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IID01029
 UniprotQ9ULG6
ProteinCell cycle progression protein 1
GeneCCPG1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
757
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 101-113 Hetero dimer : IID00998Complex
 Evidence X-RAY 7d0e B Reference
       Region 7d0e B 101-102 disorder
       Region 7d0e B 103-113 order
SeqProS predicted 103-113 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00998Complex
       Region 7d0e B 103-113 order
Seqphosphorylation
    186-186 Phosphoserine
 
Prediction
NeProc
Disorder 1-11,17-217,241-299,386-416,459-626,743-757
Order 12-16,218-240,300-385,417-458,627-742
ProS 1-11,17-37,64-66,93-113,214-217,241-287,386-403,415-416,459-567,602-626,743-749,754-757
AlphaFold
Disorder 1-215,230-259,261-274,343-343,406-418,458-489,491-492,496-496,499-499,542-628,630-630,643-644,712-719,736-757
Order 216-229,260-260,275-342,344-405,419-457,490-490,493-495,497-498,500-541,629-629,631-642,645-711,720-735
SEG 5-11 ,45-57 ,154-168 ,349-366 ,427-436 ,456-471
Function
Function in SwissProt
Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation.