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IID50306
 UniprotO88513
ProteinGeminin
GeneGmnn
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
206
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 79-157 Hetero trimer : IID50342Complex
 Evidence X-RAY 2zxx A Reference
       Region 2zxx A 79-87 disorder
       Region 2zxx A 88-157 order
 Evidence X-RAY 2zxx B Reference
       Region 2zxx B 79-156 order
       Region 2zxx B 157-157 disorder
 Evidence X-RAY 2zxx D Reference
       Region 2zxx D 79-92 disorder
       Region 2zxx D 93-157 order
 Evidence X-RAY 2zxx E Reference
       Region 2zxx E 79-156 order
       Region 2zxx E 157-157 disorder
SeqProS verified 79-87 Hetero trimer : IID50342Complex
       Region 2zxx B 79-156 order
       Region 2zxx E 79-156 order
       Region 2zxx A 79-87 disorder
Seqphosphorylation
    36-36 Phosphoserine
    63-63 Phosphoserine
    64-64 Phosphoserine
    181-181 Phosphoserine; by CK2
Seqacetylation
    27-27 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-87,159-206
Order 93-158
ProS 14-42,52-56,74-87,159-165,186-192,201-206
AlphaFold
Disorder 1-4,7-20,34-78,158-206
Order 5-6,21-33,79-157
Pfam Hmmer
PF07412 1-187 4.4e-130
SEG 170-186
Function
Function in SwissProt
Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.
Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control.