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IID50420
 UniprotO88602
ProteinVoltage-dependent calcium channel gamma-2 subunit
GeneCacng2
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
323
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 225-233 Hetero dimer : Q63053
 Evidence X-RAY 4x3h B Reference
       Region 4x3h B 225-233 order
Seq 318-323 Hetero dimer : Q62936
 Evidence X-RAY 3jxt D Reference
       Region 3jxt D 318-323 order
 Evidence X-RAY 3jxt C Reference
       Region 3jxt C 318-323 order
SeqProS predicted 225-233 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : Q63053
       Region 4x3h B 225-233 order
SeqProS predicted 318-323 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : Q62936
       Region 3jxt C 318-323 order
       Region 3jxt D 318-323 order
 
Prediction
NeProc
Disorder 1-6,72-77,84-105,129-134,207-291,314-323
Order 7-71,78-83,106-128,135-206,292-313
ProS 1-6,72-77,84-105,129-134,207-230,238-255,265-278,286-291,314-323
AlphaFold
Disorder 1-4,39-56,80-92,96-96,100-100,103-104,162-173,217-323
Order 5-38,57-79,93-95,97-99,101-102,105-161,174-216
SEG 165-176 ,228-243
Function
Function in SwissProt
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).