Search Keyword:


Search option:


IID01025
 UniprotQ9NYV4
ProteinCyclin-dependent kinase 12
GeneCDK12
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1490
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bui B Reference
       Region 8bui B 712-714 disorder
       Region 8bui B 715-1041 order
       Region 8bui B 1042-1051 disorder
 Evidence X-RAY 8bui E Reference
       Region 8bui E 712-714 disorder
       Region 8bui E 715-1039 order
       Region 8bui E 1040-1051 disorder
 Evidence X-RAY 8bui H Reference
       Region 8bui H 712-714 disorder
       Region 8bui H 715-1038 order
       Region 8bui H 1039-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8buo B Reference
       Region 8buo B 712-714 disorder
       Region 8buo B 715-1040 order
       Region 8buo B 1041-1051 disorder
 Evidence X-RAY 8buo E Reference
       Region 8buo E 712-714 disorder
       Region 8buo E 715-1040 order
       Region 8buo E 1041-1051 disorder
 Evidence X-RAY 8buo H Reference
       Region 8buo H 712-714 disorder
       Region 8buo H 715-1044 order
       Region 8buo H 1045-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 6td3 B Reference
       Region 6td3 B 712-714 disorder
       Region 6td3 B 715-1047 order
       Region 6td3 B 1048-1051 disorder
 Evidence X-RAY 6td3 E Reference
       Region 6td3 E 712-714 disorder
       Region 6td3 E 715-1047 order
       Region 6td3 E 1048-1051 disorder
 Evidence X-RAY 6td3 H Reference
       Region 6td3 H 712-714 disorder
       Region 6td3 H 715-1047 order
       Region 6td3 H 1048-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8buc B Reference
       Region 8buc B 712-714 disorder
       Region 8buc B 715-1041 order
       Region 8buc B 1042-1051 disorder
 Evidence X-RAY 8buc E Reference
       Region 8buc E 712-714 disorder
       Region 8buc E 715-1039 order
       Region 8buc E 1040-1051 disorder
 Evidence X-RAY 8buc H Reference
       Region 8buc H 712-714 disorder
       Region 8buc H 715-1044 order
       Region 8buc H 1045-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bu5 B Reference
       Region 8bu5 B 712-712 disorder
       Region 8bu5 B 713-1044 order
       Region 8bu5 B 1045-1051 disorder
 Evidence X-RAY 8bu5 E Reference
       Region 8bu5 E 712-712 disorder
       Region 8bu5 E 713-1043 order
       Region 8bu5 E 1044-1051 disorder
 Evidence X-RAY 8bu5 H Reference
       Region 8bu5 H 712-712 disorder
       Region 8bu5 H 713-1043 order
       Region 8bu5 H 1044-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bua B Reference
       Region 8bua B 712-714 disorder
       Region 8bua B 715-1039 order
       Region 8bua B 1040-1051 disorder
 Evidence X-RAY 8bua E Reference
       Region 8bua E 712-714 disorder
       Region 8bua E 715-1033 order
       Region 8bua E 1034-1051 disorder
 Evidence X-RAY 8bua H Reference
       Region 8bua H 712-714 disorder
       Region 8bua H 715-1034 order
       Region 8bua H 1035-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bug B Reference
       Region 8bug B 712-714 disorder
       Region 8bug B 715-1041 order
       Region 8bug B 1042-1051 disorder
 Evidence X-RAY 8bug E Reference
       Region 8bug E 712-714 disorder
       Region 8bug E 715-1039 order
       Region 8bug E 1040-1051 disorder
 Evidence X-RAY 8bug H Reference
       Region 8bug H 712-714 disorder
       Region 8bug H 715-1039 order
       Region 8bug H 1040-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8buj B Reference
       Region 8buj B 712-714 disorder
       Region 8buj B 715-1041 order
       Region 8buj B 1042-1051 disorder
 Evidence X-RAY 8buj E Reference
       Region 8buj E 712-714 disorder
       Region 8buj E 715-1043 order
       Region 8buj E 1044-1051 disorder
 Evidence X-RAY 8buj H Reference
       Region 8buj H 712-714 disorder
       Region 8buj H 715-1043 order
       Region 8buj H 1044-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bu7 B Reference
       Region 8bu7 B 712-714 disorder
       Region 8bu7 B 715-1043 order
       Region 8bu7 B 1044-1051 disorder
 Evidence X-RAY 8bu7 E Reference
       Region 8bu7 E 712-714 disorder
       Region 8bu7 E 715-1043 order
       Region 8bu7 E 1044-1051 disorder
 Evidence X-RAY 8bu7 H Reference
       Region 8bu7 H 712-714 disorder
       Region 8bu7 H 715-1043 order
       Region 8bu7 H 1044-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bue B Reference
       Region 8bue B 712-714 disorder
       Region 8bue B 715-1043 order
       Region 8bue B 1044-1051 disorder
 Evidence X-RAY 8bue E Reference
       Region 8bue E 712-714 disorder
       Region 8bue E 715-1039 order
       Region 8bue E 1040-1051 disorder
 Evidence X-RAY 8bue H Reference
       Region 8bue H 712-714 disorder
       Region 8bue H 715-1043 order
       Region 8bue H 1044-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8buq B Reference
       Region 8buq B 712-714 disorder
       Region 8buq B 715-796 order
       Region 8buq B 797-800 disorder
       Region 8buq B 801-1039 order
       Region 8buq B 1040-1051 disorder
 Evidence X-RAY 8buq E Reference
       Region 8buq E 712-714 disorder
       Region 8buq E 715-1027 order
       Region 8buq E 1028-1051 disorder
 Evidence X-RAY 8buq H Reference
       Region 8buq H 712-714 disorder
       Region 8buq H 715-1035 order
       Region 8buq H 1036-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bu3 B Reference
       Region 8bu3 B 712-714 disorder
       Region 8bu3 B 715-1040 order
       Region 8bu3 B 1041-1051 disorder
 Evidence X-RAY 8bu3 E Reference
       Region 8bu3 E 712-714 disorder
       Region 8bu3 E 715-1039 order
       Region 8bu3 E 1040-1051 disorder
 Evidence X-RAY 8bu3 H Reference
       Region 8bu3 H 712-714 disorder
       Region 8bu3 H 715-1044 order
       Region 8bu3 H 1045-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bu1 B Reference
       Region 8bu1 B 712-714 disorder
       Region 8bu1 B 715-1044 order
       Region 8bu1 B 1045-1051 disorder
 Evidence X-RAY 8bu1 E Reference
       Region 8bu1 E 712-714 disorder
       Region 8bu1 E 715-1044 order
       Region 8bu1 E 1045-1051 disorder
 Evidence X-RAY 8bu1 H Reference
       Region 8bu1 H 712-714 disorder
       Region 8bu1 H 715-1044 order
       Region 8bu1 H 1045-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bu6 B Reference
       Region 8bu6 B 712-714 disorder
       Region 8bu6 B 715-1039 order
       Region 8bu6 B 1040-1051 disorder
 Evidence X-RAY 8bu6 E Reference
       Region 8bu6 E 712-714 disorder
       Region 8bu6 E 715-1038 order
       Region 8bu6 E 1039-1051 disorder
 Evidence X-RAY 8bu6 H Reference
       Region 8bu6 H 712-714 disorder
       Region 8bu6 H 715-1038 order
       Region 8bu6 H 1039-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8buk B Reference
       Region 8buk B 712-714 disorder
       Region 8buk B 715-1040 order
       Region 8buk B 1041-1051 disorder
 Evidence X-RAY 8buk E Reference
       Region 8buk E 712-714 disorder
       Region 8buk E 715-1039 order
       Region 8buk E 1040-1051 disorder
 Evidence X-RAY 8buk H Reference
       Region 8buk H 712-714 disorder
       Region 8buk H 715-1044 order
       Region 8buk H 1045-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bub B Reference
       Region 8bub B 712-714 disorder
       Region 8bub B 715-1041 order
       Region 8bub B 1042-1051 disorder
 Evidence X-RAY 8bub E Reference
       Region 8bub E 712-714 disorder
       Region 8bub E 715-1043 order
       Region 8bub E 1044-1051 disorder
 Evidence X-RAY 8bub H Reference
       Region 8bub H 712-714 disorder
       Region 8bub H 715-1044 order
       Region 8bub H 1045-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bup B Reference
       Region 8bup B 712-714 disorder
       Region 8bup B 715-1027 order
       Region 8bup B 1028-1051 disorder
 Evidence X-RAY 8bup E Reference
       Region 8bup E 712-714 disorder
       Region 8bup E 715-1027 order
       Region 8bup E 1028-1051 disorder
 Evidence X-RAY 8bup H Reference
       Region 8bup H 712-714 disorder
       Region 8bup H 715-1028 order
       Region 8bup H 1029-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8buh B Reference
       Region 8buh B 712-714 disorder
       Region 8buh B 715-1039 order
       Region 8buh B 1040-1051 disorder
 Evidence X-RAY 8buh E Reference
       Region 8buh E 712-714 disorder
       Region 8buh E 715-1034 order
       Region 8buh E 1035-1051 disorder
 Evidence X-RAY 8buh H Reference
       Region 8buh H 712-714 disorder
       Region 8buh H 715-1033 order
       Region 8buh H 1034-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bu9 B Reference
       Region 8bu9 B 712-714 disorder
       Region 8bu9 B 715-1039 order
       Region 8bu9 B 1040-1051 disorder
 Evidence X-RAY 8bu9 E Reference
       Region 8bu9 E 712-714 disorder
       Region 8bu9 E 715-1039 order
       Region 8bu9 E 1040-1051 disorder
 Evidence X-RAY 8bu9 H Reference
       Region 8bu9 H 712-714 disorder
       Region 8bu9 H 715-1038 order
       Region 8bu9 H 1039-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bur B Reference
       Region 8bur B 712-714 disorder
       Region 8bur B 715-1044 order
       Region 8bur B 1045-1051 disorder
 Evidence X-RAY 8bur E Reference
       Region 8bur E 712-714 disorder
       Region 8bur E 715-1040 order
       Region 8bur E 1041-1051 disorder
 Evidence X-RAY 8bur H Reference
       Region 8bur H 712-714 disorder
       Region 8bur H 715-1039 order
       Region 8bur H 1040-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bun B Reference
       Region 8bun B 712-714 disorder
       Region 8bun B 715-1041 order
       Region 8bun B 1042-1051 disorder
 Evidence X-RAY 8bun E Reference
       Region 8bun E 712-714 disorder
       Region 8bun E 715-1039 order
       Region 8bun E 1040-1051 disorder
 Evidence X-RAY 8bun H Reference
       Region 8bun H 712-714 disorder
       Region 8bun H 715-1043 order
       Region 8bun H 1044-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8but B Reference
       Region 8but B 712-714 disorder
       Region 8but B 715-1039 order
       Region 8but B 1040-1051 disorder
 Evidence X-RAY 8but E Reference
       Region 8but E 712-714 disorder
       Region 8but E 715-1039 order
       Region 8but E 1040-1051 disorder
 Evidence X-RAY 8but H Reference
       Region 8but H 712-714 disorder
       Region 8but H 715-1043 order
       Region 8but H 1044-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8buf B Reference
       Region 8buf B 712-714 disorder
       Region 8buf B 715-1033 order
       Region 8buf B 1034-1051 disorder
 Evidence X-RAY 8buf E Reference
       Region 8buf E 712-714 disorder
       Region 8buf E 715-1043 order
       Region 8buf E 1044-1051 disorder
 Evidence X-RAY 8buf H Reference
       Region 8buf H 712-714 disorder
       Region 8buf H 715-1032 order
       Region 8buf H 1033-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bus B Reference
       Region 8bus B 712-714 disorder
       Region 8bus B 715-1039 order
       Region 8bus B 1040-1051 disorder
 Evidence X-RAY 8bus E Reference
       Region 8bus E 712-714 disorder
       Region 8bus E 715-1043 order
       Region 8bus E 1044-1051 disorder
 Evidence X-RAY 8bus H Reference
       Region 8bus H 712-714 disorder
       Region 8bus H 715-1044 order
       Region 8bus H 1045-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bud B Reference
       Region 8bud B 712-714 disorder
       Region 8bud B 715-1043 order
       Region 8bud B 1044-1051 disorder
 Evidence X-RAY 8bud E Reference
       Region 8bud E 712-714 disorder
       Region 8bud E 715-1043 order
       Region 8bud E 1044-1051 disorder
 Evidence X-RAY 8bud H Reference
       Region 8bud H 712-714 disorder
       Region 8bud H 715-1043 order
       Region 8bud H 1044-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bu2 B Reference
       Region 8bu2 B 712-714 disorder
       Region 8bu2 B 715-1041 order
       Region 8bu2 B 1042-1051 disorder
 Evidence X-RAY 8bu2 E Reference
       Region 8bu2 E 712-714 disorder
       Region 8bu2 E 715-1039 order
       Region 8bu2 E 1040-1051 disorder
 Evidence X-RAY 8bu2 H Reference
       Region 8bu2 H 712-714 disorder
       Region 8bu2 H 715-1043 order
       Region 8bu2 H 1044-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bum B Reference
       Region 8bum B 712-714 disorder
       Region 8bum B 715-1040 order
       Region 8bum B 1041-1051 disorder
 Evidence X-RAY 8bum E Reference
       Region 8bum E 712-714 disorder
       Region 8bum E 715-1039 order
       Region 8bum E 1040-1051 disorder
 Evidence X-RAY 8bum H Reference
       Region 8bum H 712-714 disorder
       Region 8bum H 715-1039 order
       Region 8bum H 1040-1051 disorder
Seq 712-1051 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bu4 B Reference
       Region 8bu4 B 712-714 disorder
       Region 8bu4 B 715-1043 order
       Region 8bu4 B 1044-1051 disorder
 Evidence X-RAY 8bu4 E Reference
       Region 8bu4 E 712-714 disorder
       Region 8bu4 E 715-1039 order
       Region 8bu4 E 1040-1051 disorder
 Evidence X-RAY 8bu4 H Reference
       Region 8bu4 H 712-714 disorder
       Region 8bu4 H 715-1044 order
       Region 8bu4 H 1045-1051 disorder
Seq 712-1052 Hetero dodecamer : IID00695Complex,IID00840Complex
 Evidence X-RAY 8bul B Reference
       Region 8bul B 712-714 disorder
       Region 8bul B 715-1039 order
       Region 8bul B 1040-1052 disorder
 Evidence X-RAY 8bul E Reference
       Region 8bul E 712-714 disorder
       Region 8bul E 715-1038 order
       Region 8bul E 1039-1052 disorder
 Evidence X-RAY 8bul H Reference
       Region 8bul H 712-714 disorder
       Region 8bul H 715-1034 order
       Region 8bul H 1035-1052 disorder
Seq 714-1063 Hetero tetramer : IID00695Complex
 Evidence X-RAY 4nst A Reference
       Region 4nst A 714-715 disorder
       Region 4nst A 716-798 order
       Region 4nst A 799-806 disorder
       Region 4nst A 807-1046 order
       Region 4nst A 1047-1063 disorder
 Evidence X-RAY 4nst C Reference
       Region 4nst C 714-716 disorder
       Region 4nst C 717-796 order
       Region 4nst C 797-806 disorder
       Region 4nst C 807-886 order
       Region 4nst C 887-887 disorder
       Region 4nst C 888-1045 order
       Region 4nst C 1046-1063 disorder
 Evidence X-RAY 7nxk A Reference
       Region 7nxk A 714-714 disorder
       Region 7nxk A 715-798 order
       Region 7nxk A 799-802 disorder
       Region 7nxk A 803-1040 order
       Region 7nxk A 1041-1063 disorder
 Evidence X-RAY 7nxk C Reference
       Region 7nxk C 714-716 disorder
       Region 7nxk C 717-796 order
       Region 7nxk C 797-806 disorder
       Region 7nxk C 807-1040 order
       Region 7nxk C 1041-1063 disorder
Seq 714-1063 Hetero tetramer : IID00695Complex
 Evidence X-RAY 6ckx A Reference
       Region 6ckx A 714-721 disorder
       Region 6ckx A 722-796 order
       Region 6ckx A 797-806 disorder
       Region 6ckx A 807-1024 order
       Region 6ckx A 1025-1063 disorder
 Evidence X-RAY 6ckx C Reference
       Region 6ckx C 714-721 disorder
       Region 6ckx C 722-796 order
       Region 6ckx C 797-806 disorder
       Region 6ckx C 807-1024 order
       Region 6ckx C 1025-1063 disorder
Seq 714-1063 Hetero dimer : IID00695Complex
 Evidence X-RAY 4cxa C Reference
       Region 4cxa C 715-717 disorder
       Region 4cxa C 718-1048 order
       Region 4cxa C 1049-1052 disorder
 Evidence X-RAY 4cxa A Reference
       Region 4cxa A 715-717 disorder
       Region 4cxa A 718-797 order
       Region 4cxa A 798-799 disorder
       Region 4cxa A 800-888 order
       Region 4cxa A 889-889 disorder
       Region 4cxa A 890-1050 order
       Region 4cxa A 1051-1052 disorder
 Evidence X-RAY 4un0 C Reference
       Region 4un0 C 715-718 disorder
       Region 4un0 C 719-796 order
       Region 4un0 C 797-803 disorder
       Region 4un0 C 804-974 order
       Region 4un0 C 975-976 disorder
       Region 4un0 C 977-1036 order
       Region 4un0 C 1037-1038 disorder
 Evidence X-RAY 4un0 D Reference
       Region 4un0 D 715-722 disorder
       Region 4un0 D 723-760 order
       Region 4un0 D 761-763 disorder
       Region 4un0 D 764-795 order
       Region 4un0 D 796-807 disorder
       Region 4un0 D 808-824 order
       Region 4un0 D 825-829 disorder
       Region 4un0 D 830-885 order
       Region 4un0 D 886-890 disorder
       Region 4un0 D 891-1024 order
       Region 4un0 D 1025-1038 disorder
 Evidence X-RAY 6b3e A Reference
       Region 6b3e A 717-796 order
       Region 6b3e A 797-806 disorder
       Region 6b3e A 807-1036 order
 Evidence X-RAY 6b3e C Reference
       Region 6b3e C 717-718 disorder
       Region 6b3e C 719-796 order
       Region 6b3e C 797-806 disorder
       Region 6b3e C 807-1036 order
 Evidence X-RAY 8p81 A Reference
       Region 8p81 A 714-715 disorder
       Region 8p81 A 716-1035 order
       Region 8p81 A 1036-1063 disorder
Seq 715-1052 Hetero tetramer : IID00695Complex
 Evidence X-RAY 5acb C Reference
       Region 5acb C 715-715 disorder
       Region 5acb C 716-1040 order
       Region 5acb C 1041-1052 disorder
 Evidence X-RAY 5acb D Reference
       Region 5acb D 715-717 disorder
       Region 5acb D 718-797 order
       Region 5acb D 798-801 disorder
       Region 5acb D 802-886 order
       Region 5acb D 887-889 disorder
       Region 5acb D 890-1044 order
       Region 5acb D 1045-1052 disorder
Seqphosphorylation
    57-57 Phosphothreonine
    73-73 Phosphotyrosine
    236-236 Phosphoserine
    249-249 Phosphoserine
    265-265 Phosphoserine
    274-274 Phosphoserine
    276-276 Phosphoserine
    301-301 Phosphoserine
    303-303 Phosphoserine
    310-310 Phosphoserine
    312-312 Phosphoserine
    318-318 Phosphoserine
    323-323 Phosphoserine
    325-325 Phosphoserine
    332-332 Phosphoserine
    333-333 Phosphoserine
    334-334 Phosphoserine
    338-338 Phosphoserine
    341-341 Phosphoserine
    343-343 Phosphoserine
    345-345 Phosphoserine
    383-383 Phosphoserine
    385-385 Phosphoserine
    400-400 Phosphoserine
    420-420 Phosphoserine
    423-423 Phosphoserine
    514-514 Phosphothreonine
    614-614 Phosphoserine
    644-644 Phosphoserine
    681-681 Phosphoserine
    685-685 Phosphoserine
    692-692 Phosphothreonine
    889-889 Phosphoserine
    893-893 Phosphothreonine
    1053-1053 Phosphoserine
    1083-1083 Phosphoserine
    1244-1244 Phosphothreonine
    1246-1246 Phosphothreonine
 
Prediction
NeProc
Disorder 1-705,1044-1144,1149-1490
Order 706-1043,1145-1148
ProS 1-10,65-84,629-637,666-678,699-705,1044-1050,1110-1125,1130-1144,1149-1155,1202-1218,1291-1308,1336-1345,1386-1417,1436-1445,1455-1490
AlphaFold
Disorder 1-398,414-718,761-765,799-800,802-804,1054-1111,1119-1120,1123-1147,1149-1490
Order 399-413,719-760,766-798,801-801,805-1053,1112-1118,1121-1122,1148-1148
SEG 8-19 ,24-32 ,40-51 ,74-86 ,107-120 ,126-144 ,168-183 ,215-228 ,287-385 ,407-413 ,514-571 ,577-593 ,601-616 ,627-637 ,665-684 ,1256-1280 ,1377-1388 ,1446-1456 ,1473-1489
Function
Function in SwissProt
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.