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IID01033
 UniprotQ9Y376
ProteinCalcium-binding protein 39
GeneCAB39
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
341
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-341 Hetero trimer : IID00217Complex,IID00613Complex
 Evidence X-RAY 2wtk D Reference
       Region 2wtk D 1-9 disorder
       Region 2wtk D 10-58 order
       Region 2wtk D 59-59 disorder
       Region 2wtk D 60-313 order
       Region 2wtk D 314-314 disorder
       Region 2wtk D 315-336 order
       Region 2wtk D 337-341 disorder
 Evidence X-RAY 2wtk A Reference
       Region 2wtk A 1-8 disorder
       Region 2wtk A 9-29 order
       Region 2wtk A 30-30 disorder
       Region 2wtk A 31-55 order
       Region 2wtk A 56-57 disorder
       Region 2wtk A 58-313 order
       Region 2wtk A 314-317 disorder
       Region 2wtk A 318-336 order
       Region 2wtk A 337-341 disorder
Seq 1-341 Hetero dimer : IID00217Complex
 Evidence X-RAY 3gni A Reference
       Region 3gni A 1-1 disorder
       Region 3gni A 2-336 order
       Region 3gni A 337-341 disorder
Seq 1-341 Hetero dimer : IID00217Complex
 Evidence X-RAY 1upk A Reference
       Region 1upk A 1-9 disorder
       Region 1upk A 10-28 order
       Region 1upk A 29-31 disorder
       Region 1upk A 32-55 order
       Region 1upk A 56-62 disorder
       Region 1upk A 63-313 order
       Region 1upk A 314-314 disorder
       Region 1upk A 315-338 order
       Region 1upk A 339-341 disorder
Seq 1-341 Monomer :
 Evidence X-RAY 1upl A Reference
       Region 1upl A 1-12 disorder
       Region 1upl A 13-29 order
       Region 1upl A 30-34 disorder
       Region 1upl A 35-58 order
       Region 1upl A 59-63 disorder
       Region 1upl A 64-333 order
       Region 1upl A 334-341 disorder
 Evidence X-RAY 1upl B Reference
       Region 1upl B 1-10 disorder
       Region 1upl B 11-27 order
       Region 1upl B 28-39 disorder
       Region 1upl B 40-55 order
       Region 1upl B 56-59 disorder
       Region 1upl B 60-333 order
       Region 1upl B 334-341 disorder
Seq 8-334 Hetero dimer : O00506
 Evidence X-RAY 4nzw A Reference
       Region 4nzw A 8-10 disorder
       Region 4nzw A 11-27 order
       Region 4nzw A 28-33 disorder
       Region 4nzw A 34-56 order
       Region 4nzw A 57-59 disorder
       Region 4nzw A 60-314 order
       Region 4nzw A 315-318 disorder
       Region 4nzw A 319-332 order
       Region 4nzw A 333-334 disorder
Seq 11-333 Hetero trimer : Q9Y6E0
 Evidence X-RAY 4o27 A Reference
       Region 4o27 A 11-333 order
Seq 11-334 Hetero dimer : IID01027Complex
 Evidence X-RAY 4fza A Reference
       Region 4fza A 11-56 order
       Region 4fza A 57-57 disorder
       Region 4fza A 58-334 order
 Evidence X-RAY 4fzf A Reference
       Region 4fzf A 11-334 order
Seq 11-334 Hetero trimer : IID01027Complex
 Evidence X-RAY 4fzd A Reference
       Region 4fzd A 11-29 order
       Region 4fzd A 30-31 disorder
       Region 4fzd A 32-333 order
       Region 4fzd A 334-334 disorder
SeqProS verified 2-10 Hetero dimer : IID00217Complex
       Region 3gni A 2-336 order
       Region 1upl B 1-10 disorder
 
Prediction
NeProc
Disorder 1-11,335-341
Order 12-334
AlphaFold
Disorder 1-9,338-341
Order 10-337
Function
Function in SwissProt
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
Biological Process
See also
Diagram with PDB data
PRKAA2/PRKAB1/PRKAG1Structure of full length human AMPK in complex with a small molecule activator, a benzimidazole derivative (991)
STK11/CAB39/STRADAStructure of the heterotrimeric LKB1-STRADalpha-MO25alpha complex
STK26/CAB39Crystal structure of MST4-MO25 complex with WSF motif