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IID50423
 UniprotP03069
ProteinGeneral control transcription factor GCN4
GeneGCN4
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
281
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-134
 Evidence NMR The 1H,15N-HSQC spectra of each individual AD (Gcn4 1-100 and 101-134) overlay almost perfectly with the spectrum of a construct containing both ADs (residues 1-134), indicating that the two regions are structurally independent (Fig S1A). In all three spectra, the dispersion of resonances is over a narrow range in the 1HN-dimension, indicating that both Gcn4 ADs are intrinsically disordered in the absence of binding partners. Reference
       Region 1-134 disorder
Seq 101-134 Hetero dimer : P19659
 Evidence NMR 2lpb B Reference
       Region 2lpb B 101-134 order
Seq 220-281 Homo dimer :
 Evidence X-RAY 1dgc A Reference
       Region 1dgc A 220-226 disorder
       Region 1dgc A 227-281 order
 Evidence X-RAY 2dgc A Reference
       Region 2dgc A 220-228 disorder
       Region 2dgc A 229-277 order
       Region 2dgc A 278-281 disorder
 Evidence X-RAY 1ysa C Reference
       Region 1ysa C 226-281 order
 Evidence X-RAY 1ysa D Reference
       Region 1ysa D 226-280 order
       Region 1ysa D 281-281 disorder
Seq 247-281 Monomer :
 Evidence X-RAY 6o2e A Reference
       Region 6o2e A 249-279 order
 Evidence X-RAY 6o2f A Reference
       Region 6o2f A 249-279 order
 Evidence NMR 1zta A Reference
       Region 1zta A 247-281 order
       Region 1zta A 247-249 high_rmsd
       Region 1zta A 280-281 high_rmsd
Seq 249-272 Hetero dodecamer : O28303
 Evidence X-RAY 2wg5 A Reference
       Region 2wg5 A 249-249 disorder
       Region 2wg5 A 250-272 order
 Evidence X-RAY 2wg5 B Reference
       Region 2wg5 B 249-249 disorder
       Region 2wg5 B 250-272 order
 Evidence X-RAY 2wg5 C Reference
       Region 2wg5 C 249-249 disorder
       Region 2wg5 C 250-272 order
 Evidence X-RAY 2wg5 D Reference
       Region 2wg5 D 249-249 disorder
       Region 2wg5 D 250-272 order
 Evidence X-RAY 2wg5 E Reference
       Region 2wg5 E 249-249 disorder
       Region 2wg5 E 250-272 order
 Evidence X-RAY 2wg5 F Reference
       Region 2wg5 F 249-249 disorder
       Region 2wg5 F 250-272 order
Seq 249-272 Hetero dodecamer : O28303
 Evidence X-RAY 2wg6 A Reference
       Region 2wg6 A 249-249 disorder
       Region 2wg6 A 250-272 order
 Evidence X-RAY 2wg6 B Reference
       Region 2wg6 B 249-249 disorder
       Region 2wg6 B 250-272 order
 Evidence X-RAY 2wg6 C Reference
       Region 2wg6 C 249-249 disorder
       Region 2wg6 C 250-272 order
 Evidence X-RAY 2wg6 D Reference
       Region 2wg6 D 249-249 disorder
       Region 2wg6 D 250-272 order
 Evidence X-RAY 2wg6 E Reference
       Region 2wg6 E 249-249 disorder
       Region 2wg6 E 250-272 order
 Evidence X-RAY 2wg6 F Reference
       Region 2wg6 F 249-249 disorder
       Region 2wg6 F 250-272 order
Seq 249-272 Hetero dodecamer : O28303
 Evidence X-RAY 2wg5 G Reference
       Region 2wg5 G 249-249 disorder
       Region 2wg5 G 250-272 order
 Evidence X-RAY 2wg5 H Reference
       Region 2wg5 H 249-249 disorder
       Region 2wg5 H 250-272 order
 Evidence X-RAY 2wg5 I Reference
       Region 2wg5 I 249-249 disorder
       Region 2wg5 I 250-272 order
 Evidence X-RAY 2wg5 J Reference
       Region 2wg5 J 249-249 disorder
       Region 2wg5 J 250-272 order
 Evidence X-RAY 2wg5 K Reference
       Region 2wg5 K 249-249 disorder
       Region 2wg5 K 250-272 order
 Evidence X-RAY 2wg5 L Reference
       Region 2wg5 L 249-249 disorder
       Region 2wg5 L 250-272 order
Seq 249-272 Hetero dodecamer : O28303
 Evidence X-RAY 2wg6 G Reference
       Region 2wg6 G 249-249 disorder
       Region 2wg6 G 250-272 order
 Evidence X-RAY 2wg6 H Reference
       Region 2wg6 H 249-249 disorder
       Region 2wg6 H 250-272 order
 Evidence X-RAY 2wg6 I Reference
       Region 2wg6 I 249-249 disorder
       Region 2wg6 I 250-272 order
 Evidence X-RAY 2wg6 J Reference
       Region 2wg6 J 249-249 disorder
       Region 2wg6 J 250-272 order
 Evidence X-RAY 2wg6 K Reference
       Region 2wg6 K 249-249 disorder
       Region 2wg6 K 250-272 order
 Evidence X-RAY 2wg6 L Reference
       Region 2wg6 L 249-249 disorder
       Region 2wg6 L 250-272 order
Seq 249-276 Hetero nonamer : P04578
 Evidence X-RAY 1gzl A Reference
       Region 1gzl A 249-276 order
Seq 249-276 Hetero nonamer : P04578
 Evidence X-RAY 1gzl B Reference
       Region 1gzl B 249-276 order
Seq 249-277 Hetero tetramer : P58772
 Evidence X-RAY 2efs A Reference
       Region 2efs A 249-249 disorder
       Region 2efs A 250-277 order
 Evidence X-RAY 2efs B Reference
       Region 2efs B 249-249 disorder
       Region 2efs B 250-277 order
Seq 249-277 Hetero tetramer : P58772
 Evidence X-RAY 2efr C Reference
       Region 2efr C 249-249 disorder
       Region 2efr C 250-277 order
 Evidence X-RAY 2efr D Reference
       Region 2efr D 249-277 order
Seq 249-277 Hetero dimer : P04578
 Evidence X-RAY 6psa A Reference
       Region 6psa A 249-277 order
Seq 249-277 Hetero tetramer : P58772
 Evidence X-RAY 2efs C Reference
       Region 2efs C 249-249 disorder
       Region 2efs C 250-277 order
 Evidence X-RAY 2efs D Reference
       Region 2efs D 249-249 disorder
       Region 2efs D 250-277 order
Seq 249-277 Hetero tetramer : P58772
 Evidence X-RAY 2efr A Reference
       Region 2efr A 249-277 order
 Evidence X-RAY 2efr B Reference
       Region 2efr B 249-249 disorder
       Region 2efr B 250-277 order
Seq 249-278 Hetero tetramer : Q9HXT9
 Evidence X-RAY 3i5c A Reference
       Region 3i5c A 249-278 order
 Evidence X-RAY 3i5c B Reference
       Region 3i5c B 249-278 order
Seq 249-279 Hetero tetramer : P08670
 Evidence X-RAY 1gk6 A Reference
       Region 1gk6 A 249-249 disorder
       Region 1gk6 A 250-279 order
 Evidence X-RAY 1gk6 B Reference
       Region 1gk6 B 249-249 disorder
       Region 1gk6 B 250-279 order
Seq 249-281 Homo tetramer :
 Evidence X-RAY 2b1f A Reference
       Region 2b1f A 251-279 order
       Region 2b1f A 280-281 disorder
 Evidence X-RAY 2b1f B Reference
       Region 2b1f B 251-280 order
       Region 2b1f B 281-281 disorder
 Evidence X-RAY 2b1f C Reference
       Region 2b1f C 251-279 order
       Region 2b1f C 280-281 disorder
 Evidence X-RAY 2b1f D Reference
       Region 2b1f D 251-278 order
       Region 2b1f D 279-281 disorder
 Evidence X-RAY 2b22 A Reference
       Region 2b22 A 251-278 order
       Region 2b22 A 279-281 disorder
 Evidence X-RAY 2bni A Reference
       Region 2bni A 249-249 disorder
       Region 2bni A 250-278 order
       Region 2bni A 279-281 disorder
 Evidence X-RAY 2bni B Reference
       Region 2bni B 249-281 order
 Evidence X-RAY 2bni C Reference
       Region 2bni C 249-281 order
 Evidence X-RAY 2bni D Reference
       Region 2bni D 249-249 disorder
       Region 2bni D 250-280 order
       Region 2bni D 281-281 disorder
 Evidence X-RAY 2cce A Reference
       Region 2cce A 249-249 disorder
       Region 2cce A 250-280 order
       Region 2cce A 281-281 disorder
 Evidence X-RAY 2cce B Reference
       Region 2cce B 249-249 disorder
       Region 2cce B 250-280 order
       Region 2cce B 281-281 disorder
 Evidence X-RAY 2ccf A Reference
       Region 2ccf A 249-279 order
       Region 2ccf A 280-281 disorder
 Evidence X-RAY 2ccf B Reference
       Region 2ccf B 249-280 order
       Region 2ccf B 281-281 disorder
 Evidence X-RAY 2ccn A Reference
       Region 2ccn A 249-249 disorder
       Region 2ccn A 250-281 order
 Evidence X-RAY 2ccn B Reference
       Region 2ccn B 249-281 order
 Evidence X-RAY 3ck4 A Reference
       Region 3ck4 A 251-278 order
       Region 3ck4 A 279-281 disorder
 Evidence X-RAY 3ck4 B Reference
       Region 3ck4 B 251-280 order
       Region 3ck4 B 281-281 disorder
 Evidence X-RAY 3ck4 C Reference
       Region 3ck4 C 251-281 order
 Evidence X-RAY 3ck4 D Reference
       Region 3ck4 D 251-281 order
 Evidence X-RAY 3ck4 E Reference
       Region 3ck4 E 251-279 order
       Region 3ck4 E 280-281 disorder
 Evidence X-RAY 3ck4 F Reference
       Region 3ck4 F 251-281 order
 Evidence X-RAY 3ck4 G Reference
       Region 3ck4 G 251-280 order
       Region 3ck4 G 281-281 disorder
 Evidence X-RAY 3ck4 H Reference
       Region 3ck4 H 251-278 order
       Region 3ck4 H 279-281 disorder
 Evidence X-RAY 3ck4 I Reference
       Region 3ck4 I 251-278 order
       Region 3ck4 I 279-281 disorder
 Evidence X-RAY 3ck4 J Reference
       Region 3ck4 J 251-281 order
 Evidence X-RAY 3ck4 K Reference
       Region 3ck4 K 251-281 order
 Evidence X-RAY 3ck4 L Reference
       Region 3ck4 L 251-278 order
       Region 3ck4 L 279-281 disorder
 Evidence X-RAY 3crp E Reference
       Region 3crp E 251-278 order
       Region 3crp E 279-281 disorder
 Evidence X-RAY 1gcl A Reference
       Region 1gcl A 249-279 order
       Region 1gcl A 280-281 disorder
 Evidence X-RAY 1gcl B Reference
       Region 1gcl B 249-279 order
       Region 1gcl B 280-281 disorder
 Evidence X-RAY 1gcl C Reference
       Region 1gcl C 249-279 order
       Region 1gcl C 280-281 disorder
 Evidence X-RAY 1gcl D Reference
       Region 1gcl D 249-279 order
       Region 1gcl D 280-281 disorder
 Evidence X-RAY 2nrn A Reference
       Region 2nrn A 251-278 order
       Region 2nrn A 279-281 disorder
 Evidence X-RAY 2nrn B Reference
       Region 2nrn B 251-281 order
 Evidence X-RAY 2nrn C Reference
       Region 2nrn C 251-279 order
       Region 2nrn C 280-281 disorder
 Evidence X-RAY 2nrn D Reference
       Region 2nrn D 251-281 order
 Evidence X-RAY 1unt A Reference
       Region 1unt A 249-280 order
       Region 1unt A 281-281 disorder
 Evidence X-RAY 1unt B Reference
       Region 1unt B 249-281 order
 Evidence X-RAY 1unu A Reference
       Region 1unu A 249-249 disorder
       Region 1unu A 250-280 order
       Region 1unu A 281-281 disorder
 Evidence X-RAY 1unu B Reference
       Region 1unu B 249-249 disorder
       Region 1unu B 250-280 order
       Region 1unu B 281-281 disorder
 Evidence X-RAY 1unv A Reference
       Region 1unv A 249-255 disorder
       Region 1unv A 256-280 order
       Region 1unv A 281-281 disorder
 Evidence X-RAY 1unv B Reference
       Region 1unv B 249-253 disorder
       Region 1unv B 254-278 order
       Region 1unv B 279-281 disorder
 Evidence X-RAY 1unw A Reference
       Region 1unw A 249-279 order
       Region 1unw A 280-281 disorder
 Evidence X-RAY 1unw B Reference
       Region 1unw B 249-279 order
       Region 1unw B 280-281 disorder
 Evidence X-RAY 1unx A Reference
       Region 1unx A 249-279 order
       Region 1unx A 280-281 disorder
 Evidence X-RAY 1unx B Reference
       Region 1unx B 249-281 order
 Evidence X-RAY 1uny A Reference
       Region 1uny A 249-274 order
       Region 1uny A 275-281 disorder
 Evidence X-RAY 1uny B Reference
       Region 1uny B 249-278 order
       Region 1uny B 279-281 disorder
 Evidence X-RAY 1unz A Reference
       Region 1unz A 249-250 disorder
       Region 1unz A 251-278 order
       Region 1unz A 279-281 disorder
 Evidence X-RAY 1unz B Reference
       Region 1unz B 249-250 disorder
       Region 1unz B 251-278 order
       Region 1unz B 279-281 disorder
 Evidence X-RAY 1uo0 A Reference
       Region 1uo0 A 249-279 order
       Region 1uo0 A 280-281 disorder
 Evidence X-RAY 1uo0 B Reference
       Region 1uo0 B 249-279 order
       Region 1uo0 B 280-281 disorder
 Evidence X-RAY 1uo1 A Reference
       Region 1uo1 A 249-279 order
       Region 1uo1 A 280-281 disorder
 Evidence X-RAY 1uo1 B Reference
       Region 1uo1 B 249-279 order
       Region 1uo1 B 280-281 disorder
 Evidence X-RAY 1uo2 A Reference
       Region 1uo2 A 249-280 order
       Region 1uo2 A 281-281 disorder
 Evidence X-RAY 1uo2 B Reference
       Region 1uo2 B 249-281 order
 Evidence X-RAY 1uo3 A Reference
       Region 1uo3 A 249-250 disorder
       Region 1uo3 A 251-280 order
       Region 1uo3 A 281-281 disorder
 Evidence X-RAY 1uo3 B Reference
       Region 1uo3 B 249-250 disorder
       Region 1uo3 B 251-280 order
       Region 1uo3 B 281-281 disorder
 Evidence X-RAY 1uo4 A Reference
       Region 1uo4 A 249-249 disorder
       Region 1uo4 A 250-280 order
       Region 1uo4 A 281-281 disorder
 Evidence X-RAY 1uo4 B Reference
       Region 1uo4 B 249-249 disorder
       Region 1uo4 B 250-280 order
       Region 1uo4 B 281-281 disorder
 Evidence X-RAY 1uo5 A Reference
       Region 1uo5 A 249-249 disorder
       Region 1uo5 A 250-280 order
       Region 1uo5 A 281-281 disorder
 Evidence X-RAY 1uo5 B Reference
       Region 1uo5 B 249-249 disorder
       Region 1uo5 B 250-280 order
       Region 1uo5 B 281-281 disorder
 Evidence X-RAY 1w5g A Reference
       Region 1w5g A 249-249 disorder
       Region 1w5g A 250-280 order
       Region 1w5g A 281-281 disorder
 Evidence X-RAY 1w5g B Reference
       Region 1w5g B 249-281 order
 Evidence X-RAY 1w5h A Reference
       Region 1w5h A 249-249 disorder
       Region 1w5h A 250-280 order
       Region 1w5h A 281-281 disorder
 Evidence X-RAY 1w5h B Reference
       Region 1w5h B 249-249 disorder
       Region 1w5h B 250-280 order
       Region 1w5h B 281-281 disorder
 Evidence X-RAY 1w5i A Reference
       Region 1w5i A 249-280 order
       Region 1w5i A 281-281 disorder
 Evidence X-RAY 1w5i B Reference
       Region 1w5i B 249-281 order
 Evidence X-RAY 1w5j A Reference
       Region 1w5j A 249-281 order
 Evidence X-RAY 1w5j B Reference
       Region 1w5j B 249-281 order
 Evidence X-RAY 1w5j C Reference
       Region 1w5j C 249-281 order
 Evidence X-RAY 1w5j D Reference
       Region 1w5j D 249-281 order
 Evidence X-RAY 1w5k A Reference
       Region 1w5k A 249-281 order
 Evidence X-RAY 1w5k B Reference
       Region 1w5k B 249-281 order
 Evidence X-RAY 1w5k C Reference
       Region 1w5k C 249-281 order
 Evidence X-RAY 1w5k D Reference
       Region 1w5k D 249-281 order
 Evidence X-RAY 1w5l A Reference
       Region 1w5l A 249-280 order
       Region 1w5l A 281-281 disorder
 Evidence X-RAY 1w5l B Reference
       Region 1w5l B 249-281 order
Seq 249-281 Homo dimer :
 Evidence X-RAY 2ahp A Reference
       Region 2ahp A 249-281 order
 Evidence X-RAY 2ahp B Reference
       Region 2ahp B 249-280 order
       Region 2ahp B 281-281 disorder
 Evidence X-RAY 4dmd A Reference
       Region 4dmd A 249-279 order
       Region 4dmd A 280-281 disorder
 Evidence X-RAY 4dmd B Reference
       Region 4dmd B 249-281 order
 Evidence X-RAY 4hu5 A Reference
       Region 4hu5 A 249-280 order
       Region 4hu5 A 281-281 disorder
 Evidence X-RAY 4hu5 B Reference
       Region 4hu5 B 249-278 order
       Region 4hu5 B 279-281 disorder
 Evidence X-RAY 4hu6 A Reference
       Region 4hu6 A 260-280 order
       Region 4hu6 A 281-281 disorder
 Evidence X-RAY 4hu6 B Reference
       Region 4hu6 B 260-279 order
       Region 4hu6 B 280-281 disorder
 Evidence X-RAY 4hu6 C Reference
       Region 4hu6 C 260-280 order
       Region 4hu6 C 281-281 disorder
 Evidence X-RAY 4hu6 D Reference
       Region 4hu6 D 260-280 order
       Region 4hu6 D 281-281 disorder
 Evidence X-RAY 3i1g A Reference
       Region 3i1g A 249-249 disorder
       Region 3i1g A 250-280 order
       Region 3i1g A 281-281 disorder
 Evidence NMR 5iew A Reference
       Region 5iew A 250-280 order
       Region 5iew A 280-280 high_rmsd
 Evidence NMR 5iew B Reference
       Region 5iew B 250-280 order
       Region 5iew B 280-280 high_rmsd
 Evidence NMR 5iiv A Reference
       Region 5iiv A 250-280 order
 Evidence NMR 5iiv B Reference
       Region 5iiv B 250-280 order
 Evidence X-RAY 3m48 A Reference
       Region 3m48 A 249-250 disorder
       Region 3m48 A 251-280 order
       Region 3m48 A 281-281 disorder
 Evidence X-RAY 4niz A Reference
       Region 4niz A 249-278 order
       Region 4niz A 279-281 disorder
 Evidence X-RAY 4niz B Reference
       Region 4niz B 249-280 order
       Region 4niz B 281-281 disorder
 Evidence X-RAY 4nj0 A Reference
       Region 4nj0 A 249-278 order
       Region 4nj0 A 279-281 disorder
 Evidence X-RAY 4nj0 B Reference
       Region 4nj0 B 249-281 order
 Evidence X-RAY 4nj1 A Reference
       Region 4nj1 A 249-279 order
       Region 4nj1 A 280-281 disorder
 Evidence X-RAY 4nj1 B Reference
       Region 4nj1 B 249-280 order
       Region 4nj1 B 281-281 disorder
 Evidence X-RAY 4nj2 A Reference
       Region 4nj2 A 249-281 order
 Evidence X-RAY 4nj2 B Reference
       Region 4nj2 B 249-281 order
 Evidence X-RAY 4tl1 A Reference
       Region 4tl1 A 249-257 order
       Region 4tl1 A 258-258 disorder
       Region 4tl1 A 259-281 order
 Evidence X-RAY 4tl1 B Reference
       Region 4tl1 B 249-257 order
       Region 4tl1 B 258-258 disorder
       Region 4tl1 B 259-280 order
       Region 4tl1 B 281-281 disorder
 Evidence X-RAY 1zii A Reference
       Region 1zii A 249-279 order
       Region 1zii A 280-281 disorder
 Evidence X-RAY 1zii B Reference
       Region 1zii B 249-279 order
       Region 1zii B 280-281 disorder
 Evidence X-RAY 1zik A Reference
       Region 1zik A 249-278 order
       Region 1zik A 279-281 disorder
 Evidence X-RAY 1zik B Reference
       Region 1zik B 249-278 order
       Region 1zik B 279-281 disorder
 Evidence X-RAY 1zil A Reference
       Region 1zil A 249-278 order
       Region 1zil A 279-281 disorder
 Evidence X-RAY 1zil B Reference
       Region 1zil B 249-278 order
       Region 1zil B 279-281 disorder
 Evidence X-RAY 2zta A Reference
       Region 2zta A 249-279 order
       Region 2zta A 280-281 disorder
 Evidence X-RAY 2zta B Reference
       Region 2zta B 249-279 order
       Region 2zta B 280-281 disorder
 Evidence X-RAY 6e52 A Reference
       Region 6e52 A 250-275 order
 Evidence X-RAY 6e52 B Reference
       Region 6e52 B 250-275 order
 Evidence NMR 1fmh A Reference
       Region 1fmh A 249-279 order
 Evidence NMR 1fmh B Reference
       Region 1fmh B 249-279 order
 Evidence NMR 5iir A Reference
       Region 5iir A 250-280 order
 Evidence NMR 5iir B Reference
       Region 5iir B 250-280 order
 Evidence NMR 2k8x A Reference
       Region 2k8x A 264-281 order
 Evidence NMR 2k8x B Reference
       Region 2k8x B 264-281 order
       Region 2k8x B 281-281 high_rmsd
 Evidence X-RAY 4owi A Reference
       Region 4owi A 249-278 order
 Evidence X-RAY 4owi B Reference
       Region 4owi B 249-278 order
Seq 249-281 Homo trimer :
 Evidence X-RAY 5app A Reference
       Region 5app A 250-250 disorder
       Region 5app A 251-276 order
 Evidence X-RAY 5app B Reference
       Region 5app B 250-276 order
 Evidence X-RAY 5app C Reference
       Region 5app C 250-276 order
 Evidence X-RAY 5apq A Reference
       Region 5apq A 250-278 order
       Region 5apq A 279-281 disorder
 Evidence X-RAY 5apq B Reference
       Region 5apq B 250-278 order
       Region 5apq B 279-281 disorder
 Evidence X-RAY 5apq C Reference
       Region 5apq C 250-278 order
       Region 5apq C 279-281 disorder
 Evidence X-RAY 5aps A Reference
       Region 5aps A 250-281 order
 Evidence X-RAY 5apt A Reference
       Region 5apt A 250-279 order
       Region 5apt A 280-281 disorder
 Evidence X-RAY 5apt B Reference
       Region 5apt B 250-281 order
 Evidence X-RAY 5apt C Reference
       Region 5apt C 250-281 order
 Evidence X-RAY 5apu A Reference
       Region 5apu A 250-279 order
       Region 5apu A 280-281 disorder
 Evidence X-RAY 5apu B Reference
       Region 5apu B 250-279 order
       Region 5apu B 280-281 disorder
 Evidence X-RAY 5apu C Reference
       Region 5apu C 250-281 order
 Evidence X-RAY 5apv D Reference
       Region 5apv D 250-279 order
       Region 5apv D 280-281 disorder
 Evidence X-RAY 5apv E Reference
       Region 5apv E 250-279 order
       Region 5apv E 280-281 disorder
 Evidence X-RAY 5apv F Reference
       Region 5apv F 250-279 order
       Region 5apv F 280-281 disorder
 Evidence X-RAY 5apv A Reference
       Region 5apv A 250-281 order
 Evidence X-RAY 5apv B Reference
       Region 5apv B 250-279 order
       Region 5apv B 280-281 disorder
 Evidence X-RAY 5apv C Reference
       Region 5apv C 250-281 order
 Evidence X-RAY 5apw A Reference
       Region 5apw A 250-280 order
       Region 5apw A 281-281 disorder
 Evidence X-RAY 5apw B Reference
       Region 5apw B 250-278 order
       Region 5apw B 279-281 disorder
 Evidence X-RAY 5apw C Reference
       Region 5apw C 250-278 order
       Region 5apw C 279-281 disorder
 Evidence X-RAY 5apx A Reference
       Region 5apx A 250-279 order
       Region 5apx A 280-281 disorder
 Evidence X-RAY 5apx B Reference
       Region 5apx B 250-279 order
       Region 5apx B 280-281 disorder
 Evidence X-RAY 5apx C Reference
       Region 5apx C 250-278 order
       Region 5apx C 279-281 disorder
 Evidence X-RAY 5apy A Reference
       Region 5apy A 250-279 order
       Region 5apy A 280-281 disorder
 Evidence X-RAY 5apy B Reference
       Region 5apy B 250-278 order
       Region 5apy B 279-281 disorder
 Evidence X-RAY 5apy C Reference
       Region 5apy C 250-278 order
       Region 5apy C 279-281 disorder
 Evidence X-RAY 4c46 A Reference
       Region 4c46 A 250-278 order
 Evidence X-RAY 4c46 B Reference
       Region 4c46 B 250-278 order
 Evidence X-RAY 4c46 C Reference
       Region 4c46 C 250-278 order
 Evidence X-RAY 1gcm A Reference
       Region 1gcm A 249-279 order
       Region 1gcm A 280-281 disorder
 Evidence X-RAY 1gcm B Reference
       Region 1gcm B 249-280 order
       Region 1gcm B 281-281 disorder
 Evidence X-RAY 1gcm C Reference
       Region 1gcm C 249-281 order
 Evidence X-RAY 3gjp A Reference
       Region 3gjp A 249-281 order
 Evidence X-RAY 3gjp B Reference
       Region 3gjp B 249-281 order
 Evidence X-RAY 3gjp C Reference
       Region 3gjp C 249-280 order
       Region 3gjp C 281-281 disorder
 Evidence X-RAY 1ij0 A Reference
       Region 1ij0 A 249-279 order
       Region 1ij0 A 280-281 disorder
 Evidence X-RAY 1ij0 B Reference
       Region 1ij0 B 249-279 order
       Region 1ij0 B 280-281 disorder
 Evidence X-RAY 1ij0 C Reference
       Region 1ij0 C 249-279 order
       Region 1ij0 C 280-281 disorder
 Evidence X-RAY 1ij1 A Reference
       Region 1ij1 A 249-279 order
       Region 1ij1 A 280-281 disorder
 Evidence X-RAY 1ij1 B Reference
       Region 1ij1 B 249-279 order
       Region 1ij1 B 280-281 disorder
 Evidence X-RAY 1ij1 C Reference
       Region 1ij1 C 249-279 order
       Region 1ij1 C 280-281 disorder
 Evidence X-RAY 1ij2 A Reference
       Region 1ij2 A 249-278 order
       Region 1ij2 A 279-281 disorder
 Evidence X-RAY 1ij2 B Reference
       Region 1ij2 B 249-280 order
       Region 1ij2 B 281-281 disorder
 Evidence X-RAY 1ij2 C Reference
       Region 1ij2 C 249-279 order
       Region 1ij2 C 280-281 disorder
 Evidence X-RAY 1ij3 A Reference
       Region 1ij3 A 249-280 order
       Region 1ij3 A 281-281 disorder
 Evidence X-RAY 1ij3 B Reference
       Region 1ij3 B 249-279 order
       Region 1ij3 B 280-281 disorder
 Evidence X-RAY 1ij3 C Reference
       Region 1ij3 C 249-279 order
       Region 1ij3 C 280-281 disorder
 Evidence X-RAY 3k7z A Reference
       Region 3k7z A 249-279 order
       Region 3k7z A 280-281 disorder
 Evidence X-RAY 3k7z B Reference
       Region 3k7z B 249-279 order
       Region 3k7z B 280-281 disorder
 Evidence X-RAY 3k7z C Reference
       Region 3k7z C 249-250 disorder
       Region 3k7z C 251-279 order
       Region 3k7z C 280-281 disorder
 Evidence X-RAY 2o7h A Reference
       Region 2o7h A 249-280 order
       Region 2o7h A 281-281 disorder
 Evidence X-RAY 2o7h B Reference
       Region 2o7h B 249-249 disorder
       Region 2o7h B 250-279 order
       Region 2o7h B 280-281 disorder
 Evidence X-RAY 2o7h C Reference
       Region 2o7h C 249-281 order
 Evidence X-RAY 2o7h D Reference
       Region 2o7h D 249-279 order
       Region 2o7h D 280-281 disorder
 Evidence X-RAY 2o7h E Reference
       Region 2o7h E 249-279 order
       Region 2o7h E 280-281 disorder
 Evidence X-RAY 2o7h F Reference
       Region 2o7h F 249-279 order
       Region 2o7h F 280-281 disorder
 Evidence X-RAY 1piq A Reference
       Region 1piq A 249-279 order
 Evidence X-RAY 1rb4 A Reference
       Region 1rb4 A 249-278 order
       Region 1rb4 A 279-281 disorder
 Evidence X-RAY 1rb4 B Reference
       Region 1rb4 B 249-280 order
       Region 1rb4 B 281-281 disorder
 Evidence X-RAY 1rb4 C Reference
       Region 1rb4 C 249-277 order
       Region 1rb4 C 278-281 disorder
 Evidence X-RAY 1rb5 A Reference
       Region 1rb5 A 249-281 order
 Evidence X-RAY 1rb5 B Reference
       Region 1rb5 B 249-281 order
 Evidence X-RAY 1rb5 C Reference
       Region 1rb5 C 249-280 order
       Region 1rb5 C 281-281 disorder
 Evidence X-RAY 1rb6 A Reference
       Region 1rb6 A 249-281 order
 Evidence X-RAY 1rb6 B Reference
       Region 1rb6 B 249-280 order
       Region 1rb6 B 281-281 disorder
 Evidence X-RAY 1rb6 C Reference
       Region 1rb6 C 249-279 order
       Region 1rb6 C 280-281 disorder
 Evidence X-RAY 1swi A Reference
       Region 1swi A 249-279 order
       Region 1swi A 280-281 disorder
 Evidence X-RAY 1swi B Reference
       Region 1swi B 249-278 order
       Region 1swi B 279-281 disorder
 Evidence X-RAY 1swi C Reference
       Region 1swi C 249-278 order
       Region 1swi C 279-281 disorder
 Evidence X-RAY 2wpy A Reference
       Region 2wpy A 249-280 order
       Region 2wpy A 281-281 disorder
 Evidence X-RAY 2wpz A Reference
       Region 2wpz A 249-279 order
       Region 2wpz A 280-281 disorder
 Evidence X-RAY 2wpz B Reference
       Region 2wpz B 249-280 order
       Region 2wpz B 281-281 disorder
 Evidence X-RAY 2wpz C Reference
       Region 2wpz C 249-281 order
 Evidence X-RAY 2wq0 A Reference
       Region 2wq0 A 249-249 disorder
       Region 2wq0 A 250-280 order
       Region 2wq0 A 281-281 disorder
 Evidence X-RAY 2wq1 A Reference
       Region 2wq1 A 249-280 order
       Region 2wq1 A 281-281 disorder
 Evidence X-RAY 2wq2 A Reference
       Region 2wq2 A 249-249 disorder
       Region 2wq2 A 250-279 order
       Region 2wq2 A 280-281 disorder
 Evidence X-RAY 2wq3 A Reference
       Region 2wq3 A 249-280 order
       Region 2wq3 A 281-281 disorder
 Evidence X-RAY 1zij A Reference
       Region 1zij A 249-281 order
 Evidence X-RAY 1zij B Reference
       Region 1zij B 249-281 order
 Evidence X-RAY 1zij C Reference
       Region 1zij C 249-281 order
 Evidence X-RAY 1zim A Reference
       Region 1zim A 249-280 order
       Region 1zim A 281-281 disorder
 Evidence X-RAY 1zim B Reference
       Region 1zim B 249-280 order
       Region 1zim B 281-281 disorder
 Evidence X-RAY 1zim C Reference
       Region 1zim C 249-280 order
       Region 1zim C 281-281 disorder
 Evidence X-RAY 6xne A Reference
       Region 6xne A 249-263 order
       Region 6xne A 264-264 disorder
       Region 6xne A 265-278 order
 Evidence X-RAY 6xne B Reference
       Region 6xne B 249-278 order
 Evidence X-RAY 6xne C Reference
       Region 6xne C 249-278 order
 Evidence X-RAY 6xnf A Reference
       Region 6xnf A 249-263 order
       Region 6xnf A 264-264 disorder
       Region 6xnf A 265-278 order
 Evidence X-RAY 6xnf B Reference
       Region 6xnf B 249-278 order
 Evidence X-RAY 6xnf C Reference
       Region 6xnf C 249-278 order
 Evidence X-RAY 6xnl A Reference
       Region 6xnl A 249-278 order
 Evidence X-RAY 6xnl B Reference
       Region 6xnl B 249-278 order
 Evidence X-RAY 6xnl C Reference
       Region 6xnl C 249-278 order
 Evidence X-RAY 6xnm A Reference
       Region 6xnm A 249-278 order
 Evidence X-RAY 6xnm B Reference
       Region 6xnm B 249-278 order
 Evidence X-RAY 6xnm C Reference
       Region 6xnm C 249-278 order
Seq 250-275 Hetero tetramer : A0A224B0L3
 Evidence X-RAY 6e95 A Reference
       Region 6e95 A 250-275 order
 Evidence X-RAY 6e95 B Reference
       Region 6e95 B 250-275 order
Seq 250-278 Hetero decamer : P49913,Q6TLP8
 Evidence X-RAY 7say A Reference
       Region 7say A 250-278 order
 Evidence X-RAY 7say B Reference
       Region 7say B 250-278 order
 Evidence X-RAY 7say C Reference
       Region 7say C 250-251 disorder
       Region 7say C 252-278 order
 Evidence X-RAY 7say D Reference
       Region 7say D 250-278 order
Seq 250-278
 Evidence X-RAY 2yo1 A Reference
       Region 2yo1 A 250-278 order
Seq 250-278 Hetero hexamer : Q8ZL64
 Evidence X-RAY 3zmf A Reference
       Region 3zmf A 250-278 order
Seq 250-278 Hetero hexamer : Q8ZL64
 Evidence X-RAY 3zmf C Reference
       Region 3zmf C 250-278 order
Seq 250-278 Hetero hexamer : Q8ZL64
 Evidence X-RAY 2yny A Reference
       Region 2yny A 250-278 order
 Evidence X-RAY 2yny B Reference
       Region 2yny B 250-278 order
 Evidence X-RAY 2yny C Reference
       Region 2yny C 250-278 order
Seq 250-278 Hetero hexamer : Q8ZL64
 Evidence X-RAY 3zmf B Reference
       Region 3zmf B 250-278 order
Seq 250-278
 Evidence 2yo1 B Reference
       Region 2yo1 B 250-278 order
Seq 250-278 Hetero hexamer : Q8ZL64
 Evidence X-RAY 2yo2 A Reference
       Region 2yo2 A 250-251 disorder
       Region 2yo2 A 252-278 order
Seq 250-278 Hetero hexamer : Q8ZL64
 Evidence X-RAY 2ynz A Reference
       Region 2ynz A 250-251 disorder
       Region 2ynz A 252-278 order
 Evidence X-RAY 2ynz B Reference
       Region 2ynz B 250-251 disorder
       Region 2ynz B 252-278 order
 Evidence X-RAY 2ynz C Reference
       Region 2ynz C 250-251 disorder
       Region 2ynz C 252-278 order
Seq 250-278
 Evidence X-RAY 2yo0 A Reference
       Region 2yo0 A 250-278 order
Seq 250-278
 Evidence X-RAY 2yo1 C Reference
       Region 2yo1 C 250-278 order
Seq 250-278 Hetero tetramer : Q6TLP8
 Evidence X-RAY 7saf A Reference
       Region 7saf A 250-278 order
 Evidence X-RAY 7saf B Reference
       Region 7saf B 250-278 order
Seq 250-278 Hetero hexamer : Q8ZL64
 Evidence X-RAY 2yo3 A Reference
       Region 2yo3 A 250-250 disorder
       Region 2yo3 A 251-278 order
 Evidence X-RAY 2yo3 B Reference
       Region 2yo3 B 250-278 order
 Evidence X-RAY 2yo3 C Reference
       Region 2yo3 C 250-278 order
Seq 250-279 Hetero nonamer : A1HT30
 Evidence X-RAY 5apz A Reference
       Region 5apz A 250-279 order
Seq 250-279 Hetero hexamer : P35254
 Evidence X-RAY 4g2k A Reference
       Region 4g2k A 250-279 order
 Evidence X-RAY 4g2k B Reference
       Region 4g2k B 250-279 order
 Evidence X-RAY 4g2k C Reference
       Region 4g2k C 250-250 disorder
       Region 4g2k C 251-279 order
Seq 250-281 Hetero tetramer : P24733
 Evidence X-RAY 3bas A Reference
       Region 3bas A 250-281 order
 Evidence X-RAY 3bas B Reference
       Region 3bas B 250-280 order
       Region 3bas B 281-281 disorder
Seq 250-281 Hetero tetramer : Q17042
 Evidence X-RAY 1nkn C Reference
       Region 1nkn C 250-281 order
 Evidence X-RAY 1nkn D Reference
       Region 1nkn D 250-280 order
       Region 1nkn D 281-281 disorder
Seq 250-281 Hetero tetramer : P24733
 Evidence X-RAY 3bat C Reference
       Region 3bat C 250-281 order
 Evidence X-RAY 3bat D Reference
       Region 3bat D 250-281 order
Seq 250-281 Hetero tetramer : P24733
 Evidence X-RAY 3bat A Reference
       Region 3bat A 250-281 order
 Evidence X-RAY 3bat B Reference
       Region 3bat B 250-280 order
       Region 3bat B 281-281 disorder
Seq 250-281 Hetero tetramer : Q17042
 Evidence X-RAY 1nkn A Reference
       Region 1nkn A 250-281 order
 Evidence X-RAY 1nkn B Reference
       Region 1nkn B 250-280 order
       Region 1nkn B 281-281 disorder
Seq 250-281 Hetero tetramer : Q96FJ2
 Evidence X-RAY 3p8m C Reference
       Region 3p8m C 250-278 order
       Region 3p8m C 279-281 disorder
 Evidence X-RAY 3p8m D Reference
       Region 3p8m D 250-278 order
       Region 3p8m D 279-281 disorder
Seq 251-281 Homo heptamer :
 Evidence X-RAY 2hy6 A Reference
       Region 2hy6 A 251-280 order
       Region 2hy6 A 281-281 disorder
 Evidence X-RAY 2hy6 B Reference
       Region 2hy6 B 251-280 order
       Region 2hy6 B 281-281 disorder
 Evidence X-RAY 2hy6 C Reference
       Region 2hy6 C 251-280 order
       Region 2hy6 C 281-281 disorder
 Evidence X-RAY 2hy6 D Reference
       Region 2hy6 D 251-281 order
 Evidence X-RAY 2hy6 E Reference
       Region 2hy6 E 251-280 order
       Region 2hy6 E 281-281 disorder
 Evidence X-RAY 2hy6 F Reference
       Region 2hy6 F 251-279 order
       Region 2hy6 F 280-281 disorder
 Evidence X-RAY 2hy6 G Reference
       Region 2hy6 G 251-279 order
       Region 2hy6 G 280-281 disorder
Seq 251-281 Homo tetramer :
 Evidence X-RAY 1ce9 A Reference
       Region 1ce9 A 251-281 order
 Evidence X-RAY 1ce9 B Reference
       Region 1ce9 B 251-281 order
 Evidence X-RAY 1ce9 C Reference
       Region 1ce9 C 251-281 order
 Evidence X-RAY 1ce9 D Reference
       Region 1ce9 D 251-281 order
 Evidence X-RAY 3crp A Reference
       Region 3crp A 251-279 order
       Region 3crp A 280-281 disorder
 Evidence X-RAY 3crp B Reference
       Region 3crp B 251-281 order
 Evidence X-RAY 3crp C Reference
       Region 3crp C 251-278 order
       Region 3crp C 279-281 disorder
 Evidence X-RAY 3crp D Reference
       Region 3crp D 251-279 order
       Region 3crp D 280-281 disorder
 Evidence X-RAY 2ipz A Reference
       Region 2ipz A 251-281 order
 Evidence X-RAY 2ipz B Reference
       Region 2ipz B 251-281 order
 Evidence X-RAY 2ipz C Reference
       Region 2ipz C 251-281 order
 Evidence X-RAY 2ipz D Reference
       Region 2ipz D 251-281 order
Seq 251-281 Hetero hexamer : Q9GZT6
 Evidence X-RAY 6h9m A Reference
       Region 6h9m A 251-279 order
       Region 6h9m A 280-281 disorder
 Evidence X-RAY 6h9m B Reference
       Region 6h9m B 251-279 order
       Region 6h9m B 280-281 disorder
 Evidence X-RAY 6h9m C Reference
       Region 6h9m C 251-279 order
       Region 6h9m C 280-281 disorder
Seq 252-279 Hetero trimer :
 Evidence X-RAY 7a4t B Reference
       Region 7a4t B 252-277 order
       Region 7a4t B 278-279 disorder
 Evidence X-RAY 7a4t C Reference
       Region 7a4t C 252-279 order
Seq 252-280 Hetero nonamer : P03377
 Evidence X-RAY 1fav A Reference
       Region 1fav A 252-252 disorder
       Region 1fav A 253-280 order
Seq 252-280 Hetero nonamer : P03377
 Evidence X-RAY 1env A Reference
       Region 1env A 252-280 order
Seq 252-280 Hetero hexamer : P12528
 Evidence X-RAY 2vnl A Reference
       Region 2vnl A 252-279 order
       Region 2vnl A 280-280 disorder
Seq 253-280 Hetero tetramer : P79114
 Evidence NMR 2n9b A Reference
       Region 2n9b A 253-280 order
 Evidence NMR 2n9b B Reference
       Region 2n9b B 253-280 order
Seq 253-281 Hetero tetramer : P08046
 Evidence X-RAY 1llm C Reference
       Region 1llm C 253-280 order
       Region 1llm C 281-281 disorder
 Evidence X-RAY 1llm D Reference
       Region 1llm D 253-278 order
       Region 1llm D 279-281 disorder
Seq 254-277 Hetero octamer : P58772
 Evidence X-RAY 2d3e A Reference
       Region 2d3e A 254-254 disorder
       Region 2d3e A 255-277 order
 Evidence X-RAY 2d3e B Reference
       Region 2d3e B 254-254 disorder
       Region 2d3e B 255-277 order
 Evidence X-RAY 2d3e C Reference
       Region 2d3e C 254-254 disorder
       Region 2d3e C 255-277 order
 Evidence X-RAY 2d3e D Reference
       Region 2d3e D 254-254 disorder
       Region 2d3e D 255-277 order
Seq 255-278 Hetero tetramer : P04692
 Evidence X-RAY 1kql A Reference
       Region 1kql A 255-278 order
 Evidence X-RAY 1kql B Reference
       Region 1kql B 255-278 order
Seq 256-280 Hetero hexamer : P12528
 Evidence X-RAY 2vky B Reference
       Region 2vky B 256-279 order
       Region 2vky B 280-280 disorder
Seq 258-276 Hetero hexamer : P03377
 Evidence X-RAY 3g9r A Reference
       Region 3g9r A 258-276 order
 Evidence X-RAY 3g9r B Reference
       Region 3g9r B 258-276 order
 Evidence X-RAY 3g9r C Reference
       Region 3g9r C 258-276 order
Seq 258-276 Hetero hexamer : P03377
 Evidence X-RAY 3g9r D Reference
       Region 3g9r D 258-276 order
 Evidence X-RAY 3g9r E Reference
       Region 3g9r E 258-276 order
 Evidence X-RAY 3g9r F Reference
       Region 3g9r F 258-276 order
Seq 259-278 Hetero tetramer : P58772
 Evidence X-RAY 2z5i C Reference
       Region 2z5i C 259-278 order
 Evidence X-RAY 2z5i D Reference
       Region 2z5i D 259-278 order
Seq 259-278 Hetero tetramer : P58772
 Evidence X-RAY 2z5h G Reference
       Region 2z5h G 259-278 order
 Evidence X-RAY 2z5h H Reference
       Region 2z5h H 259-278 order
Seq 259-278 Hetero tetramer : P58772
 Evidence X-RAY 2z5i A Reference
       Region 2z5i A 259-278 order
 Evidence X-RAY 2z5i B Reference
       Region 2z5i B 259-278 order
Seq 259-278 Hetero tetramer : P58772
 Evidence X-RAY 2z5i E Reference
       Region 2z5i E 259-278 order
 Evidence X-RAY 2z5i F Reference
       Region 2z5i F 259-278 order
Seq 259-278 Hetero tetramer : P58772
 Evidence X-RAY 2z5h C Reference
       Region 2z5h C 259-278 order
 Evidence X-RAY 2z5h D Reference
       Region 2z5h D 259-278 order
Seq 259-278 Hetero tetramer : P58772
 Evidence X-RAY 2z5i G Reference
       Region 2z5i G 259-278 order
 Evidence X-RAY 2z5i H Reference
       Region 2z5i H 259-278 order
Seq 259-278 Hetero tetramer : P58772
 Evidence X-RAY 2z5h E Reference
       Region 2z5h E 259-278 order
 Evidence X-RAY 2z5h F Reference
       Region 2z5h F 259-278 order
Seq 259-278 Hetero heptamer : P12620,P58772
 Evidence X-RAY 2z5h A Reference
       Region 2z5h A 259-278 order
 Evidence X-RAY 2z5h B Reference
       Region 2z5h B 259-278 order
 Evidence X-RAY 2z5h I Reference
       Region 2z5h I 267-277 order
       Region 2z5h I 278-278 disorder
Seq 264-280 Monomer :
 Evidence NMR 2ovn A Reference
       Region 2ovn A 264-280 order
       Region 2ovn A 280-280 high_rmsd
Seq 264-281 Hetero tetramer : P09493
 Evidence X-RAY 5kht A Reference
       Region 5kht A 264-281 order
 Evidence X-RAY 5kht C Reference
       Region 5kht C 264-281 order
Seq 264-281 Hetero hexamer : P04692
 Evidence NMR 2g9j A Reference
       Region 2g9j A 264-281 order
       Region 2g9j A 280-281 high_rmsd
 Evidence NMR 2g9j B Reference
       Region 2g9j B 264-281 order
       Region 2g9j B 280-281 high_rmsd
Seq 264-281 Hetero tetramer : P04692
 Evidence NMR 1tmz A Reference
       Region 1tmz A 264-281 order
 Evidence NMR 1tmz B Reference
       Region 1tmz B 264-281 order
Seq 264-281 Hetero tetramer : P04692
 Evidence NMR 1ihq A Reference
       Region 1ihq A 264-281 order
 Evidence NMR 1ihq B Reference
       Region 1ihq B 264-281 order
Seq 264-281 Hetero tetramer : P04692
 Evidence X-RAY 3azd A Reference
       Region 3azd A 264-279 order
       Region 3azd A 280-281 disorder
 Evidence X-RAY 3azd B Reference
       Region 3azd B 264-279 order
       Region 3azd B 280-281 disorder
Seq 264-281 Hetero tetramer : P09493
 Evidence X-RAY 5kht B Reference
       Region 5kht B 264-281 order
 Evidence X-RAY 5kht D Reference
       Region 5kht D 264-281 order
Seq 264-281 Hetero pentamer : P09493,Q6P5Q4
 Evidence NMR 6ut2 B Reference
       Region 6ut2 B 264-281 order
       Region 6ut2 B 280-281 high_rmsd
 Evidence NMR 6ut2 C Reference
       Region 6ut2 C 264-281 order
       Region 6ut2 C 280-281 high_rmsd
Seq 267-278 Hetero tetramer : P58772
 Evidence X-RAY 2z5i I Reference
       Region 2z5i I 267-278 order
 Evidence X-RAY 2z5i J Reference
       Region 2z5i J 267-278 order
SeqProS verified 101-134 Hetero dimer : P19659
       Region 2lpb B 101-134 order
       Region 1-134 disorder
Seqphosphorylation
    17-17 Phosphoserine
    165-165 Phosphothreonine; by PHO85
    218-218 Phosphoserine
 
Prediction
NeProc
Disorder 1-235,278-281
Order 236-277
ProS 7-22,42-51,60-66,97-126,226-235,278-281
AlphaFold
Disorder 1-3,8-88,100-118,127-127,141-163,166-197,280-281
Order 4-7,89-99,119-126,128-140,164-165,198-279
SEG 178-192
Function
Function in SwissProt
Master transcriptional regulator that mediates the response to amino acid starvation (PubMed:11390663, PubMed:29628310). Binds variations of the DNA sequence 5'-ATGA[CG]TCAT-3' in canonical nucleosome-depleted 5'-positioned promoters, and also within coding sequences and 3' non-coding regions (PubMed:29628310, PubMed:11390663, PubMed:1473154, PubMed:2277632, PubMed:1939099, PubMed:7664107, PubMed:2204805, PubMed:3678204, PubMed:3532321, PubMed:3530496). During nutrient starvation (low or poor amino acid, carbon or purine sources), it activates genes required for amino acid biosynthesis and transport, autophagy, cofactor biosynthesis and transport, mitochondrial transport, and additional downstream transcription factors (PubMed:11390663, PubMed:29628310, PubMed:8336737, PubMed:1939099, PubMed:10733573, PubMed:7862116). Activates transcription by recruiting multiple coactivators, including the mediator complex, the SAGA complex, and the SWI/SNF complex, to enable assembly of the pre-initiation complex at core promoters (PubMed:19940160, PubMed:9488488, PubMed:10549298).