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IID50452
 UniprotQ3U5C8
ProteinRho guanine nucleotide exchange factor 16
GeneArhgef16
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
713
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 152-163 Hetero tetramer : Q9WVQ1
 Evidence X-RAY 7ykf B Reference
       Region 7ykf B 152-162 order
       Region 7ykf B 163-163 disorder
 Evidence X-RAY 7ykf D Reference
       Region 7ykf D 152-163 order
Seq 209-241,253-713 Homo dimer :
 Evidence X-RAY 7csp A Reference
       Region 7csp A 209-213 disorder
       Region 7csp A 214-230 order
       Region 7csp A 231-241 disorder
       Region 7csp A 253-263 disorder
       Region 7csp A 264-571 order
       Region 7csp A 572-579 disorder
       Region 7csp A 580-709 order
       Region 7csp A 710-713 disorder
 Evidence X-RAY 7csp B Reference
       Region 7csp B 209-216 disorder
       Region 7csp B 217-231 order
       Region 7csp B 232-241 disorder
       Region 7csp B 253-254 disorder
       Region 7csp B 255-516 order
       Region 7csp B 517-527 disorder
       Region 7csp B 528-571 order
       Region 7csp B 572-582 disorder
       Region 7csp B 583-709 order
       Region 7csp B 710-713 disorder
Seq 261-713 Homo trimer :
 Evidence X-RAY 7csr A Reference
       Region 7csr A 261-263 disorder
       Region 7csr A 264-568 order
       Region 7csr A 569-581 disorder
       Region 7csr A 582-623 order
       Region 7csr A 624-631 disorder
       Region 7csr A 632-709 order
       Region 7csr A 710-713 disorder
 Evidence X-RAY 7csr B Reference
       Region 7csr B 261-263 disorder
       Region 7csr B 264-570 order
       Region 7csr B 571-580 disorder
       Region 7csr B 581-623 order
       Region 7csr B 624-633 disorder
       Region 7csr B 634-701 order
       Region 7csr B 702-713 disorder
 Evidence X-RAY 7csr C Reference
       Region 7csr C 261-263 disorder
       Region 7csr C 264-575 order
       Region 7csr C 576-580 disorder
       Region 7csr C 581-623 order
       Region 7csr C 624-632 disorder
       Region 7csr C 633-709 order
       Region 7csr C 710-713 disorder
Seq 261-713 Homo tetramer :
 Evidence X-RAY 7cso A Reference
       Region 7cso A 261-263 disorder
       Region 7cso A 264-572 order
       Region 7cso A 573-579 disorder
       Region 7cso A 580-623 order
       Region 7cso A 624-630 disorder
       Region 7cso A 631-709 order
       Region 7cso A 710-713 disorder
 Evidence X-RAY 7cso B Reference
       Region 7cso B 261-263 disorder
       Region 7cso B 264-573 order
       Region 7cso B 574-580 disorder
       Region 7cso B 581-624 order
       Region 7cso B 625-630 disorder
       Region 7cso B 631-709 order
       Region 7cso B 710-713 disorder
 Evidence X-RAY 7cso C Reference
       Region 7cso C 261-263 disorder
       Region 7cso C 264-572 order
       Region 7cso C 573-578 disorder
       Region 7cso C 579-624 order
       Region 7cso C 625-629 disorder
       Region 7cso C 630-711 order
       Region 7cso C 712-713 disorder
 Evidence X-RAY 7cso D Reference
       Region 7cso D 261-263 disorder
       Region 7cso D 264-572 order
       Region 7cso D 573-580 disorder
       Region 7cso D 581-625 order
       Region 7cso D 626-629 disorder
       Region 7cso D 630-709 order
       Region 7cso D 710-713 disorder
SeqProS predicted 152-163 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : Q9WVQ1
       Region 7ykf B 152-162 order
       Region 7ykf D 152-163 order
 
Prediction
NeProc
Disorder 1-264,502-507,512-527,569-581
Order 265-501,508-511,528-568,582-618,626-713
ProS 4-30,72-96,134-138,159-161,204-236,502-507,512-516
AlphaFold
Disorder 1-78,80-82,84-211,225-264,517-527,569-582,626-633,707-713
Order 79-79,83-83,212-224,265-516,528-568,583-625,634-706
Pfam Hmmer
506->624 292-471 636->691
SEG 51-72 ,566-582
Function
Function in SwissProt
Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 (By similarity).