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IID01017
 UniprotQ9H0R8
ProteinGamma-aminobutyric acid receptor-associated protein-like 1
GeneGABARAPL1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
117
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-117 Hetero dimer : IID00347Complex
 Evidence X-RAY 5lxh A Reference
       Region 5lxh A 1-114 order
       Region 5lxh A 115-117 disorder
 Evidence X-RAY 5lxh B Reference
       Region 5lxh B 1-115 order
       Region 5lxh B 116-117 disorder
 Evidence X-RAY 5lxh C Reference
       Region 5lxh C 1-36 order
       Region 5lxh C 37-39 disorder
       Region 5lxh C 40-117 order
Seq 1-117 Hetero tetramer : IID00987Complex
 Evidence X-RAY 6hol A Reference
       Region 6hol A 1-1 disorder
       Region 6hol A 2-117 order
 Evidence X-RAY 6hol B Reference
       Region 6hol B 1-1 disorder
       Region 6hol B 2-117 order
Seq 1-117 Hetero dimer : IID01036Complex
 Evidence X-RAY 6yoo A Reference
       Region 6yoo A 1-117 order
Seq 1-117 Hetero tetramer : Q9UIL1
 Evidence X-RAY 7aa7 A Reference
       Region 7aa7 A 1-115 order
       Region 7aa7 A 116-117 disorder
 Evidence X-RAY 7aa7 B Reference
       Region 7aa7 B 1-114 order
       Region 7aa7 B 115-117 disorder
Seq 1-117 Hetero tetramer : IID00669Complex
 Evidence X-RAY 6hoi A Reference
       Region 6hoi A 1-117 order
 Evidence X-RAY 6hoi B Reference
       Region 6hoi B 1-117 order
Seq 1-117 Hetero dodecamer :
 Evidence X-RAY 7aa9 A Reference
       Region 7aa9 A 1-117 order
 Evidence X-RAY 7aa9 C Reference
       Region 7aa9 C 1-117 order
 Evidence X-RAY 7aa9 E Reference
       Region 7aa9 E 1-117 order
 Evidence X-RAY 7aa9 G Reference
       Region 7aa9 G 1-117 order
 Evidence X-RAY 7aa9 I Reference
       Region 7aa9 I 1-115 order
       Region 7aa9 I 116-117 disorder
 Evidence X-RAY 7aa9 K Reference
       Region 7aa9 K 1-117 order
Seq 1-117 Hetero tetramer : IID00347Complex
 Evidence X-RAY 5lxi B Reference
       Region 5lxi B 1-116 order
       Region 5lxi B 117-117 disorder
 Evidence X-RAY 5lxi D Reference
       Region 5lxi D 1-117 order
Seq 1-117 Hetero tetramer : Q9HCE0
 Evidence X-RAY 7jhx A Reference
       Region 7jhx A 1-117 order
 Evidence X-RAY 7jhx B Reference
       Region 7jhx B 1-1 disorder
       Region 7jhx B 2-117 order
Seq 2-115 Hetero dimer : IID00977Complex
 Evidence NMR 2l8j A Reference
       Region 2l8j A 2-115 order
Seq 2-117 Hetero dimer : IID01034Complex
 Evidence X-RAY 5dpt A Reference
       Region 5dpt A 2-114 order
       Region 5dpt A 115-117 disorder
Seq 2-117 Hetero dimer : IID01034Complex
 Evidence X-RAY 5dpt B Reference
       Region 5dpt B 2-116 order
       Region 5dpt B 117-117 disorder
Seq 3-111 Homo dimer :
 Evidence X-RAY 2r2q A Reference
       Region 2r2q A 3-111 order
 Evidence X-RAY 2r2q B Reference
       Region 2r2q B 3-111 order
 
Prediction
NeProc
Disorder 114-117
Order 1-85,91-113
ProS 114-117
AlphaFold
Disorder 115-117
Order 1-114
Function
Function in SwissProt
Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor (PubMed:16431922). Involved in formation of autophagosomal vacuoles (PubMed:20404487). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20404487). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537).