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IID50459
 UniprotQ811U3
ProteinELKS/Rab6-interacting/CAST family member 1
GeneErc1
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
948
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 849-922 Hetero tetramer : P61294
 Evidence X-RAY 8ij9 C Reference
       Region 8ij9 C 849-919 order
       Region 8ij9 C 920-922 disorder
 Evidence X-RAY 8ij9 D Reference
       Region 8ij9 D 849-881 order
       Region 8ij9 D 882-885 disorder
       Region 8ij9 D 886-919 order
       Region 8ij9 D 920-922 disorder
Seq 939-948 Hetero dimer : Q9JIR4
 Evidence NMR 1zub B Reference
       Region 1zub B 939-942 disorder
       Region 1zub B 943-948 order
SeqProS predicted 943-948 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero dimer : Q9JIR4
       Region 1zub B 943-948 order
Seqphosphorylation
    937-937 Phosphoserine
    796-796 Phosphoserine
    94-94 Phosphoserine
    75-75 Phosphoserine
    55-55 Phosphoserine
    38-38 Phosphothreonine
    37-37 Phosphoserine
    21-21 Phosphoserine
    17-17 Phosphoserine
Seqacetylation
    10-10 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-143,179-207,250-263,316-335,371-376,426-439,524-530,654-667,862-868,918-948
Order 144-178,208-249,264-315,336-370,377-425,440-523,531-653,668-861,869-917
ProS 1-22,28-37,47-77,84-128,179-207,250-250,260-263,316-319,328-335,371-376,426-439,524-530,654-667,862-868,918-923,941-948
AlphaFold
Disorder 1-139,190-190,246-266,317-328,368-377,406-423,682-682,685-707,709-709,712-712,754-802,919-948
Order 140-189,191-245,267-316,329-367,378-405,424-681,683-684,708-708,710-711,713-753,803-918
SEG 13-51 ,417-422 ,579-598 ,602-618 ,738-750 ,787-810
Function
Function in SwissProt
Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex (By similarity). May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.