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IID01018
 UniprotQ9H211
ProteinDNA replication factor Cdt1
GeneCDT1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
546
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-14 Hetero dodecamer : IID00022Complex
 Evidence X-RAY 6qcg G Reference
       Region 6qcg G 1-2 disorder
       Region 6qcg G 3-12 order
       Region 6qcg G 13-14 disorder
 Evidence X-RAY 6qcg H Reference
       Region 6qcg H 1-2 disorder
       Region 6qcg H 3-12 order
       Region 6qcg H 13-14 disorder
 Evidence X-RAY 6qcg I Reference
       Region 6qcg I 1-2 disorder
       Region 6qcg I 3-12 order
       Region 6qcg I 13-14 disorder
 Evidence X-RAY 6qcg J Reference
       Region 6qcg J 1-2 disorder
       Region 6qcg J 3-12 order
       Region 6qcg J 13-14 disorder
 Evidence X-RAY 6qcg K Reference
       Region 6qcg K 1-2 disorder
       Region 6qcg K 3-12 order
       Region 6qcg K 13-14 disorder
 Evidence X-RAY 6qcg L Reference
       Region 6qcg L 1-2 disorder
       Region 6qcg L 3-12 order
       Region 6qcg L 13-14 disorder
Seq 1-546 Hetero hexamer : IID00409Complex
 Evidence X-RAY 2wvr C Reference
       Region 2wvr C 1-166 disorder
       Region 2wvr C 167-252 order
       Region 2wvr C 253-267 disorder
       Region 2wvr C 268-353 order
       Region 2wvr C 354-546 disorder
Seq 413-440 Hetero dimer : IID00833Complex
 Evidence NMR 2le8 B Monomer structure adopts an amphipathic alpha-helical conformation (PMID=22140117). Reference
       Region 2le8 B 413-440 order
       Region 2le8 B 413-419 high_rmsd
       Region 2le8 B 436-440 high_rmsd
SeqProS verified 3-12 Hetero dodecamer : IID00022Complex
       Region 6qcg G 3-12 order
       Region 6qcg H 3-12 order
       Region 6qcg I 3-12 order
       Region 6qcg J 3-12 order
       Region 6qcg K 3-12 order
       Region 6qcg L 3-12 order
       Region 2wvr C 1-166 disorder
Seqphosphorylation
    29-29 Phosphothreonine; by MAPK8
    31-31 Phosphoserine
    93-93 Phosphoserine; by MAPK8
    318-318 Phosphoserine; by MAPK8
    380-380 Phosphoserine
    394-394 Phosphoserine
 
Prediction
NeProc
Disorder 1-183,278-286,349-450,542-546
Order 184-277,287-348,451-541
ProS 1-18,126-136,167-174,360-385,414-447,542-546
AlphaFold
Disorder 1-117,145-165,254-265,278-281,353-358,369-369,371-371,380-380,382-416,545-546
Order 118-144,166-253,266-277,282-352,359-368,370-370,372-379,381-381,417-544
SEG 11-23 ,28-45 ,48-71 ,378-415 ,442-457 ,499-512
Function
Function in SwissProt
Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212, PubMed:26842564). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity).