IID50422
Uniprot P02829
Protein ATP-dependent molecular chaperone HSP82
Gene HSP82
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence
LLPS
Network
xml
rdf
Structure
atLeast majority ProS Experiment
:order disorder conflict PDB cluster ProS Pfam Domain SEG
709
order/disorder by at least rule
disorder by at least rule
order/disorder by majority rule
Seq 1-214 Homo tetramer :
Region 2vw5 A 1-214 order
Region 2vw5 B 1-214 order
Region 2vw5 C 1-214 order
Region 2vw5 D 1-214 order
Seq 1-214 Hetero dimer : Q16543
Region 1us7 A 1-1 disorder
Region 1us7 A 2-207 order
Region 1us7 A 208-214 disorder
Region 2akp A 25-26 disorder
Region 2akp A 27-210 order
Region 2akp B 25-28 disorder
Region 2akp B 29-209 order
Region 2akp B 210-210 disorder
Region 4asb A 1-1 disorder
Region 4asb A 2-214 order
Region 4asb A 215-220 disorder
Region 2brc A 1-214 order
Region 2bre A 1-1 disorder
Region 2bre A 2-213 order
Region 2bre A 214-219 disorder
Region 2bre B 1-1 disorder
Region 2bre B 2-219 order
Region 3c0e A 1-214 order
Region 3c0e A 215-220 disorder
Region 3c11 A 1-214 order
Region 3c11 A 215-220 disorder
Region 2fxs A 1-1 disorder
Region 2fxs A 2-214 order
Region 2fxs A 215-220 disorder
Region 2iws A 97-99 disorder
Region 2iws A 100-213 order
Region 2iws A 214-214 disorder
Region 2iwu A 1-214 order
Region 2iwx A 1-214 order
Region 2vwc A 1-1 disorder
Region 2vwc A 2-214 order
Region 2vwc A 215-219 disorder
Region 1zw9 A 1-1 disorder
Region 1zw9 A 92-98 disorder
Region 1zw9 A 99-214 order
Region 1zw9 A 215-220 disorder
Region 1zwh A 1-1 disorder
Region 1zwh A 2-214 order
Region 1zwh A 215-220 disorder
Region 4as9 A 1-1 disorder
Region 4as9 A 2-214 order
Region 4as9 A 215-220 disorder
Region 4ce3 A 1-214 order
Region 2xd6 A 1-214 order
Region 2yga A 1-214 order
Region 2yga A 215-220 disorder
Region 2yge A 1-214 order
Region 2yge A 215-220 disorder
Region 2ygf A 1-1 disorder
Region 2ygf A 2-214 order
Region 2ygf A 215-220 disorder
Region 1a4h A 1-214 order
Region 1a4h A 215-220 disorder
Region 1ah6 A 1-1 disorder
Region 1ah6 A 2-214 order
Region 1ah6 A 215-220 disorder
Region 1ah8 A 1-1 disorder
Region 1ah8 A 2-216 order
Region 1ah8 A 217-220 disorder
Region 1ah8 B 1-1 disorder
Region 1ah8 B 2-219 order
Region 1ah8 B 220-220 disorder
Region 1am1 A 2-214 order
Region 1amw A 1-1 disorder
Region 1amw A 2-214 order
Region 4asa A 1-1 disorder
Region 4asa A 2-214 order
Region 4asa A 215-220 disorder
Region 4asf A 1-1 disorder
Region 4asf A 2-214 order
Region 4asf A 215-220 disorder
Region 4asg A 1-1 disorder
Region 4asg A 2-214 order
Region 4asg A 215-220 disorder
Region 1bgq A 1-214 order
Region 4ce1 A 1-214 order
Region 4ce2 A 1-214 order
Region 2cgf A 1-1 disorder
Region 2cgf A 2-213 order
Region 2cgf A 214-214 disorder
Region 2wep A 1-214 order
Region 2wep A 215-220 disorder
Region 2weq A 1-1 disorder
Region 2weq A 2-214 order
Region 2weq A 215-220 disorder
Region 2wer A 1-214 order
Region 2wer A 215-220 disorder
Region 2wer B 1-214 order
Region 2wer B 215-220 disorder
Region 2xx2 A 1-214 order
Region 2xx2 D 1-214 order
Region 2xx2 B 1-214 order
Region 2xx2 C 1-214 order
Region 2xx4 A 97-99 disorder
Region 2xx4 A 100-214 order
Region 2xx5 A 95-97 disorder
Region 2xx5 A 98-214 order
Seq 1-677 Hetero tetramer : P28707
Region 2cg9 A 1-1 disorder
Region 2cg9 A 2-216 order
Region 2cg9 A 217-261 disorder
Region 2cg9 A 262-329 order
Region 2cg9 A 330-338 disorder
Region 2cg9 A 339-597 order
Region 2cg9 A 598-610 disorder
Region 2cg9 A 611-677 order
Region 2cg9 B 1-1 disorder
Region 2cg9 B 2-216 order
Region 2cg9 B 217-261 disorder
Region 2cg9 B 262-597 order
Region 2cg9 B 598-610 disorder
Region 2cg9 B 611-677 order
Seq 272-530 Hetero dimer : Q12449
Region 1usu A 273-334 order
Region 1usu A 335-338 disorder
Region 1usu A 339-378 order
Region 1usu A 379-384 disorder
Region 1usu A 385-527 order
Region 1usu A 528-530 disorder
Region 1usv A 272-272 disorder
Region 1usv A 273-332 order
Region 1usv A 333-336 disorder
Region 1usv A 337-527 order
Region 1usv A 528-530 disorder
Region 1usv C 272-330 order
Region 1usv C 331-336 disorder
Region 1usv C 337-378 order
Region 1usv C 379-381 disorder
Region 1usv C 382-527 order
Region 1usv C 528-530 disorder
Region 1usv E 272-331 order
Region 1usv E 332-336 disorder
Region 1usv E 337-527 order
Region 1usv E 528-530 disorder
Region 1usv G 272-329 order
Region 1usv G 330-336 disorder
Region 1usv G 337-526 order
Region 1usv G 527-530 disorder
Region 1hk7 A 273-377 order
Region 1hk7 A 378-384 disorder
Region 1hk7 A 385-527 order
Region 1hk7 A 528-560 disorder
Region 1hk7 B 273-331 order
Region 1hk7 B 332-340 disorder
Region 1hk7 B 341-528 order
Region 1hk7 B 529-560 disorder
Seq 273-677 Homo hexamer :
Region 2cge A 273-677 order
Region 2cge B 273-677 order
Region 2cge D 273-677 order
Seq 439-679 Homo tetramer :
Region 8oxu A 439-596 order
Region 8oxu A 597-604 disorder
Region 8oxu A 605-677 order
Region 8oxu A 678-679 disorder
Region 8oxu B 439-598 order
Region 8oxu B 599-604 disorder
Region 8oxu B 605-677 order
Region 8oxu B 678-679 disorder
Region 8oxu C 439-597 order
Region 8oxu C 598-604 disorder
Region 8oxu C 605-679 order
Region 8oxu D 439-598 order
Region 8oxu D 599-604 disorder
Region 8oxu D 605-677 order
Region 8oxu D 678-679 disorder
Seq 698-709 Hetero dimer : P38825
Region 3fp2 Q 698-704 disorder
Region 3fp2 Q 705-709 order
Seq 701-709 Hetero dimer : IID50204 Complex
Region 2lsv B 701-709 order
Seq 702-709 Hetero dimer : Q14318
Region 5mgx A 702-709 order
Region 5mgx B 702-709 order
Region 5mgx C 702-703 disorder
Region 5mgx C 704-709 order
Region 5mgx D 702-703 disorder
Region 5mgx D 704-707 order
Region 5mgx D 708-709 disorder
Seq ProS verified 701-709
Hetero dimer : IID50204 Complex
Region 2lsv B 701-709 order
Seq ProS verified 702-709
Hetero dimer : Q14318
Region 5mgx A 702-709 order
Region 5mgx B 702-709 order
Region 5mgx C 704-709 order
Region 5mgx D 704-707 order
Seq ProS verified 705-709
Hetero dimer : P38825
Region 3fp2 Q 705-709 order
Prediction
Disorder 1-4,209-264,533-542,601-608,680-709
Order 5-208,265-532,543-600,609-679
ProS 209-216,259-264,538-542,706-709
Disorder 1-2,109-115,118-118,215-261,384-385,679-709
Order 3-108,116-117,119-214,262-383,386-678
SEG 206-269
,529-548
,601-609
,679-701
Function
Function in SwissProt
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. The nucleotide-free form of the dimer is found in an open conformation in which the N-termini are not dimerized and the complex is ready for client protein binding. Binding of ATP induces large conformational changes, resulting in the formation of a ring-like closed structure in which the N-terminal domains associate intramolecularly with the middle domain and also dimerize with each other, stimulating their intrinsic ATPase activity and acting as a clamp on the substrate. Finally, ATP hydrolysis results in the release of the substrate. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for growth at high temperatures.