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IID01030
 UniprotQ9UMX1
ProteinSuppressor of fused homolog
GeneSUFU
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
484
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-284,345-484 Hetero dimer : IID00774Complex
 Evidence X-RAY 4kmd A Reference
       Region 4kmd A 1-27 disorder
       Region 4kmd A 28-278 order
       Region 4kmd A 279-284 disorder
       Region 4kmd A 345-358 disorder
       Region 4kmd A 359-450 order
       Region 4kmd A 451-456 disorder
       Region 4kmd A 457-480 order
       Region 4kmd A 481-484 disorder
Seq 1-484 Monomer :
 Evidence X-RAY 4km8 A Reference
       Region 4km8 A 1-6 order
       Region 4km8 A 7-21 disorder
       Region 4km8 A 22-279 order
       Region 4km8 A 280-284 disorder
       Region 4km8 A 345-361 disorder
       Region 4km8 A 362-450 order
       Region 4km8 A 451-456 disorder
       Region 4km8 A 457-481 order
       Region 4km8 A 482-484 disorder
 Evidence X-RAY 4km9 A Reference
       Region 4km9 A 1-20 disorder
       Region 4km9 A 21-280 order
       Region 4km9 A 281-355 disorder
       Region 4km9 A 356-452 order
       Region 4km9 A 453-456 disorder
       Region 4km9 A 457-481 order
       Region 4km9 A 482-484 disorder
Seq 1-305,326-484 Homo dimer :
 Evidence X-RAY 4kmh A Reference
       Region 4kmh A 1-3 order
       Region 4kmh A 4-19 disorder
       Region 4kmh A 20-279 order
       Region 4kmh A 280-305 disorder
       Region 4kmh A 326-361 disorder
       Region 4kmh A 362-450 order
       Region 4kmh A 451-454 disorder
       Region 4kmh A 455-481 order
       Region 4kmh A 482-484 disorder
 Evidence X-RAY 4kmh B Reference
       Region 4kmh B 1-5 order
       Region 4kmh B 6-19 disorder
       Region 4kmh B 20-280 order
       Region 4kmh B 281-305 disorder
       Region 4kmh B 326-360 disorder
       Region 4kmh B 361-450 order
       Region 4kmh B 451-455 disorder
       Region 4kmh B 456-481 order
       Region 4kmh B 482-484 disorder
Seq 27-262 Homo tetramer :
 Evidence X-RAY 1m1l A Reference
       Region 1m1l A 27-262 order
 Evidence X-RAY 1m1l B Reference
       Region 1m1l B 27-262 order
 Evidence X-RAY 1m1l C Reference
       Region 1m1l C 27-28 disorder
       Region 1m1l C 29-262 order
 Evidence X-RAY 1m1l D Reference
       Region 1m1l D 27-28 disorder
       Region 1m1l D 29-262 order
Seq 32-483 Hetero tetramer : IID90020Complex
 Evidence X-RAY 4bl8 A Reference
       Region 4bl8 A 32-278 order
       Region 4bl8 A 279-360 disorder
       Region 4bl8 A 361-449 order
       Region 4bl8 A 450-454 disorder
       Region 4bl8 A 455-478 order
       Region 4bl8 A 479-483 disorder
 Evidence X-RAY 4bl8 B Reference
       Region 4bl8 B 32-278 order
       Region 4bl8 B 279-360 disorder
       Region 4bl8 B 361-449 order
       Region 4bl8 B 450-453 disorder
       Region 4bl8 B 454-480 order
       Region 4bl8 B 481-483 disorder
Seq 32-278,361-483 Hetero trimer : IID90020Complex
 Evidence X-RAY 4bla A Reference
       Region 4bla A 32-278 order
       Region 4bla A 361-448 order
       Region 4bla A 449-454 disorder
       Region 4bla A 455-481 order
       Region 4bla A 482-483 disorder
Seq 32-278,361-453,457-483 Hetero hexadecamer : IID00774Complex,IID90020Complex
 Evidence X-RAY 4blb A Reference
       Region 4blb A 32-277 order
       Region 4blb A 278-278 disorder
       Region 4blb A 361-361 disorder
       Region 4blb A 362-449 order
       Region 4blb A 450-452 disorder
       Region 4blb A 453-453 order
       Region 4blb A 457-478 order
       Region 4blb A 479-483 disorder
 Evidence X-RAY 4blb B Reference
       Region 4blb B 32-276 order
       Region 4blb B 277-278 disorder
       Region 4blb B 361-367 disorder
       Region 4blb B 368-408 order
       Region 4blb B 409-410 disorder
       Region 4blb B 411-422 order
       Region 4blb B 423-425 disorder
       Region 4blb B 426-449 order
       Region 4blb B 450-453 disorder
       Region 4blb B 457-477 order
       Region 4blb B 478-483 disorder
 Evidence X-RAY 4blb C Reference
       Region 4blb C 32-278 order
       Region 4blb C 361-446 order
       Region 4blb C 447-453 disorder
       Region 4blb C 457-473 order
       Region 4blb C 474-483 disorder
 Evidence X-RAY 4blb D Reference
       Region 4blb D 32-276 order
       Region 4blb D 277-278 disorder
       Region 4blb D 361-450 order
       Region 4blb D 451-453 disorder
       Region 4blb D 457-478 order
       Region 4blb D 479-483 disorder
Seq 32-278,361-483 Hetero trimer : IID90020Complex
 Evidence X-RAY 4bla B Reference
       Region 4bla B 32-278 order
       Region 4bla B 361-448 order
       Region 4bla B 449-457 disorder
       Region 4bla B 458-481 order
       Region 4bla B 482-483 disorder
Seq 32-278,361-453,457-483 Hetero hexadecamer : IID00925Complex,IID90020Complex
 Evidence X-RAY 4bld A Reference
       Region 4bld A 32-277 order
       Region 4bld A 278-278 disorder
       Region 4bld A 361-361 disorder
       Region 4bld A 362-449 order
       Region 4bld A 450-452 disorder
       Region 4bld A 453-453 order
       Region 4bld A 457-478 order
       Region 4bld A 479-483 disorder
 Evidence X-RAY 4bld B Reference
       Region 4bld B 32-276 order
       Region 4bld B 277-278 disorder
       Region 4bld B 361-367 disorder
       Region 4bld B 368-408 order
       Region 4bld B 409-410 disorder
       Region 4bld B 411-422 order
       Region 4bld B 423-425 disorder
       Region 4bld B 426-449 order
       Region 4bld B 450-453 disorder
       Region 4bld B 457-477 order
       Region 4bld B 478-483 disorder
 Evidence X-RAY 4bld C Reference
       Region 4bld C 32-278 order
       Region 4bld C 361-446 order
       Region 4bld C 447-453 disorder
       Region 4bld C 457-473 order
       Region 4bld C 474-483 disorder
 Evidence X-RAY 4bld D Reference
       Region 4bld D 32-276 order
       Region 4bld D 277-278 disorder
       Region 4bld D 361-450 order
       Region 4bld D 451-453 disorder
       Region 4bld D 457-478 order
       Region 4bld D 479-483 disorder
Seq 32-278,361-483 Hetero dodecamer : IID90020Complex
 Evidence X-RAY 4bl9 A Reference
       Region 4bl9 A 32-275 order
       Region 4bl9 A 276-278 disorder
       Region 4bl9 A 361-448 order
       Region 4bl9 A 449-456 disorder
       Region 4bl9 A 457-477 order
       Region 4bl9 A 478-483 disorder
 Evidence X-RAY 4bl9 B Reference
       Region 4bl9 B 32-278 order
       Region 4bl9 B 361-450 order
       Region 4bl9 B 451-457 disorder
       Region 4bl9 B 458-481 order
       Region 4bl9 B 482-483 disorder
 Evidence X-RAY 4bl9 C Reference
       Region 4bl9 C 32-277 order
       Region 4bl9 C 278-278 disorder
       Region 4bl9 C 361-448 order
       Region 4bl9 C 449-456 disorder
       Region 4bl9 C 457-477 order
       Region 4bl9 C 478-483 disorder
 Evidence X-RAY 4bl9 D Reference
       Region 4bl9 D 32-278 order
       Region 4bl9 D 361-449 order
       Region 4bl9 D 450-457 disorder
       Region 4bl9 D 458-481 order
       Region 4bl9 D 482-483 disorder
Seq 32-278,361-483 Hetero trimer : IID90020Complex
 Evidence X-RAY 4bla D Reference
       Region 4bla D 32-278 order
       Region 4bla D 361-452 order
       Region 4bla D 453-456 disorder
       Region 4bla D 457-481 order
       Region 4bla D 482-483 disorder
Seq 32-278,361-483 Hetero trimer : IID90020Complex
 Evidence X-RAY 4bla C Reference
       Region 4bla C 32-277 order
       Region 4bla C 278-278 disorder
       Region 4bla C 361-447 order
       Region 4bla C 448-457 disorder
       Region 4bla C 458-481 order
       Region 4bla C 482-483 disorder
Seqphosphorylation
    352-352 Phosphoserine
    481-481 Phosphoserine
    353-353 Phosphothreonine
    346-346 Phosphoserine
    342-342 Phosphoserine
    301-301 Phosphoserine
Seqacetylation
    303-303 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-27,290-358
Order 28-79,84-289,359-484
ProS 290-325,333-345
AlphaFold
Disorder 1-28,280-300,315-361,453-455,481-484
Order 29-279,301-314,362-452,456-480
SEG 8-25 ,385-394
Function
Function in SwissProt
Negative regulator in the hedgehog/smoothened signaling pathway (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:12068298, PubMed:12975309, PubMed:27234298, PubMed:15367681, PubMed:22365972, PubMed:24217340, PubMed:24311597, PubMed:28965847). Down-regulates GLI1-mediated transactivation of target genes (PubMed:15367681, PubMed:24217340, PubMed:24311597). Down-regulates GLI2-mediated transactivation of target genes (PubMed:24311597, PubMed:24217340). Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:24217340). Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein (PubMed:10559945, PubMed:10564661, PubMed:10806483, PubMed:24217340). Negative regulator of beta-catenin signaling (By similarity). Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL) (PubMed:24311597, PubMed:28965847). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state (PubMed:24311597, PubMed:28965847). Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R (PubMed:24311597, PubMed:28965847). When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A) (PubMed:24311597, PubMed:28965847). Required for normal embryonic development (By similarity). Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity).
Biological Process
See also
Diagram with PDB data
GLI1/SUFUCrystal structure of Sufud60-Gli1p