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IID50414
 UniprotO35430
ProteinAmyloid-beta A4 precursor protein-binding family A member 1
GeneApba1
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
839
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 227-303 Hetero trimer : P61765
 Evidence X-RAY 7xsj C Reference
       Region 7xsj C 227-265 disorder
       Region 7xsj C 266-283 order
       Region 7xsj C 284-303 disorder
Seq 338-397 Hetero tetramer : O14936
 Evidence X-RAY 6kmh C Reference
       Region 6kmh C 338-385 order
       Region 6kmh C 386-397 disorder
 Evidence X-RAY 6kmh D Reference
       Region 6kmh D 338-387 order
       Region 6kmh D 388-397 disorder
Seq 453-496,509-568,586-643 Monomer :
 Evidence X-RAY 4dbb A Reference
       Region 4dbb A 453-454 disorder
       Region 4dbb A 455-496 order
       Region 4dbb A 509-513 disorder
       Region 4dbb A 514-568 order
       Region 4dbb A 586-620 order
       Region 4dbb A 621-622 disorder
       Region 4dbb A 623-640 order
       Region 4dbb A 641-643 disorder
SeqProS predicted 266-283 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero trimer : P61765
       Region 7xsj C 266-283 order
Seqphosphorylation
    79-79 Phosphoserine
    243-243 Phosphoserine
    247-247 Phosphoserine
    249-249 Phosphoserine
    264-264 Phosphoserine
    281-281 Phosphoserine
    286-286 Phosphoserine
    306-306 Phosphothreonine
    314-314 Phosphoserine
    372-372 Phosphothreonine
    369-369 Phosphoserine
    403-403 Phosphoserine
    405-405 Phosphoserine
    410-410 Phosphoserine
    570-570 Phosphoserine
 
Prediction
NeProc
Disorder 1-450,477-516,563-598,604-612
Order 451-476,517-562,599-603,613-628,632-637,643-839
ProS 6-35,69-75,84-100,106-110,116-133,151-155,162-171,178-219,229-252,270-278,315-324,344-348,379-382,390-407,443-450,486-498,589-598,604-612
AlphaFold
Disorder 1-340,362-450,476-478,504-515,563-587,622-653,678-679,681-681,776-776
Order 341-361,451-475,479-503,516-562,588-621,654-677,680-680,682-775,777-839
Pfam Hmmer
658->742 463-620 749->822
SEG 30-71 ,126-146 ,401-417
Function
Function in SwissProt
Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.