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IID50049
 UniprotP70662
ProteinLIM domain-binding protein 1
GeneLdb1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
411
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 331-375 Hetero dimer : IID50046Complex
 Evidence NMR 2jtn A Reference
       Region 2jtn A 331-335 disorder
       Region 2jtn A 331-375 order
       Region 2jtn A 331-335 high_rmsd
       Region 2jtn A 336-369 order
       Region 2jtn A 370-375 disorder
       Region 2jtn A 370-375 high_rmsd
Seq 336-348 Hetero trimer : IID50040Complex,IID50043Complex
 Evidence NMR 2l6y B Reference
       Region 2l6y B 336-348 order
Seq 336-348 Hetero tetramer : IID50040Complex,IID50043Complex
 Evidence NMR 2l6z C Reference
       Region 2l6z C 336-348 order
Seq 336-366 Hetero dimer : IID50047Complex
 Evidence X-RAY 4jcj A Reference
       Region 4jcj A 336-346 order
       Region 4jcj A 347-351 disorder
       Region 4jcj A 352-363 order
       Region 4jcj A 364-366 disorder
Seq 336-366 Hetero dimer : IID50047Complex
 Evidence X-RAY 4jcj B Reference
       Region 4jcj B 336-336 disorder
       Region 4jcj B 337-346 order
       Region 4jcj B 347-350 disorder
       Region 4jcj B 351-364 order
       Region 4jcj B 365-366 disorder
Seq 336-366 Hetero dimer : IID50047Complex
 Evidence X-RAY 4jcj C Reference
       Region 4jcj C 336-347 order
       Region 4jcj C 348-350 disorder
       Region 4jcj C 351-364 order
       Region 4jcj C 365-366 disorder
Seqdisorder 336-374
 Evidence CD Reference
       Region 336-374 disorder
Seq 336-375 Hetero dimer : IID50048Complex
 Evidence X-RAY 1rut X Reference
       Region 1rut X 336-363 order
       Region 1rut X 364-375 disorder
Seq 336-375 Hetero dimer : IID50043Complex
 Evidence NMR 1j2o A Reference
       Region 1j2o A 336-356 disorder
       Region 1j2o A 336-375 order
       Region 1j2o A 336-356 high_rmsd
       Region 1j2o A 357-363 order
       Region 1j2o A 364-375 disorder
       Region 1j2o A 364-375 high_rmsd
Seq 336-375 Hetero dimer : IID50043Complex
 Evidence NMR 2lxd A Reference
       Region 2lxd A 336-345 order
       Region 2lxd A 345-375 high_rmsd
       Region 2lxd A 346-375 disorder
Seq 336-375 Hetero dimer : IID50048Complex
 Evidence NMR 1m3v A Reference
       Region 1m3v A 336-353 disorder
       Region 1m3v A 336-375 order
       Region 1m3v A 336-353 high_rmsd
       Region 1m3v A 354-363 order
       Region 1m3v A 364-375 disorder
       Region 1m3v A 364-375 high_rmsd
SeqProS verified 336-348 Hetero tetramer : IID50040Complex,IID50043Complex
       Region 2l6z C 336-348 order
       Region 336-374 disorder
SeqProS verified 336-348 Hetero trimer : IID50040Complex,IID50043Complex
       Region 2l6y B 336-348 order
       Region 336-374 disorder
SeqProS verified 336-363 Hetero dimer : IID50048Complex
       Region 1rut X 336-363 order
       Region 336-374 disorder
SeqProS verified 336-347,351-364 Hetero dimer : IID50047Complex
       Region 4jcj A 336-346 order
       Region 4jcj A 352-363 order
       Region 336-374 disorder
SeqProS verified 336-347,351-364 Hetero dimer : IID50047Complex
       Region 4jcj C 336-347 order
       Region 4jcj C 351-364 order
       Region 336-374 disorder
SeqProS verified 336-347,351-364 Hetero dimer : IID50047Complex
       Region 4jcj B 337-346 order
       Region 4jcj B 351-364 order
       Region 336-374 disorder
SeqProS verified 336-369 Hetero dimer : IID50046Complex
       Region 2jtn A 336-369 order
       Region 336-374 disorder
SeqProS verified 337-345 Hetero dimer : IID50043Complex
       Region 2lxd A 336-345 order
       Region 336-374 disorder
SeqProS verified 354-363 Hetero dimer : IID50048Complex
       Region 1m3v A 354-363 order
       Region 336-374 disorder
SeqProS verified 357-363 Hetero dimer : IID50043Complex
       Region 1j2o A 357-363 order
       Region 336-374 disorder
Seqphosphorylation
    302-302 Phosphoserine
    265-265 Phosphoserine
    61-61 Phosphothreonine
    61-61 Phosphothreonine
    265-265 Phosphoserine
    302-302 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-62,222-236,269-411
Order 63-215,237-268
ProS 1-7,228-236,269-282
AlphaFold
Disorder 1-64,285-411
Order 65-284
Pfam Hmmer
PF01803 37-411 9.1e-299
SEG 300-323 ,391-404
Function
Function in SwissProt
Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state.
Biological Process
Diagram with PDB data
Ldb1/Lmo2/Gata1haddock model of GATA1NF:Lmo2LIM2-Ldb1LID