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IID01038
 UniprotQ9Y698
ProteinVoltage-dependent calcium channel gamma-2 subunit
GeneCACNG2
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
323
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 225-232 Hetero hexamer : A0A2I2UQ80
 Evidence X-RAY 6tno B Reference
       Region 6tno B 225-225 disorder
       Region 6tno B 226-232 order
 Evidence X-RAY 6tno D Reference
       Region 6tno D 225-225 disorder
       Region 6tno D 226-232 order
 Evidence X-RAY 6tno F Reference
       Region 6tno F 225-232 order
SeqProS predicted 225-232 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero hexamer : A0A2I2UQ80
       Region 6tno B 226-232 order
       Region 6tno D 226-232 order
       Region 6tno F 225-232 order
Seqphosphorylation
    253-253 Phosphoserine
    271-271 Phosphotyrosine
    321-321 Phosphothreonine
 
Prediction
NeProc
Disorder 1-6,84-92,102-105,129-134,207-290
Order 7-83,93-101,106-128,135-206,291-323
ProS 1-6,84-92,102-105,129-134,207-231,238-255,266-277,286-290
AlphaFold
Disorder 1-4,38-57,80-92,96-96,99-101,103-104,130-130,161-173,217-323
Order 5-37,58-79,93-95,97-98,102-102,105-129,131-160,174-216
SEG 165-176 ,228-243
Function
Function in SwissProt
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.