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IID01021
 UniprotQ9H6S1
Protein5-azacytidine-induced protein 2
GeneAZI2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
392
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 6-16 Hetero tetramer : IID00998Complex
 Evidence X-RAY 7ea2 A Reference
       Region 7ea2 A 6-16 order
 Evidence X-RAY 7ea2 B Reference
       Region 7ea2 B 6-16 order
Seq 6-16 Hetero trimer : IID00921Complex
 Evidence X-RAY 7ea7 C Reference
       Region 7ea7 C 6-6 disorder
       Region 7ea7 C 7-14 order
       Region 7ea7 C 15-16 disorder
Seq 33-75 Hetero tetramer : IID00991Complex
 Evidence X-RAY 5z7g C Reference
       Region 5z7g C 33-75 order
 Evidence X-RAY 5z7g D Reference
       Region 5z7g D 33-75 order
Seq 33-75 Hetero tetramer : IID00972Complex
 Evidence X-RAY 5z7l C Reference
       Region 5z7l C 33-75 order
 Evidence X-RAY 5z7l D Reference
       Region 5z7l D 33-75 order
Seq 215-255 Hetero dimer : Q9UHD2
 Evidence X-RAY 5ep6 A Reference
       Region 5ep6 A 215-250 order
       Region 5ep6 A 251-255 disorder
 Evidence X-RAY 5ep6 C Reference
       Region 5ep6 C 215-249 order
       Region 5ep6 C 250-255 disorder
Seqphosphorylation
    353-353 Phosphoserine
    318-318 Phosphoserine
 
Prediction
NeProc
Disorder 1-36,44-44,80-102,149-161,197-227,251-358
Order 37-43,45-79,103-148,162-196,228-250,359-392
ProS 4-29,44-44,86-102,149-161,206-227,262-269,318-323,329-340,345-358
AlphaFold
Disorder 1-6,11-11,13-34,79-83,154-157,196-214,249-349,351-351,353-354,356-392
Order 7-10,12-12,35-78,84-153,158-195,215-248,350-350,352-352,355-355
SEG 370-378
Function
Function in SwissProt
Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (PubMed:14560022, PubMed:21931631). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (PubMed:14560022, PubMed:21931631). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (PubMed:14560022, PubMed:21931631). Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B (PubMed:14560022, PubMed:21931631). Participates in IFNB promoter activation via TICAM1 (PubMed:15611223).