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IID01031
 UniprotQ9Y2R2
ProteinTyrosine-protein phosphatase non-receptor type 22
GenePTPN22
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
807
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-294 Hetero dimer : O75563
 Evidence X-RAY 3omh A Reference
       Region 3omh A 1-294 order
 Evidence X-RAY 3omh B Reference
       Region 3omh B 1-195 order
       Region 3omh B 196-198 disorder
       Region 3omh B 199-294 order
 Evidence X-RAY 3omh C Reference
       Region 3omh C 1-294 order
 Evidence X-RAY 3omh D Reference
       Region 3omh D 1-294 order
Seq 1-294 Hetero dimer :
 Evidence X-RAY 3olr D Reference
       Region 3olr D 1-294 order
Seq 1-294 Hetero dimer :
 Evidence X-RAY 3olr C Reference
       Region 3olr C 1-294 order
Seq 1-294 Hetero dimer :
 Evidence X-RAY 3olr A Reference
       Region 3olr A 1-294 order
Seq 1-294 Hetero dimer :
 Evidence X-RAY 3olr B Reference
       Region 3olr B 1-294 order
Seq 1-303 Monomer :
 Evidence X-RAY 2p6x A Reference
       Region 2p6x A 1-77 order
       Region 2p6x A 78-78 disorder
       Region 2p6x A 79-302 order
 Evidence X-RAY 2p6x B Reference
       Region 2p6x B 1-2 disorder
       Region 2p6x B 3-298 order
       Region 2p6x B 299-302 disorder
 Evidence X-RAY 2qcj A Reference
       Region 2qcj A 1-6 disorder
       Region 2qcj A 7-215 order
       Region 2qcj A 216-219 disorder
       Region 2qcj A 220-290 order
       Region 2qcj A 291-294 disorder
 Evidence X-RAY 2qcj B Reference
       Region 2qcj B 1-6 disorder
       Region 2qcj B 7-215 order
       Region 2qcj B 216-219 disorder
       Region 2qcj B 220-290 order
       Region 2qcj B 291-294 disorder
 Evidence X-RAY 2qct A Reference
       Region 2qct A 1-2 disorder
       Region 2qct A 3-12 order
       Region 2qct A 13-22 disorder
       Region 2qct A 23-294 order
 Evidence X-RAY 2qct B Reference
       Region 2qct B 1-1 disorder
       Region 2qct B 2-17 order
       Region 2qct B 18-20 disorder
       Region 2qct B 21-34 order
       Region 2qct B 35-39 disorder
       Region 2qct B 40-294 order
 Evidence X-RAY 3h2x A Reference
       Region 3h2x A 1-302 order
 Evidence X-RAY 4j51 A Reference
       Region 4j51 A 1-77 order
       Region 4j51 A 78-78 disorder
       Region 4j51 A 79-303 order
 Evidence X-RAY 4j51 B Reference
       Region 4j51 B 1-77 order
       Region 4j51 B 78-78 disorder
       Region 4j51 B 79-303 order
Seq 1-310 Hetero dimer : IID00770Complex
 Evidence X-RAY 3brh A Reference
       Region 3brh A 1-2 disorder
       Region 3brh A 3-298 order
       Region 3brh A 299-310 disorder
 Evidence X-RAY 3brh B Reference
       Region 3brh B 1-76 order
       Region 3brh B 77-80 disorder
       Region 3brh B 81-300 order
       Region 3brh B 301-310 disorder
Seq 787-807 Hetero trimer : O43586
 Evidence X-RAY 7aam C Reference
       Region 7aam C 787-792 disorder
       Region 7aam C 793-806 order
       Region 7aam C 807-807 disorder
SeqProS predicted 793-806 This region is predicted to be disordered by AlphaFold and NeProc. Hetero trimer : O43586
       Region 7aam C 793-806 order
Seqphosphorylation
    35-35 Phosphoserine; by PKC/PRKCD
    449-449 Phosphoserine
    635-635 Phosphoserine
    684-684 Phosphoserine
    692-692 Phosphoserine
 
Prediction
NeProc
Disorder 303-807
Order 1-297
ProS 303-313,323-325,333-335,353-391,401-418,427-472,477-483,498-502,508-525,530-534,550-566,585-589,605-612,618-634,648-660,671-688,705-709,740-759,784-807
AlphaFold
Disorder 195-197,303-799,806-807
Order 1-194,198-302,800-805
SEG 562-576 ,777-790
Function
Function in SwissProt
Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3 (PubMed:27043286). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity).
Biological Process
See also
Diagram with PDB data
LCKSH3-SH2 DOMAIN FRAGMENT OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 10 RESIDUE SYNTHETIC PHOSPHOTYROSYL PEPTIDE TEGQPYQPQPA