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IID50431
 UniprotP19538
ProteinTranscriptional activator cubitus interruptus
Geneci
OrganismDrosophila melanogaster
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1397
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1356-1367 Hetero dimer : IID00529Complex
 Evidence X-RAY 3hqm C Reference
       Region 3hqm C 1356-1359 disorder
       Region 3hqm C 1360-1366 order
       Region 3hqm C 1367-1367 disorder
 Evidence X-RAY 3hqm D Reference
       Region 3hqm D 1356-1359 disorder
       Region 3hqm D 1360-1366 order
       Region 3hqm D 1367-1367 disorder
SeqProS predicted 1360-1366 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : IID00529Complex
       Region 3hqm C 1360-1366 order
       Region 3hqm D 1360-1366 order
 
Prediction
NeProc
Disorder 9-446,563-570,601-1386,1394-1397
Order 1-8,447-562,571-600,1387-1393
ProS 9-21,45-50,65-70,110-123,142-147,213-245,437-441,563-570,601-620,659-665,688-716,742-745,768-781,833-853,878-890,909-926,988-1013,1019-1027,1074-1098,1223-1229,1319-1337,1370-1386,1394-1397
AlphaFold
Disorder 1-17,19-19,26-449,610-714,717-717,719-772,775-775,778-1320,1336-1383,1385-1385
Order 18-18,20-25,450-609,715-716,718-718,773-774,776-777,1321-1335,1384-1384,1386-1397
Pfam Hmmer
547->572 517-541 578->603
SEG 21-32 ,46-61 ,88-101 ,158-167 ,172-179 ,245-261 ,657-670 ,695-717 ,849-863 ,939-947
Function
Function in SwissProt
Has a dual function as a transcriptional activator and a repressor of the hedgehog (Hh) pathway. The full-length ci form (ciFL), acts as an activator (ciA) while ciR, its C-terminally truncated form, acts as a repressor. Involved in segment polarity. Required for the normal development of the posterior half of each embryonic segment. Engrailed protein directly represses ci expression in posterior compartment cells. Essential component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required to activate Cad99C-dependent endosome formation, norpA-dependent Ca2+ mobilization and p38 MAPK, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).