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IID50425
 UniprotP07260
ProteinEukaryotic translation initiation factor 4E
GeneCDC33
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
213
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-35
 Evidence NMR The N-terminal 35 residues are unstructured as indicated by the absence of long-range NOEs and by 15N relaxation studies (data not shown). Reference
       Region 1-35 disorder
Seq 1-213 Hetero dimer : IID50441Complex
 Evidence NMR 1rf8 A Reference
       Region 1rf8 A 1-213 order
       Region 1rf8 A 1-21 high_rmsd
       Region 1rf8 A 54-54 high_rmsd
       Region 1rf8 A 190-190 high_rmsd
       Region 1rf8 A 203-208 high_rmsd
Seq 1-213 Monomer :
 Evidence NMR 1ap8 A Reference
       Region 1ap8 A 1-213 order
       Region 1ap8 A 1-35 high_rmsd
       Region 1ap8 A 52-54 high_rmsd
       Region 1ap8 A 207-207 high_rmsd
Seq 25-213 Hetero tetramer : P36041
 Evidence X-RAY 6fc1 A Reference
       Region 6fc1 A 25-30 order
       Region 6fc1 A 31-34 disorder
       Region 6fc1 A 35-200 order
       Region 6fc1 A 201-207 disorder
       Region 6fc1 A 208-213 order
 Evidence X-RAY 6fc1 C Reference
       Region 6fc1 C 25-28 order
       Region 6fc1 C 29-32 disorder
       Region 6fc1 C 33-200 order
       Region 6fc1 C 201-207 disorder
       Region 6fc1 C 208-213 order
Seq 35-213 Hetero tetramer : P36041
 Evidence X-RAY 6fc2 A Reference
       Region 6fc2 A 35-201 order
       Region 6fc2 A 202-206 disorder
       Region 6fc2 A 207-213 order
 Evidence X-RAY 6fc2 C Reference
       Region 6fc2 C 35-201 order
       Region 6fc2 C 202-203 disorder
       Region 6fc2 C 204-213 order
Seq 35-213 Hetero dimer : P12962
 Evidence X-RAY 6fc3 A Reference
       Region 6fc3 A 35-103 order
       Region 6fc3 A 104-106 disorder
       Region 6fc3 A 107-144 order
       Region 6fc3 A 145-147 disorder
       Region 6fc3 A 148-213 order
SeqProS verified 22-35 The residues with high_rmsd are excluded from the ProS. Hetero dimer : IID50441Complex
       Region 1rf8 A 1-213 order
       Region 1-35 disorder
SeqProS verified 25-30 Hetero tetramer : P36041
       Region 6fc1 A 25-30 order
       Region 6fc1 C 25-28 order
       Region 1-35 disorder
Seqphosphorylation
    30-30 Phosphoserine
    28-28 Phosphoserine
    22-22 Phosphothreonine
    15-15 Phosphoserine; by CK2
    2-2 Phosphoserine; by CK2
 
Prediction
NeProc
Disorder 1-29,206-213
Order 30-205
ProS 25-29,206-213
AlphaFold
Disorder 1-1,10-20,122-124,202-203
Order 2-9,21-121,125-201,204-213
Function
Function in SwissProt
Recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.