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IID01039
 UniprotQ9Y6B2
ProteinEP300-interacting inhibitor of differentiation 1
GeneEID1
OrganismHomo sapiens
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
187
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 174-187 Hetero dimer : IID00130Complex
 Evidence X-RAY 7smd B Reference
       Region 7smd B 174-187 order
SeqProS predicted 181-187 LXCXE motif; this region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero dimer : IID00130Complex
       Region 7smd B 174-187 order
 
Prediction
NeProc
Disorder 1-106,181-187
Order 107-180
ProS 7-29,73-106,181-187
AlphaFold
Disorder 1-125,135-135,138-158,179-187
Order 126-134,136-137,159-178
SEG 1-15 ,49-71 ,92-115
Function
Function in SwissProt
Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms.