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IID50430
 UniprotP19490
ProteinGlutamate receptor 1
GeneGria1
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
907
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 22-392 Homo tetramer :
 Evidence X-RAY 3saj A Reference
       Region 3saj A 22-277 order
       Region 3saj A 278-283 disorder
       Region 3saj A 284-392 order
 Evidence X-RAY 3saj B Reference
       Region 3saj B 22-277 order
       Region 3saj B 278-283 disorder
       Region 3saj B 284-391 order
       Region 3saj B 392-392 disorder
 Evidence X-RAY 3saj C Reference
       Region 3saj C 22-391 order
       Region 3saj C 392-392 disorder
 Evidence X-RAY 3saj D Reference
       Region 3saj D 22-277 order
       Region 3saj D 278-283 disorder
       Region 3saj D 284-391 order
       Region 3saj D 392-392 disorder
Seq 890-907 Hetero trimer : Q62696
 Evidence X-RAY 2aww C Reference
       Region 2aww C 890-903 disorder
       Region 2aww C 904-907 order
Seq 890-907 Hetero dimer : Q62696
 Evidence X-RAY 2g2l C Reference
       Region 2g2l C 890-903 disorder
       Region 2g2l C 904-907 order
 Evidence X-RAY 2g2l D Reference
       Region 2g2l D 890-906 disorder
       Region 2g2l D 907-907 order
SeqProS predicted 904-907 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : Q62696
       Region 2g2l C 904-907 order
       Region 2g2l D 907-907 order
SeqProS predicted 904-907 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero trimer : Q62696
       Region 2aww C 904-907 order
Seqphosphorylation
    645-645 Phosphoserine
    710-710 Phosphoserine; by PKC
    849-849 Phosphoserine; by PKC
    863-863 Phosphoserine; by PKC and PKA
 
Prediction
NeProc
Disorder 1-13,786-801,855-907
Order 14-785,802-854
ProS 1-13,786-790,798-801,855-858,874-907
AlphaFold
Disorder 1-20,274-284,319-320,392-406,523-527,564-584,640-643,788-802,804-805,838-907
Order 21-273,285-318,321-391,407-522,528-563,585-639,644-787,803-803,806-837
SEG 550-561 ,783-799 ,863-874
Function
Function in SwissProt
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.