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IID50438
 UniprotP36142
ProteinVacuole membrane protein HFL1
GeneHFL1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
418
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 368-389 Hetero tetradecamer : P38182
 Evidence X-RAY 6aag A Reference
       Region 6aag A 368-389 order
 Evidence X-RAY 6aag B Reference
       Region 6aag B 368-389 order
 Evidence X-RAY 6aag C Reference
       Region 6aag C 368-389 order
 Evidence X-RAY 6aag D Reference
       Region 6aag D 368-389 order
 Evidence X-RAY 6aag E Reference
       Region 6aag E 368-377 order
       Region 6aag E 378-378 disorder
       Region 6aag E 379-389 order
 Evidence X-RAY 6aag F Reference
       Region 6aag F 368-389 order
 Evidence X-RAY 6aag G Reference
       Region 6aag G 368-389 order
SeqProS predicted 368-383 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetradecamer : P38182
       Region 6aag A 368-389 order
       Region 6aag B 368-389 order
       Region 6aag C 368-389 order
       Region 6aag D 368-389 order
       Region 6aag E 368-377 order
       Region 6aag E 379-389 order
       Region 6aag F 368-389 order
       Region 6aag G 368-389 order
 
Prediction
NeProc
Disorder 1-6,319-418
Order 7-275,280-318
ProS 1-6,335-371,381-418
AlphaFold
Disorder 1-6,111-114,116-122,124-124,232-239,322-322,325-326,328-329,354-383,393-394,417-418
Order 7-110,115-115,123-123,125-231,240-321,323-324,327-327,330-353,384-392,395-416
SEG 87-96
Function
Function in SwissProt
Vacuole membrane protein that recruits ATG8 to facilitate the degradation of vacuolar integral membrane proteins during early-stationary vacuole turnover (EVT) when cells enter stationary phase.