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IID50040
 UniprotP17679
ProteinErythroid transcription factor
GeneGata1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
413
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 200-238 Hetero trimer : IID50043Complex,IID50049Complex
 Evidence NMR 2l6y A Reference
       Region 2l6y A 200-238 order
Seq 200-238 Hetero tetramer : IID50043Complex,IID50049Complex,IID50106Complex
 Evidence NMR 2l6z A Reference
       Region 2l6z A 200-238 order
Seq 200-243 Hetero dimer : IID50106Complex
 Evidence NMR 1y0j A Reference
       Region 1y0j A 200-238 order
       Region 1y0j A 239-243 disorder
Seq 200-243 Monomer :
 Evidence NMR 1gnf A Reference
       Region 1gnf A 200-243 order
       Region 1gnf A 242-243 high_rmsd
Seq 200-318 Monomer :
 Evidence X-RAY 3vd6 C Reference
       Region 3vd6 C 200-200 disorder
       Region 3vd6 C 201-241 order
       Region 3vd6 C 242-255 disorder
       Region 3vd6 C 256-310 order
       Region 3vd6 C 311-318 disorder
 Evidence X-RAY 3vek C Reference
       Region 3vek C 200-200 disorder
       Region 3vek C 201-241 order
       Region 3vek C 242-255 disorder
       Region 3vek C 256-310 order
       Region 3vek C 311-318 disorder
 Evidence X-RAY 3vek F Reference
       Region 3vek F 200-200 disorder
       Region 3vek F 201-241 order
       Region 3vek F 242-255 disorder
       Region 3vek F 256-310 order
       Region 3vek F 311-318 disorder
Seq 308-320 Hetero dimer : IID50153Complex
 Evidence NMR 2l5e B Reference
       Region 2l5e B 308-310 disorder
       Region 2l5e B 311-316 order
       Region 2l5e B 317-320 disorder
Seqphosphorylation
    310-310 Phosphoserine
    187-187 Phosphoserine
    178-178 Phosphoserine
    142-142 Phosphoserine
    72-72 Phosphoserine
    49-49 Phosphoserine
    26-26 Phosphoserine
    26-26 Phosphoserine
    49-49 Phosphoserine
    72-72 Phosphoserine
    142-142 Phosphoserine
    178-178 Phosphoserine
    187-187 Phosphoserine
    310-310 Phosphoserine
Seqacetylation
    315-315 N6-acetyllysine
    314-314 N6-acetyllysine
    312-312 N6-acetyllysine; by CREBBP
    308-308 N6-acetyllysine
    252-252 N6-acetyllysine; by CREBBP
    246-246 N6-acetyllysine; by EP300
    246-246 N6-acetyllysine; by CREBBP
    245-245 N6-acetyllysine; by EP300
    233-233 N6-acetyllysine; by EP300
    233-233 N6-acetyllysine; by EP300
    245-245 N6-acetyllysine; by EP300
    246-246 N6-acetyllysine; by CREBBP
    246-246 N6-acetyllysine; by EP300
    252-252 N6-acetyllysine; by CREBBP
    308-308 N6-acetyllysine
    312-312 N6-acetyllysine; by CREBBP
    314-314 N6-acetyllysine
    315-315 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-226,234-251,297-413
Order 227-233,252-296
ProS 1-23,31-36,124-130,140-147,156-173,203-226,234-242,297-305,380-385
AlphaFold
Disorder 1-200,246-252,309-409,411-413
Order 201-245,253-308,410-410
Pfam Hmmer
PF00320 204-238 9.2e-18
PF00320 258-292 5.3e-19
SEG 25-38 ,43-68 ,168-182 ,256-267 ,305-320 ,322-333 ,352-361 ,389-406
Function
Function in SwissProt
Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS.
Biological Process
See also
Diagram with PDB data
Ldb1/Lmo2/Gata1haddock model of GATA1NF:Lmo2LIM2-Ldb1LID