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IID50418
 UniprotO70511
ProteinAnkyrin-3
GeneAnk3
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
2622
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 275-500 Hetero dimer : P97685
 Evidence X-RAY 7xce A Reference
       Region 7xce A 275-496 order
       Region 7xce A 497-500 disorder
Seq 975-1465 Hetero tetramer : Q62261
 Evidence X-RAY 6m3p C Reference
       Region 6m3p C 975-983 disorder
       Region 6m3p C 984-1154 order
       Region 6m3p C 1155-1160 disorder
       Region 6m3p C 1161-1177 order
       Region 6m3p C 1178-1181 disorder
       Region 6m3p C 1182-1200 order
       Region 6m3p C 1201-1203 disorder
       Region 6m3p C 1204-1234 order
       Region 6m3p C 1235-1248 disorder
       Region 6m3p C 1249-1328 order
       Region 6m3p C 1329-1334 disorder
       Region 6m3p C 1335-1385 order
       Region 6m3p C 1386-1388 disorder
       Region 6m3p C 1389-1407 order
       Region 6m3p C 1408-1411 disorder
       Region 6m3p C 1412-1426 order
       Region 6m3p C 1427-1428 disorder
       Region 6m3p C 1429-1447 order
       Region 6m3p C 1448-1465 disorder
 Evidence X-RAY 6m3p E Reference
       Region 6m3p E 975-983 disorder
       Region 6m3p E 984-1154 order
       Region 6m3p E 1155-1160 disorder
       Region 6m3p E 1161-1177 order
       Region 6m3p E 1178-1181 disorder
       Region 6m3p E 1182-1200 order
       Region 6m3p E 1201-1203 disorder
       Region 6m3p E 1204-1234 order
       Region 6m3p E 1235-1247 disorder
       Region 6m3p E 1248-1328 order
       Region 6m3p E 1329-1334 disorder
       Region 6m3p E 1335-1385 order
       Region 6m3p E 1386-1388 disorder
       Region 6m3p E 1389-1407 order
       Region 6m3p E 1408-1411 disorder
       Region 6m3p E 1412-1426 order
       Region 6m3p E 1427-1428 disorder
       Region 6m3p E 1429-1450 order
       Region 6m3p E 1451-1465 disorder
Seq 975-1465 Hetero dimer : E9PX29
 Evidence X-RAY 6m3r E Reference
       Region 6m3r E 975-991 disorder
       Region 6m3r E 992-1154 order
       Region 6m3r E 1155-1160 disorder
       Region 6m3r E 1161-1200 order
       Region 6m3r E 1201-1203 disorder
       Region 6m3r E 1204-1234 order
       Region 6m3r E 1235-1247 disorder
       Region 6m3r E 1248-1328 order
       Region 6m3r E 1329-1334 disorder
       Region 6m3r E 1335-1385 order
       Region 6m3r E 1386-1388 disorder
       Region 6m3r E 1389-1407 order
       Region 6m3r E 1408-1411 disorder
       Region 6m3r E 1412-1426 order
       Region 6m3r E 1427-1428 disorder
       Region 6m3r E 1429-1450 order
       Region 6m3r E 1451-1465 disorder
Seq 1985-2010 Hetero dimer : IID50463Complex
 Evidence X-RAY 5yip B Reference
       Region 5yip B 1985-2007 order
       Region 5yip B 2008-2010 disorder
Seq 1985-2010 Hetero dimer : IID50469Complex
 Evidence X-RAY 5yiq D Reference
       Region 5yiq D 1985-1985 disorder
       Region 5yiq D 1986-2001 order
       Region 5yiq D 2002-2010 disorder
Seq 1987-2010 Hetero dimer : IID50471Complex
 Evidence X-RAY 6a9x A Reference
       Region 6a9x A 1987-2004 order
       Region 6a9x A 2005-2010 disorder
SeqProS predicted 1985-2007 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID50463Complex
       Region 5yip B 1985-2007 order
SeqProS predicted 1986-2001 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID50469Complex
       Region 5yiq D 1986-2001 order
SeqProS predicted 1987-2004 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID50471Complex
       Region 6a9x A 1987-2004 order
 
Prediction
NeProc
Disorder 1-3,39-39,842-975,1236-1244,1450-1456,1465-1486,1506-1510,1517-2358,2364-2396,2402-2622
Order 4-38,40-841,976-1235,1245-1449,1457-1464,1487-1505,1511-1516,2359-2363,2397-2401
ProS 1-3,39-39,842-854,863-933,938-949,958-975,1236-1244,1465-1486,1506-1510,1517-1522,1534-1541,1548-1553,1561-1592,1606-1613,1631-1638,1648-1663,1713-1724,1739-1749,1759-1781,1800-1803,1814-1832,1840-1861,1875-1884,1889-1922,1932-1935,1941-1970,1986-2002,2012-2034,2141-2155,2204-2209,2256-2259,2265-2289,2297-2302,2318-2325,2337-2358,2364-2376,2387-2396,2402-2457,2468-2472,2563-2569,2604-2619
AlphaFold
Disorder 1-39,196-201,224-235,827-1013,1018-1039,1080-1080,1100-1109,1113-1128,1216-1218,1233-1248,1258-1260,1342-1355,1385-1389,1398-1400,1427-1435,1446-1952,1954-2335,2418-2622
Order 40-195,202-223,236-826,1014-1017,1040-1079,1081-1099,1110-1112,1129-1215,1219-1232,1249-1257,1261-1341,1356-1384,1390-1397,1401-1426,1436-1445,1953-1953,2336-2417
Pfam Hmmer
106->138 73-105 139->171
SEG 24-40 ,827-838 ,913-930 ,1001-1014 ,1515-1536 ,1745-1762 ,1805-1827 ,1877-1898 ,1970-1985 ,2468-2481
Function
Function in SwissProt
Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (By similarity). In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (By similarity). Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions (PubMed:21617128).