150 Hetero pentamer : IID00015Complex
 Evidence X-RAY 7dvd E Reference
       Region 7dvd E 136-150 order
Seq 136-152 Hetero hexamer : IID00970Complex,P97287
 Evidence X-RAY 4bpi B Reference
       Region 4bpi B 136-139 order
       Region 4bpi B 140-140 disorder
       Region 4bpi B 141-152 order
Seq 139-153 Hetero hexamer : IID00970Complex,P97287
 Evidence X-RAY 4bpj D Reference
       Region 4bpj D 139-139 order
       Region 4bpj D 140-140 disorder
       Region 4bpj D 141-153 order
SeqProS verified 130-153 The residues with high_rmsd are excluded from the ProS. Hetero dimer : IID00720Complex
       Region 2m04 B 130-154 order
       Region 92-193 disorder
SeqProS verified 130-155 Hetero dimer : Q9DHU6
       Region 6tqp B 130-155 order
       Region 92-193 disorder
SeqProS verified 131-151 Hetero dimer : P03182
       Region 7p9w B 131-151 order
       Region 92-193 disorder
SeqProS verified 131-151 Hetero dimer : Q76RI8
       Region 7qtx B 131-155 order
       Region 92-193 disorder
SeqProS verified 131-152 Hetero trimer : IID00720Complex
       Region 4hnj C 131-152 order
       Region 92-193 disorder
SeqProS verified 132-154 Hetero dimer : Q16548
       Region 5uul B 132-154 order
       Region 92-193 disorder
SeqProS verified 132-155 Hetero tetramer : A0A0R8HV90
       Region 7p0s C 133-155 order
       Region 7p0s U 132-155 order
       Region 92-193 disorder
SeqProS verified 136-150 Hetero pentamer : IID00015Complex
       Region 7dvd E 136-150 order
       Region 92-193 disorder
Seqphosphorylation
    10-10 Phosphoserine
 
Prediction
NeProc
Disorder 1-20,28-37,43-133,162-165,177-193
Order 21-27,38-42,134-161,166-176
ProS 1-5,13-20,28-37,55-60,68-91,129-133,177-193
AlphaFold
Disorder 1-127,163-165,179-193
Order 128-162,166-178
SEG 44-71 ,73-96 ,153-162
Function
Function in SwissProt
Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (PubMed:11463391, PubMed:23340338). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (PubMed:23340338). Regulates ER stress-induced neuronal apoptosis (By similarity).
Biological Process
Diagram with PDB data
BBC3/BCL2L1Solution structure of BCL-xL in complex with PUMA BH3 peptide