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IID01020
 UniprotQ9H6L5
ProteinReticulophagy regulator 1
GeneRETREG1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
497
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 450-468 Hetero dimer : IID00921Complex
 Evidence X-RAY 7brq A Reference
       Region 7brq A 450-452 disorder
       Region 7brq A 453-468 order
Seq 451-476 Hetero dimer : IID50471Complex
 Evidence X-RAY 7fb5 B Reference
       Region 7fb5 B 451-452 disorder
       Region 7fb5 B 453-473 order
       Region 7fb5 B 474-476 disorder
 
Prediction
NeProc
Disorder 1-66,259-497
Order 67-258
ProS 259-274,284-300,315-323,342-355,378-382,404-420,452-473,487-497
AlphaFold
Disorder 1-33,36-37,39-40,43-43,45-91,111-111,113-116,118-119,136-136,138-143,154-168,170-170,188-188,190-191,231-236,238-238,255-255,271-402,404-404,428-454,471-497
Order 34-35,38-38,41-42,44-44,92-110,112-112,117-117,120-135,137-137,144-153,169-169,171-187,189-189,192-230,237-237,239-254,256-270,403-403,405-427,455-470
SEG 4-67 ,219-233 ,444-459
Function
Function in SwissProt
Endoplasmic reticulum (ER)-anchored autophagy regulator which mediates ER delivery into lysosomes through sequestration into autophagosomes (PubMed:26040720, PubMed:31930741, PubMed:34338405). Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins (PubMed:26040720, PubMed:31930741, PubMed:34338405). Active under basal conditions (PubMed:34338405). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Required for long-term survival of nociceptive and autonomic ganglion neurons (PubMed:19838196, PubMed:26040720).
(Microbial infection) During SARS-CoV-2 infection, RETREG1-mediated reticulophagy is promoted by SARS-CoV-2 ORF3A protein (PubMed:35239449). This induces endoplasmic reticulum stress and inflammatory responses and facilitates viral infection (PubMed:35239449).