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IID50422
UniprotP02829
ProteinATP-dependent molecular chaperone HSP82
GeneHSP82
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
709
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-214 Homo tetramer :
 Evidence X-RAY 2vw5 A Reference
       Region 2vw5 A 1-214 order
 Evidence X-RAY 2vw5 B Reference
       Region 2vw5 B 1-214 order
 Evidence X-RAY 2vw5 C Reference
       Region 2vw5 C 1-214 order
 Evidence X-RAY 2vw5 D Reference
       Region 2vw5 D 1-214 order
Seq 1-214 Hetero dimer : Q16543
 Evidence X-RAY 1us7 A Reference
       Region 1us7 A 1-1 disorder
       Region 1us7 A 2-207 order
       Region 1us7 A 208-214 disorder
Seq 1-220 Monomer :
 Evidence X-RAY 2akp A Reference
       Region 2akp A 25-26 disorder
       Region 2akp A 27-210 order
 Evidence X-RAY 2akp B Reference
       Region 2akp B 25-28 disorder
       Region 2akp B 29-209 order
       Region 2akp B 210-210 disorder
 Evidence X-RAY 4asb A Reference
       Region 4asb A 1-1 disorder
       Region 4asb A 2-214 order
       Region 4asb A 215-220 disorder
 Evidence X-RAY 2brc A Reference
       Region 2brc A 1-214 order
 Evidence X-RAY 2bre A Reference
       Region 2bre A 1-1 disorder
       Region 2bre A 2-213 order
       Region 2bre A 214-219 disorder
 Evidence X-RAY 2bre B Reference
       Region 2bre B 1-1 disorder
       Region 2bre B 2-219 order
 Evidence X-RAY 3c0e A Reference
       Region 3c0e A 1-214 order
       Region 3c0e A 215-220 disorder
 Evidence X-RAY 3c11 A Reference
       Region 3c11 A 1-214 order
       Region 3c11 A 215-220 disorder
 Evidence X-RAY 2fxs A Reference
       Region 2fxs A 1-1 disorder
       Region 2fxs A 2-214 order
       Region 2fxs A 215-220 disorder
 Evidence X-RAY 2iws A Reference
       Region 2iws A 1-96 order
       Region 2iws A 97-99 disorder
       Region 2iws A 100-213 order
       Region 2iws A 214-214 disorder
 Evidence X-RAY 2iwu A Reference
       Region 2iwu A 1-214 order
 Evidence X-RAY 2iwx A Reference
       Region 2iwx A 1-214 order
 Evidence X-RAY 2vwc A Reference
       Region 2vwc A 1-1 disorder
       Region 2vwc A 2-214 order
       Region 2vwc A 215-219 disorder
 Evidence X-RAY 1zw9 A Reference
       Region 1zw9 A 1-1 disorder
       Region 1zw9 A 2-91 order
       Region 1zw9 A 92-98 disorder
       Region 1zw9 A 99-214 order
       Region 1zw9 A 215-220 disorder
 Evidence X-RAY 1zwh A Reference
       Region 1zwh A 1-1 disorder
       Region 1zwh A 2-214 order
       Region 1zwh A 215-220 disorder
 Evidence X-RAY 4as9 A Reference
       Region 4as9 A 1-1 disorder
       Region 4as9 A 2-214 order
       Region 4as9 A 215-220 disorder
 Evidence X-RAY 4ce3 A Reference
       Region 4ce3 A 1-214 order
 Evidence X-RAY 2xd6 A Reference
       Region 2xd6 A 1-214 order
 Evidence X-RAY 2yga A Reference
       Region 2yga A 1-214 order
       Region 2yga A 215-220 disorder
 Evidence X-RAY 2yge A Reference
       Region 2yge A 1-214 order
       Region 2yge A 215-220 disorder
 Evidence X-RAY 2ygf A Reference
       Region 2ygf A 1-1 disorder
       Region 2ygf A 2-214 order
       Region 2ygf A 215-220 disorder
Seq 1-220 Homo dimer :
 Evidence X-RAY 1a4h A Reference
       Region 1a4h A 1-214 order
       Region 1a4h A 215-220 disorder
 Evidence X-RAY 1ah6 A Reference
       Region 1ah6 A 1-1 disorder
       Region 1ah6 A 2-214 order
       Region 1ah6 A 215-220 disorder
 Evidence X-RAY 1ah8 A Reference
       Region 1ah8 A 1-1 disorder
       Region 1ah8 A 2-216 order
       Region 1ah8 A 217-220 disorder
 Evidence X-RAY 1ah8 B Reference
       Region 1ah8 B 1-1 disorder
       Region 1ah8 B 2-219 order
       Region 1ah8 B 220-220 disorder
 Evidence X-RAY 1am1 A Reference
       Region 1am1 A 2-214 order
 Evidence X-RAY 1amw A Reference
       Region 1amw A 1-1 disorder
       Region 1amw A 2-214 order
 Evidence X-RAY 4asa A Reference
       Region 4asa A 1-1 disorder
       Region 4asa A 2-214 order
       Region 4asa A 215-220 disorder
 Evidence X-RAY 4asf A Reference
       Region 4asf A 1-1 disorder
       Region 4asf A 2-214 order
       Region 4asf A 215-220 disorder
 Evidence X-RAY 4asg A Reference
       Region 4asg A 1-1 disorder
       Region 4asg A 2-214 order
       Region 4asg A 215-220 disorder
 Evidence X-RAY 1bgq A Reference
       Region 1bgq A 1-214 order
 Evidence X-RAY 4ce1 A Reference
       Region 4ce1 A 1-214 order
 Evidence X-RAY 4ce2 A Reference
       Region 4ce2 A 1-214 order
 Evidence X-RAY 2cgf A Reference
       Region 2cgf A 1-1 disorder
       Region 2cgf A 2-213 order
       Region 2cgf A 214-214 disorder
 Evidence X-RAY 2wep A Reference
       Region 2wep A 1-214 order
       Region 2wep A 215-220 disorder
 Evidence X-RAY 2weq A Reference
       Region 2weq A 1-1 disorder
       Region 2weq A 2-214 order
       Region 2weq A 215-220 disorder
 Evidence X-RAY 2wer A Reference
       Region 2wer A 1-214 order
       Region 2wer A 215-220 disorder
 Evidence X-RAY 2wer B Reference
       Region 2wer B 1-214 order
       Region 2wer B 215-220 disorder
 Evidence X-RAY 2xx2 A Reference
       Region 2xx2 A 1-214 order
 Evidence X-RAY 2xx2 D Reference
       Region 2xx2 D 1-214 order
 Evidence X-RAY 2xx2 B Reference
       Region 2xx2 B 1-214 order
 Evidence X-RAY 2xx2 C Reference
       Region 2xx2 C 1-214 order
 Evidence X-RAY 2xx4 A Reference
       Region 2xx4 A 1-96 order
       Region 2xx4 A 97-99 disorder
       Region 2xx4 A 100-214 order
 Evidence X-RAY 2xx5 A Reference
       Region 2xx5 A 1-94 order
       Region 2xx5 A 95-97 disorder
       Region 2xx5 A 98-214 order
Seq 1-677 Hetero tetramer : P28707
 Evidence X-RAY 2cg9 A Reference
       Region 2cg9 A 1-1 disorder
       Region 2cg9 A 2-216 order
       Region 2cg9 A 217-261 disorder
       Region 2cg9 A 262-329 order
       Region 2cg9 A 330-338 disorder
       Region 2cg9 A 339-597 order
       Region 2cg9 A 598-610 disorder
       Region 2cg9 A 611-677 order
 Evidence X-RAY 2cg9 B Reference
       Region 2cg9 B 1-1 disorder
       Region 2cg9 B 2-216 order
       Region 2cg9 B 217-261 disorder
       Region 2cg9 B 262-597 order
       Region 2cg9 B 598-610 disorder
       Region 2cg9 B 611-677 order
Seq 272-530 Hetero dimer : Q12449
 Evidence X-RAY 1usu A Reference
       Region 1usu A 273-334 order
       Region 1usu A 335-338 disorder
       Region 1usu A 339-378 order
       Region 1usu A 379-384 disorder
       Region 1usu A 385-527 order
       Region 1usu A 528-530 disorder
 Evidence X-RAY 1usv A Reference
       Region 1usv A 272-272 disorder
       Region 1usv A 273-332 order
       Region 1usv A 333-336 disorder
       Region 1usv A 337-527 order
       Region 1usv A 528-530 disorder
 Evidence X-RAY 1usv C Reference
       Region 1usv C 272-330 order
       Region 1usv C 331-336 disorder
       Region 1usv C 337-378 order
       Region 1usv C 379-381 disorder
       Region 1usv C 382-527 order
       Region 1usv C 528-530 disorder
 Evidence X-RAY 1usv E Reference
       Region 1usv E 272-331 order
       Region 1usv E 332-336 disorder
       Region 1usv E 337-527 order
       Region 1usv E 528-530 disorder
 Evidence X-RAY 1usv G Reference
       Region 1usv G 272-329 order
       Region 1usv G 330-336 disorder
       Region 1usv G 337-526 order
       Region 1usv G 527-530 disorder
Seq 273-560 Monomer :
 Evidence X-RAY 1hk7 A Reference
       Region 1hk7 A 273-377 order
       Region 1hk7 A 378-384 disorder
       Region 1hk7 A 385-527 order
       Region 1hk7 A 528-560 disorder
 Evidence X-RAY 1hk7 B Reference
       Region 1hk7 B 273-331 order
       Region 1hk7 B 332-340 disorder
       Region 1hk7 B 341-528 order
       Region 1hk7 B 529-560 disorder
Seq 273-677 Homo hexamer :
 Evidence X-RAY 2cge A Reference
       Region 2cge A 273-677 order
 Evidence X-RAY 2cge B Reference
       Region 2cge B 273-677 order
 Evidence X-RAY 2cge D Reference
       Region 2cge D 273-677 order
Seq 439-679 Homo tetramer :
 Evidence X-RAY 8oxu A Reference
       Region 8oxu A 439-596 order
       Region 8oxu A 597-604 disorder
       Region 8oxu A 605-677 order
       Region 8oxu A 678-679 disorder
 Evidence X-RAY 8oxu B Reference
       Region 8oxu B 439-598 order
       Region 8oxu B 599-604 disorder
       Region 8oxu B 605-677 order
       Region 8oxu B 678-679 disorder
 Evidence X-RAY 8oxu C Reference
       Region 8oxu C 439-597 order
       Region 8oxu C 598-604 disorder
       Region 8oxu C 605-679 order
 Evidence X-RAY 8oxu D Reference
       Region 8oxu D 439-598 order
       Region 8oxu D 599-604 disorder
       Region 8oxu D 605-677 order
       Region 8oxu D 678-679 disorder
Seqdisorder 678-709
 Evidence X-RAY Residues 678-709, which provide the C-terminal EEVD binding sequence for TPR-domain co-chaperones, are disordered. Reference
       Region 678-709 disorder
Seq 698-709 Hetero dimer : P38825
 Evidence X-RAY 3fp2 Q Reference
       Region 3fp2 Q 698-704 disorder
       Region 3fp2 Q 705-709 order
Seq 701-709 Hetero dimer : IID50204Complex
 Evidence NMR 2lsv B Reference
       Region 2lsv B 701-709 order
Seq 702-709 Hetero dimer : Q14318
 Evidence X-RAY 5mgx A Reference
       Region 5mgx A 702-709 order
 Evidence X-RAY 5mgx B Reference
       Region 5mgx B 702-709 order
 Evidence X-RAY 5mgx C Reference
       Region 5mgx C 702-703 disorder
       Region 5mgx C 704-709 order
 Evidence X-RAY 5mgx D Reference
       Region 5mgx D 702-703 disorder
       Region 5mgx D 704-707 order
       Region 5mgx D 708-709 disorder
SeqProS verified 701-709 TPR repeat-binding Hetero dimer : IID50204Complex
       Region 2lsv B 701-709 order
       Region 678-709 disorder
SeqProS verified 702-709 TPR repeat-binding Hetero dimer : Q14318
       Region 5mgx A 702-709 order
       Region 5mgx B 702-709 order
       Region 5mgx C 704-709 order
       Region 5mgx D 704-707 order
       Region 678-709 disorder
SeqProS verified 705-709 TPR repeat-binding Hetero dimer : P38825
       Region 3fp2 Q 705-709 order
       Region 678-709 disorder
Seqphosphorylation
    657-657 Phosphoserine
 
Prediction
NeProc
Disorder 1-4,209-264,533-542,601-608,680-709
Order 5-208,265-532,543-600,609-679
ProS 209-216,259-264,538-542,706-709
AlphaFold
Disorder 1-2,109-115,118-118,215-261,384-385,679-709
Order 3-108,116-117,119-214,262-383,386-678
SEG 206-269 ,529-548 ,601-609 ,679-701
Function
Function in SwissProt
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. The nucleotide-free form of the dimer is found in an open conformation in which the N-termini are not dimerized and the complex is ready for client protein binding. Binding of ATP induces large conformational changes, resulting in the formation of a ring-like closed structure in which the N-terminal domains associate intramolecularly with the middle domain and also dimerize with each other, stimulating their intrinsic ATPase activity and acting as a clamp on the substrate. Finally, ATP hydrolysis results in the release of the substrate. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for growth at high temperatures.