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IID50445
 UniprotP49024
ProteinPaxillin
GenePXN
OrganismGallus gallus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
559
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 133-290
 Evidence NMR Reference
       Region 133-290 disorder
Seq 139-162 Hetero trimer : Q14289
 Evidence X-RAY 4r32 B Reference
       Region 4r32 B 139-142 disorder
       Region 4r32 B 143-153 order
       Region 4r32 B 154-162 disorder
 Evidence X-RAY 4r32 C Reference
       Region 4r32 C 139-139 disorder
       Region 4r32 C 140-154 order
       Region 4r32 C 155-162 disorder
Seq 140-161 Hetero dimer : Q00944
 Evidence NMR 2l6g A Reference
       Region 2l6g A 140-161 order
       Region 2l6g A 140-140 high_rmsd
Seq 140-161,262-275 Hetero trimer : Q00944
 Evidence NMR 2l6f A Reference
       Region 2l6f A 140-161 order
       Region 2l6f A 140-140 high_rmsd
       Region 2l6f A 262-275 order
Seq 262-278
 Evidence X-RAY 3u3f G Reference
       Region 3u3f G 262-273 order
       Region 3u3f G 274-278 disorder
Seq 262-278 Hetero trimer : Q14289
 Evidence X-RAY 3u3f E Reference
       Region 3u3f E 262-274 order
       Region 3u3f E 275-278 disorder
 Evidence X-RAY 3u3f I Reference
       Region 3u3f I 262-265 disorder
       Region 3u3f I 266-275 order
       Region 3u3f I 276-278 disorder
 Evidence X-RAY 3u3f F Reference
       Region 3u3f F 262-274 order
       Region 3u3f F 275-278 disorder
Seq 262-278
 Evidence X-RAY 3u3f H Reference
       Region 3u3f H 262-275 order
       Region 3u3f H 276-278 disorder
Seq 262-278
 Evidence X-RAY 3u3f J Reference
       Region 3u3f J 262-265 disorder
       Region 3u3f J 266-275 order
       Region 3u3f J 276-278 disorder
Seq 263-276 Hetero dimer : Q00944
 Evidence NMR 2l6h A Reference
       Region 2l6h A 263-276 order
SeqProS verified 140-154 LD motif 2 Hetero trimer : Q14289
       Region 4r32 B 143-153 order
       Region 4r32 C 140-154 order
       Region 133-290 disorder
SeqProS verified 262-275 LD motif 4 Hetero trimer : Q14289
       Region 3u3f E 262-274 order
       Region 3u3f F 262-274 order
       Region 3u3f I 266-275 order
       Region 133-290 disorder
Seqphosphorylation
    118-118 Phosphotyrosine; by FAK1
    31-31 Phosphotyrosine
 
Prediction
NeProc
Disorder 1-317
Order 318-559
ProS 1-25,57-62,140-155,174-177,217-224,277-284,294-317
AlphaFold
Disorder 1-4,7-142,155-217,221-221,227-263,274-274,276-301,316-320
Order 5-6,143-154,218-220,222-226,264-273,275-275,302-315,321-559
Pfam Hmmer
326->382 44-254 385->441
SEG 2-11 ,45-53 ,79-98 ,138-153 ,187-190 ,216-232 ,281-301
Function
Function in SwissProt
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of v-CRK.