Search Keyword:


Search option:


IID01027
 UniprotQ9P289
ProteinSerine/threonine-protein kinase 26
GeneSTK26
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
416
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-300 Monomer :
 Evidence X-RAY 3ggf A Reference
       Region 3ggf A 1-16 disorder
       Region 3ggf A 17-166 order
       Region 3ggf A 167-175 disorder
       Region 3ggf A 176-300 order
 Evidence X-RAY 3ggf B Reference
       Region 3ggf B 1-17 disorder
       Region 3ggf B 18-166 order
       Region 3ggf B 167-176 disorder
       Region 3ggf B 177-297 order
       Region 3ggf B 298-300 disorder
Seq 1-300 Homo dimer :
 Evidence X-RAY 7b36 A Reference
       Region 7b36 A 1-17 disorder
       Region 7b36 A 18-32 order
       Region 7b36 A 33-33 disorder
       Region 7b36 A 34-166 order
       Region 7b36 A 167-180 disorder
       Region 7b36 A 181-300 order
 Evidence X-RAY 7b36 C Reference
       Region 7b36 C 1-16 disorder
       Region 7b36 C 17-32 order
       Region 7b36 C 33-34 disorder
       Region 7b36 C 35-166 order
       Region 7b36 C 167-179 disorder
       Region 7b36 C 180-194 order
       Region 7b36 C 195-195 disorder
       Region 7b36 C 196-299 order
       Region 7b36 C 300-300 disorder
Seq 18-297 Hetero dimer : IID01033Complex
 Evidence X-RAY 4fza B Reference
       Region 4fza B 18-297 order
 Evidence X-RAY 4fzf B Reference
       Region 4fzf B 18-33 order
       Region 4fzf B 34-35 disorder
       Region 4fzf B 36-297 order
Seq 18-297,323-327 Hetero trimer : IID01033Complex
 Evidence X-RAY 4fzd B Reference
       Region 4fzd B 18-170 order
       Region 4fzd B 171-176 disorder
       Region 4fzd B 177-297 order
 Evidence X-RAY 4fzd C Reference
       Region 4fzd C 323-327 order
Seq 314-325 Hetero tetramer : IID00061Complex
 Evidence X-RAY 5xy9 C Reference
       Region 5xy9 C 314-315 disorder
       Region 5xy9 C 316-325 order
 Evidence X-RAY 5xy9 D Reference
       Region 5xy9 D 314-315 disorder
       Region 5xy9 D 316-325 order
Seq 320-335 Hetero dimer : Q9Y3A3
 Evidence X-RAY 5yf4 B Reference
       Region 5yf4 B 320-322 disorder
       Region 5yf4 B 323-333 order
       Region 5yf4 B 334-335 disorder
Seq 325-416 Hetero dimer : Q9BUL8
 Evidence X-RAY 3w8i B Reference
       Region 3w8i B 346-408 order
       Region 3w8i B 409-416 disorder
 Evidence X-RAY 4geh B Reference
       Region 4geh B 325-344 disorder
       Region 4geh B 345-349 order
       Region 4geh B 350-350 disorder
       Region 4geh B 351-410 order
       Region 4geh B 411-413 disorder
 Evidence X-RAY 4geh D Reference
       Region 4geh D 325-343 disorder
       Region 4geh D 344-412 order
       Region 4geh D 413-413 disorder
SeqProS predicted 323-327 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero trimer : IID01033Complex
       Region 4fzd C 323-327 order
SeqProS predicted 323-333 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : Q9Y3A3
       Region 5yf4 B 323-333 order
Seqphosphorylation
    4-4 Phosphoserine
    178-178 Phosphothreonine; by autocatalysis
    300-300 Phosphoserine
    304-304 Phosphoserine
    306-306 Phosphoserine
    309-309 Phosphoserine
    325-325 Phosphoserine
    327-327 Phosphothreonine
    328-328 Phosphothreonine
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-17,294-363,411-416
Order 18-293,364-410
ProS 294-298,322-342,411-416
AlphaFold
Disorder 1-8,15-17,164-181,300-350,408-416
Order 9-14,18-163,182-299,351-407
SEG 51-71 ,300-317
Function
Function in SwissProt
Serine/threonine-protein kinase that acts as a mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux (PubMed:29232556).
Biological Process
Diagram with PDB data
STK26/CAB39Crystal structure of MST4-MO25 complex with WSF motif