Structure
Experiment
671
order/disorder by at least rule
disorder by at least rule
order by at least rule
order/disorder by majority rule
Seq 362-669 Monomer :
Region 5v3j E 362-638 order
Region 5v3j E 639-640 disorder
Region 5v3j F 362-639 order
Region 5v3j F 640-640 disorder
Region 5v3m C 362-638 order
Region 5v3m C 639-669 disorder
Region 5wjq D 388-666 order
Region 5wjq D 667-668 disorder
Prediction
NeProc
Disorder 1-30,97-122,183-188,208-222,667-671
Order 31-96,123-182,189-207,223-666
ProS 1-16,97-122,183-188,208-222,667-671
AlphaFold
Disorder 1-33,94-123,182-361,366-370,382-389,392-392,399-399,401-401,408-408,412-418,468-468,471-474,668-671
Order 34-93,124-181,362-365,371-381,390-391,393-398,400-400,402-407,409-411,419-467,469-470,475-667
Function
Function in SwissProt
Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction (PubMed:22110054, PubMed:27658112). Essential during embryonic development, where it acts as direct repressor of IGF2-P0, placental-specific transcript of IGF2, in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers (PubMed:18701545, PubMed:22110054, PubMed:28522536). Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta (PubMed:18701545, PubMed:21094155). May enhance proliferation or maintenance of neural stem cells (PubMed:23071813).
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