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IID50461
 UniprotQ8JGS1
ProteinSCL-interrupting locus protein homolog
Genestil
OrganismDanio rerio
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1263
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 399-450 Hetero dimer : E7FCY1
 Evidence X-RAY 4bxr C Reference
       Region 4bxr C 408-413 disorder
       Region 4bxr C 414-425 order
       Region 4bxr C 426-428 disorder
 Evidence X-RAY 4bxr D Reference
       Region 4bxr D 408-413 disorder
       Region 4bxr D 414-427 order
       Region 4bxr D 428-428 disorder
 Evidence X-RAY 4ld3 B Reference
       Region 4ld3 B 399-412 disorder
       Region 4ld3 B 413-428 order
       Region 4ld3 B 429-450 disorder
 Evidence X-RAY 4lzf B Reference
       Region 4lzf B 414-425 order
       Region 4lzf B 426-428 disorder
SeqProS predicted 413-428 This region is predicted to be disordered by NeProc and AlphaFold (pLDDT < 68.5). Hetero dimer : E7FCY1
       Region 4ld3 B 413-428 order
       Region 4bxr C 414-425 order
       Region 4bxr D 414-427 order
       Region 4lzf B 414-425 order
 
Prediction
NeProc
Disorder 1-35,362-1017,1071-1170,1176-1263
Order 36-329,335-352,357-361,1018-1042,1050-1070,1171-1175
ProS 1-21,362-382,414-419,432-437,443-448,622-628,747-753,804-807,815-819,920-934,954-964,989-1007,1013-1017,1071-1079,1098-1131,1176-1183,1195-1201,1208-1227,1245-1263
AlphaFold
Disorder 1-37,123-125,147-150,236-240,330-333,356-357,384-747,749-749,774-922,929-991,1001-1058,1061-1061,1077-1121,1127-1263
Order 38-122,126-146,151-235,241-329,334-355,358-383,748-748,750-773,923-928,992-1000,1059-1060,1062-1076,1122-1126
SEG 170-182 ,385-396 ,493-506 ,533-554 ,589-602 ,692-705 ,756-775 ,902-907 ,1068-1090 ,1128-1139
Function
Function in SwissProt
Plays an essential role in early embryonic development (PubMed:12006978). Plays an important role in the regulation of centriole duplication and directional cell motility (By similarity).