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IID01035
 UniprotQ9Y4K1
ProteinBeta/gamma crystallin domain-containing protein 1
GeneCRYBG1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1723
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 716-741 Hetero dimer : IID00975Complex
 Evidence X-RAY 6vro B Reference
       Region 6vro B 716-727 disorder
       Region 6vro B 728-741 order
Seq 1022-1117 Monomer :
 Evidence X-RAY 3cw3 A Reference
       Region 3cw3 A 1022-1030 order
       Region 3cw3 A 1031-1033 disorder
       Region 3cw3 A 1034-1117 order
Seq 1416-1495 Monomer :
 Evidence NMR 2dad A Reference
       Region 2dad A 1416-1495 order
SeqProS predicted 728-741 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00975Complex
       Region 6vro B 728-741 order
Seqphosphorylation
    525-525 Phosphothreonine
    484-484 Phosphoserine
    348-348 Phosphoserine
    329-329 Phosphoserine
    81-81 Phosphoserine
    75-75 Phosphoserine
 
Prediction
NeProc
Disorder 1-1009,1098-1104,1409-1412
Order 1010-1097,1105-1247,1257-1408,1413-1723
ProS 185-196,212-221,238-243,272-277,303-312,551-554,698-705,711-715,730-753,788-791,819-838,921-925,965-968,975-998,1004-1009,1409-1412
AlphaFold
Disorder 1-702,704-1014,1030-1035,1088-1089,1091-1105,1149-1151,1244-1260,1407-1414,1722-1723
Order 703-703,1015-1029,1036-1087,1090-1090,1106-1148,1152-1243,1261-1406,1415-1721
Pfam Hmmer
1219->1312 1124-1205 1320->1403
SEG 4-16 ,71-82 ,116-129 ,200-213 ,456-474 ,683-696 ,829-842 ,863-880 ,908-920 ,1079-1089 ,1245-1254
Function
Function in SwissProt
May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton.