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IID50442
UniprotP40344
ProteinAutophagy-related protein 3
GeneATG3
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
310
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-310 Hetero tetramer : P38862
 Evidence X-RAY 4gsl C Reference
       Region 4gsl C 1-20 disorder
       Region 4gsl C 21-83 order
       Region 4gsl C 84-128 disorder
       Region 4gsl C 129-142 order
       Region 4gsl C 143-162 disorder
       Region 4gsl C 163-246 order
       Region 4gsl C 247-280 disorder
       Region 4gsl C 281-305 order
       Region 4gsl C 306-310 disorder
 Evidence X-RAY 4gsl D Reference
       Region 4gsl D 1-20 disorder
       Region 4gsl D 21-83 order
       Region 4gsl D 84-131 disorder
       Region 4gsl D 132-141 order
       Region 4gsl D 142-163 disorder
       Region 4gsl D 164-247 order
       Region 4gsl D 248-281 disorder
       Region 4gsl D 282-304 order
       Region 4gsl D 305-310 disorder
Seq 1-310 Monomer :
 Evidence X-RAY 2dyt A Reference
       Region 2dyt A 1-20 disorder
       Region 2dyt A 21-83 order
       Region 2dyt A 84-128 disorder
       Region 2dyt A 129-142 order
       Region 2dyt A 143-162 disorder
       Region 2dyt A 163-270 order
       Region 2dyt A 271-278 disorder
       Region 2dyt A 279-306 order
       Region 2dyt A 307-310 disorder
 Evidence X-RAY 6ojj A Reference
       Region 6ojj A 19-77 order
       Region 6ojj A 78-85 disorder
       Region 6ojj A 160-165 disorder
       Region 6ojj A 166-257 order
       Region 6ojj A 258-276 disorder
       Region 6ojj A 277-308 order
       Region 6ojj A 309-310 disorder
Seqdisorder 84-162
 Evidence NMR Reference
       Region 84-162 disorder
Seq 128-144 Hetero dimer : P38862
 Evidence X-RAY 3t7g C Reference
       Region 3t7g C 128-130 disorder
       Region 3t7g C 131-142 order
       Region 3t7g C 143-144 disorder
 Evidence X-RAY 3t7g D Reference
       Region 3t7g D 128-132 disorder
       Region 3t7g D 133-142 order
       Region 3t7g D 143-144 disorder
SeqProS verified 129-142 Hetero tetramer : P38862
       Region 4gsl C 129-142 order
       Region 4gsl D 132-141 order
       Region 84-162 disorder
SeqProS verified 129-142 Hetero dimer : P38862
       Region 3t7g C 131-142 order
       Region 3t7g D 133-142 order
       Region 84-162 disorder
Seqacetylation
    48-48 N6-acetyllysine; by ESA1
    19-19 N6-acetyllysine; by ESA1
 
Prediction
NeProc
Disorder 99-128,157-160,250-279
Order 1-98,129-156,161-249,280-310
ProS 99-128,157-160
AlphaFold
Disorder 1-14,84-164,265-278,305-310
Order 15-83,165-264,279-304
SEG 140-152 ,243-265
Function
Function in SwissProt
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.