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IID01019
 UniprotQ9H492
ProteinMicrotubule-associated proteins 1A/1B light chain 3A
GeneMAP1LC3A
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
121
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-121 Hetero tetramer : IID01011Complex
 Evidence X-RAY 5cx3 A Reference
       Region 5cx3 A 1-2 disorder
       Region 5cx3 A 3-121 order
 Evidence X-RAY 5cx3 C Reference
       Region 5cx3 C 1-2 disorder
       Region 5cx3 C 3-121 order
 Evidence X-RAY 5cx3 B Reference
       Region 5cx3 B 1-3 disorder
       Region 5cx3 B 4-121 order
 Evidence X-RAY 5cx3 D Reference
       Region 5cx3 D 1-4 disorder
       Region 5cx3 D 5-121 order
Seq 1-121 Monomer :
 Evidence X-RAY 3eci A Reference
       Region 3eci A 1-4 disorder
       Region 3eci A 5-116 order
       Region 3eci A 117-121 disorder
 Evidence X-RAY 3eci B Reference
       Region 3eci B 1-4 disorder
       Region 3eci B 5-116 order
       Region 3eci B 117-121 disorder
 Evidence X-RAY 3wal A Reference
       Region 3wal A 2-4 disorder
       Region 3wal A 5-119 order
       Region 3wal A 120-121 disorder
 Evidence X-RAY 4zdv A Reference
       Region 4zdv A 2-119 order
       Region 4zdv A 120-120 disorder
 Evidence X-RAY 6tbe A Reference
       Region 6tbe A 4-118 order
       Region 6tbe A 119-119 disorder
 Evidence X-RAY 7r9w A Reference
       Region 7r9w A 1-3 disorder
       Region 7r9w A 4-118 order
       Region 7r9w A 119-120 disorder
 Evidence X-RAY 7r9z A Reference
       Region 7r9z A 1-3 disorder
       Region 7r9z A 4-118 order
       Region 7r9z A 119-120 disorder
 Evidence X-RAY 7ra0 A Reference
       Region 7ra0 A 1-3 disorder
       Region 7ra0 A 4-118 order
       Region 7ra0 A 119-120 disorder
Seq 2-121 Hetero dimer : IID01034Complex
 Evidence X-RAY 5dpr B Reference
       Region 5dpr B 2-121 order
Seq 2-121 Hetero dimer : IID01034Complex
 Evidence X-RAY 5dpr A Reference
       Region 5dpr A 2-118 order
       Region 5dpr A 119-121 disorder
Seq 2-121 Hetero dimer : IID01034Complex
 Evidence X-RAY 5dpr C Reference
       Region 5dpr C 2-121 order
Seq 2-121 Hetero dimer : IID01034Complex
 Evidence X-RAY 5dpr D Reference
       Region 5dpr D 2-118 order
       Region 5dpr D 119-121 disorder
Seq 2-121 Hetero tetramer : IID00917Complex
 Evidence X-RAY 3wan A Reference
       Region 3wan A 2-119 order
       Region 3wan A 120-121 disorder
 Evidence X-RAY 3wan B Reference
       Region 3wan B 2-121 order
Seqphosphorylation
    12-12 Phosphoserine; by PKA
 
Prediction
NeProc
Disorder 1-6
Order 7-89,95-121
AlphaFold
Disorder 1-3,87-87,119-121
Order 4-86,88-118
Function
Function in SwissProt
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537).