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IID01013
 UniprotQ9BXW4
ProteinMicrotubule-associated proteins 1A/1B light chain 3C
GeneMAP1LC3C
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
147
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-126 Hetero dimer : IID00972Complex
 Evidence X-RAY 3vvw B Reference
       Region 3vvw B 1-12 disorder
       Region 3vvw B 13-126 order
Seq 1-126 Monomer :
 Evidence NMR 2ncn A Reference
       Region 2ncn A 1-126 order
       Region 2ncn A 1-15 high_rmsd
       Region 2ncn A 123-126 high_rmsd
 Evidence X-RAY 3wam A Reference
       Region 3wam A 8-10 disorder
       Region 3wam A 11-125 order
Seq 8-125 Hetero dimer : IID00917Complex
 Evidence X-RAY 3wap A Reference
       Region 3wap A 8-125 order
Seq 8-125 Hetero dimer : IID01034Complex
 Evidence X-RAY 5dpw A Reference
       Region 5dpw A 8-10 disorder
       Region 5dpw A 11-125 order
 Evidence X-RAY 5dpw C Reference
       Region 5dpw C 8-10 disorder
       Region 5dpw C 11-125 order
 Evidence X-RAY 5dpw E Reference
       Region 5dpw E 8-10 disorder
       Region 5dpw E 11-125 order
 Evidence X-RAY 5dpw G Reference
       Region 5dpw G 8-10 disorder
       Region 5dpw G 11-125 order
 Evidence X-RAY 5dpw I Reference
       Region 5dpw I 8-10 disorder
       Region 5dpw I 11-125 order
 Evidence X-RAY 5dpw K Reference
       Region 5dpw K 8-10 disorder
       Region 5dpw K 11-125 order
 Evidence X-RAY 5dpw M Reference
       Region 5dpw M 8-10 disorder
       Region 5dpw M 11-125 order
 Evidence X-RAY 5dpw O Reference
       Region 5dpw O 8-10 disorder
       Region 5dpw O 11-125 order
 
Prediction
NeProc
Disorder 1-11,130-147
Order 12-96,101-129
ProS 137-147
AlphaFold
Disorder 1-11,93-95,126-147
Order 12-92,96-125
Function
Function in SwissProt
Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2 (PubMed:23022382). Recruits all ATG8 family members to infecting bacteria such as S.typhimurium (PubMed:23022382). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins (PubMed:28404643).