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IID50437
 UniprotP35561
ProteinInward rectifier potassium channel 2
GeneKcnj2
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
428
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 41-63,188-428 homo :
 Evidence X-RAY 1u4f A Reference
       Region 1u4f A 41-44 disorder
       Region 1u4f A 45-63 order
       Region 1u4f A 188-365 order
       Region 1u4f A 366-428 disorder
 Evidence X-RAY 1u4f B Reference
       Region 1u4f B 41-44 disorder
       Region 1u4f B 45-63 order
       Region 1u4f B 188-189 disorder
       Region 1u4f B 190-365 order
       Region 1u4f B 366-428 disorder
 Evidence X-RAY 1u4f C Reference
       Region 1u4f C 41-44 disorder
       Region 1u4f C 45-63 order
       Region 1u4f C 188-189 disorder
       Region 1u4f C 190-365 order
       Region 1u4f C 366-428 disorder
 Evidence X-RAY 1u4f D Reference
       Region 1u4f D 41-44 disorder
       Region 1u4f D 45-63 order
       Region 1u4f D 188-188 order
       Region 1u4f D 189-191 disorder
       Region 1u4f D 192-368 order
       Region 1u4f D 369-428 disorder
Seq 44-64,189-371 Homo :
 Evidence X-RAY 2gix A Reference
       Region 2gix A 44-64 order
       Region 2gix A 189-370 order
       Region 2gix A 371-371 disorder
 Evidence X-RAY 2gix B Reference
       Region 2gix B 44-64 order
       Region 2gix B 189-365 order
       Region 2gix B 366-371 disorder
 Evidence X-RAY 2gix C Reference
       Region 2gix C 44-64 order
       Region 2gix C 189-370 order
       Region 2gix C 371-371 disorder
 Evidence X-RAY 2gix D Reference
       Region 2gix D 44-64 order
       Region 2gix D 189-369 order
       Region 2gix D 370-371 disorder
 
Prediction
NeProc
Disorder 1-40,365-428
Order 41-364
ProS 4-12,17-21,28-35,415-428
AlphaFold
Disorder 1-44,387-428
Order 45-386
Function
Function in SwissProt
Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.