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IID50455
 UniprotQ60610
ProteinRho guanine nucleotide exchange factor TIAM1
GeneTiam1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1591
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 429-702 Monomer :
 Evidence X-RAY 3a8n A Reference
       Region 3a8n A 429-432 disorder
       Region 3a8n A 433-480 order
       Region 3a8n A 481-488 disorder
       Region 3a8n A 489-670 order
       Region 3a8n A 671-702 disorder
Seq 1033-1406 Hetero dimer : IID00312Complex
 Evidence X-RAY 1foe A Reference
       Region 1foe A 1033-1033 disorder
       Region 1foe A 1034-1401 order
       Region 1foe A 1402-1406 disorder
 Evidence X-RAY 1foe C Reference
       Region 1foe C 1033-1035 disorder
       Region 1foe C 1036-1401 order
       Region 1foe C 1402-1406 disorder
 Evidence X-RAY 1foe E Reference
       Region 1foe E 1033-1034 disorder
       Region 1foe E 1035-1401 order
       Region 1foe E 1402-1406 disorder
 Evidence X-RAY 1foe G Reference
       Region 1foe G 1033-1034 disorder
       Region 1foe G 1035-1401 order
       Region 1foe G 1402-1406 disorder
Seq 1541-1559 Hetero tetramer : Q9UQM7
 Evidence X-RAY 7uiq C Reference
       Region 7uiq C 1541-1559 order
 Evidence X-RAY 7uiq D Reference
       Region 7uiq D 1541-1544 disorder
       Region 7uiq D 1545-1559 order
 Evidence X-RAY 7uir C Reference
       Region 7uir C 1541-1559 order
 Evidence X-RAY 7uir D Reference
       Region 7uir D 1541-1543 disorder
       Region 7uir D 1544-1559 order
SeqProS predicted 1541-1559 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero tetramer : Q9UQM7
       Region 7uiq C 1541-1559 order
       Region 7uiq D 1545-1559 order
       Region 7uir C 1541-1559 order
       Region 7uir D 1544-1559 order
Seqphosphorylation
    1323-1323 Phosphotyrosine
    1519-1519 Phosphoserine
    695-695 Phosphoserine
    829-829 Phosphotyrosine; by NTRK2
    231-231 Phosphoserine
    356-356 Phosphoserine
    358-358 Phosphoserine
 
Prediction
NeProc
Disorder 1-97,107-431,661-754,934-1035,1308-1323,1400-1591
Order 98-106,432-660,755-933,1036-1307,1324-1399
ProS 1-36,47-97,107-110,128-132,134-145,150-155,175-200,207-214,230-238,249-269,280-340,376-401,421-431,661-677,694-701,711-721,729-737,749-754,934-971,979-994,1000-1013,1411-1425,1455-1463,1500-1511,1522-1535,1571-1591
AlphaFold
Disorder 1-432,459-459,479-488,557-557,671-765,814-815,851-856,867-869,929-941,943-1034,1253-1256,1285-1285,1307-1326,1344-1351,1403-1591
Order 433-458,460-478,489-556,558-670,766-813,816-850,857-866,870-928,942-942,1035-1252,1257-1284,1286-1306,1327-1343,1352-1402
Pfam Hmmer
765->832 434-547 845->925
SEG 52-67 ,178-189 ,367-377 ,573-586 ,683-695 ,1013-1028 ,1445-1454
Function
Function in SwissProt
Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration.
Biological Process
Diagram with PDB data
Tiam1/CAMK2ACocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and Tiam1 in complex with ATP