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IID50388
 UniprotQ0VBL6
ProteinHypoxia-inducible factor 3-alpha
GeneHif3a
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
662
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 4-358 Hetero dimer : IID50373Complex
 Evidence X-RAY 7v7l B Reference
       Region 7v7l B 4-18 disorder
       Region 7v7l B 19-73 order
       Region 7v7l B 74-79 disorder
       Region 7v7l B 80-144 order
       Region 7v7l B 145-153 disorder
       Region 7v7l B 154-195 order
       Region 7v7l B 196-213 disorder
       Region 7v7l B 214-227 order
       Region 7v7l B 228-229 disorder
       Region 7v7l B 230-322 order
       Region 7v7l B 323-328 disorder
       Region 7v7l B 329-358 order
 Evidence X-RAY 7v7w B Reference
       Region 7v7w B 4-18 disorder
       Region 7v7w B 19-73 order
       Region 7v7w B 74-81 disorder
       Region 7v7w B 82-144 order
       Region 7v7w B 145-153 disorder
       Region 7v7w B 154-196 order
       Region 7v7w B 197-214 disorder
       Region 7v7w B 215-227 order
       Region 7v7w B 228-237 disorder
       Region 7v7w B 238-322 order
       Region 7v7w B 323-328 disorder
       Region 7v7w B 329-357 order
       Region 7v7w B 358-358 disorder
 
Prediction
NeProc
Disorder 1-24,140-155,174-185,198-212,347-662
Order 25-139,156-173,186-197,213-346
ProS 12-24,140-147,155-155,174-185,205-209,347-354,371-376,386-390,401-411,416-421,441-450,455-462,477-503,520-527,535-541,559-566,571-587,595-611,620-644,650-662
AlphaFold
Disorder 1-7,72-82,146-156,198-211,231-233,323-328,355-382,389-394,398-398,420-662
Order 8-71,83-145,157-197,212-230,234-322,329-354,383-388,395-397,399-419
Pfam Hmmer
PF08447 249-342 1.2e-18
SEG 421-437 ,508-520 ,525-536 ,595-607
Function
Function in SwissProt
Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:9840812, PubMed:11734856, PubMed:21546903). Plays a role in the development of the cardiorespiratory system (PubMed:18070924).
Acts as a positive regulator of hypoxia-inducible gene expression. Associates to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters in a ARNT-dependent manner, and hence also participates in the transcriptional activation of reporter genes driven by HRE (PubMed:9840812).
Attenuates the ability of transcription factor HIF1A, EPAS1 and the HIF1A-ARNT complex to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. May act as a tumor suppressor (PubMed:11734856). May also be involved in apoptosis (PubMed:21546903).
Attenuates the ability of transcription factor HIF1A, EPAS1 and the HIF1A-ARNT complex to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation (PubMed:18070924). Also plays a role in the development of the lung and heart during embryonic and neonatal stages (PubMed:18070924).