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IID01037
 UniprotQ9Y624
ProteinJunctional adhesion molecule A
GeneF11R
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
299
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 27-233 Homo dimer :
 Evidence X-RAY 1nbq A Reference
       Region 1nbq A 27-233 order
 Evidence X-RAY 1nbq B Reference
       Region 1nbq B 27-233 order
Seq 28-129 Hetero hexamer : P03528
 Evidence X-RAY 3eoy G Reference
       Region 3eoy G 28-129 order
 Evidence X-RAY 3eoy H Reference
       Region 3eoy H 28-129 order
 Evidence X-RAY 3eoy I Reference
       Region 3eoy I 28-129 order
 Evidence X-RAY 3eoy J Reference
       Region 3eoy J 28-129 order
 Evidence X-RAY 3eoy K Reference
       Region 3eoy K 28-129 order
 Evidence X-RAY 3eoy L Reference
       Region 3eoy L 28-129 order
Seq 28-129 Hetero hexamer : P04506
 Evidence X-RAY 4odb D Reference
       Region 4odb D 28-129 order
 Evidence X-RAY 4odb E Reference
       Region 4odb E 28-129 order
 Evidence X-RAY 4odb F Reference
       Region 4odb F 28-129 order
Seq 288-299 Hetero dimer : Q07157
 Evidence X-RAY 3tsz B Reference
       Region 3tsz B 288-289 disorder
       Region 3tsz B 290-299 order
SeqProS predicted 290-299 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc; PDZ binding motif (Class II) Hetero dimer : Q07157
       Region 3tsz B 290-299 order
Seqphosphorylation
    287-287 Phosphoserine
    284-284 Phosphoserine
    281-281 Phosphoserine
 
Prediction
NeProc
Disorder 1-11,182-186,262-299
Order 12-175,187-261
ProS 11-11,262-268,276-281,287-299
AlphaFold
Disorder 1-6,8-11,18-27,264-299
Order 7-7,12-17,28-263
SEG 11-26 ,236-254
Function
Function in SwissProt
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840).
(Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.
(Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.