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IID50465
 UniprotQ8VDU0
ProteinG-protein-signaling modulator 2
GeneGpsm2
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
679
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 22-357 Hetero dimer : Q5SYB0
 Evidence X-RAY 4g2v A Reference
       Region 4g2v A 22-159 order
       Region 4g2v A 160-170 disorder
       Region 4g2v A 171-351 order
       Region 4g2v A 352-357 disorder
Seq 22-357 Hetero dimer : Q14980
 Evidence X-RAY 3ro2 A Reference
       Region 3ro2 A 22-165 order
       Region 3ro2 A 166-169 disorder
       Region 3ro2 A 170-351 order
       Region 3ro2 A 352-357 disorder
Seq 22-357 Hetero dimer : Q9P202
 Evidence X-RAY 7ep7 A Reference
       Region 7ep7 A 22-162 order
       Region 7ep7 A 163-169 disorder
       Region 7ep7 A 170-351 order
       Region 7ep7 A 352-357 disorder
Seq 96-357,593-651 Homo dimer :
 Evidence X-RAY 4jhr A Reference
       Region 4jhr A 96-116 disorder
       Region 4jhr A 117-158 order
       Region 4jhr A 159-171 disorder
       Region 4jhr A 172-357 order
       Region 4jhr A 593-648 order
       Region 4jhr A 649-651 disorder
 Evidence X-RAY 4jhr B Reference
       Region 4jhr B 96-116 disorder
       Region 4jhr B 117-159 order
       Region 4jhr B 160-171 disorder
       Region 4jhr B 172-357 order
       Region 4jhr B 593-648 order
       Region 4jhr B 649-651 disorder
Seq 198-357 Hetero dimer : Q3HNM7
 Evidence X-RAY 3ro3 A Reference
       Region 3ro3 A 198-355 order
       Region 3ro3 A 356-357 disorder
Seq 594-618 Hetero dimer : P08754
 Evidence X-RAY 4g5s E Reference
       Region 4g5s E 594-595 disorder
       Region 4g5s E 596-617 order
       Region 4g5s E 618-618 disorder
 Evidence X-RAY 4g5s F Reference
       Region 4g5s F 594-595 disorder
       Region 4g5s F 596-617 order
       Region 4g5s F 618-618 disorder
 Evidence X-RAY 4g5s G Reference
       Region 4g5s G 594-595 disorder
       Region 4g5s G 596-605 order
       Region 4g5s G 606-606 disorder
       Region 4g5s G 607-617 order
       Region 4g5s G 618-618 disorder
 Evidence X-RAY 4g5s Z Reference
       Region 4g5s Z 594-597 disorder
       Region 4g5s Z 598-606 order
       Region 4g5s Z 607-607 disorder
       Region 4g5s Z 608-617 order
       Region 4g5s Z 618-618 disorder
Seq 628-652 Hetero dimer : IID00608Complex
 Evidence X-RAY 4g5q E Reference
       Region 4g5q E 628-629 disorder
       Region 4g5q E 630-650 order
       Region 4g5q E 651-652 disorder
 Evidence X-RAY 4g5q F Reference
       Region 4g5q F 628-628 disorder
       Region 4g5q F 629-650 order
       Region 4g5q F 651-652 disorder
 Evidence X-RAY 4g5q G Reference
       Region 4g5q G 628-628 disorder
       Region 4g5q G 629-652 order
 Evidence X-RAY 4g5q H Reference
       Region 4g5q H 628-628 disorder
       Region 4g5q H 629-650 order
       Region 4g5q H 651-652 disorder
Seq 628-653 Hetero dimer : P08754
 Evidence X-RAY 4g5o E Reference
       Region 4g5o E 628-628 disorder
       Region 4g5o E 629-650 order
       Region 4g5o E 651-653 disorder
 Evidence X-RAY 4g5o F Reference
       Region 4g5o F 628-628 disorder
       Region 4g5o F 629-650 order
       Region 4g5o F 651-653 disorder
 Evidence X-RAY 4g5o G Reference
       Region 4g5o G 628-628 disorder
       Region 4g5o G 629-650 order
       Region 4g5o G 651-653 disorder
 Evidence X-RAY 4g5o H Reference
       Region 4g5o H 628-628 disorder
       Region 4g5o H 629-651 order
       Region 4g5o H 652-653 disorder
 Evidence X-RAY 4g5r E Reference
       Region 4g5r E 628-629 disorder
       Region 4g5r E 630-650 order
       Region 4g5r E 651-652 disorder
 Evidence X-RAY 4g5r F Reference
       Region 4g5r F 628-629 disorder
       Region 4g5r F 630-651 order
       Region 4g5r F 652-652 disorder
 Evidence X-RAY 4g5r G Reference
       Region 4g5r G 628-629 disorder
       Region 4g5r G 630-651 order
       Region 4g5r G 652-652 disorder
 Evidence X-RAY 4g5r Z Reference
       Region 4g5r Z 628-629 disorder
       Region 4g5r Z 630-650 order
       Region 4g5r Z 651-652 disorder
SeqProS predicted 593-648 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc; auto-inhibited conformation Homo dimer :
       Region 4jhr A 593-648 order
       Region 4jhr B 593-648 order
SeqProS predicted 596-617 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero dimer : P08754
       Region 4g5s E 596-617 order
       Region 4g5s F 596-617 order
       Region 4g5s G 596-605 order
       Region 4g5s G 607-617 order
       Region 4g5s Z 598-606 order
       Region 4g5s Z 608-617 order
SeqProS predicted 629-651 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero dimer : P08754
       Region 4g5r E 630-650 order
       Region 4g5r F 630-651 order
       Region 4g5r G 630-651 order
       Region 4g5r Z 630-650 order
       Region 4g5o E 629-650 order
       Region 4g5o F 629-650 order
       Region 4g5o G 629-650 order
       Region 4g5o H 629-651 order
SeqProS predicted 629-652 This region is predicted to be disordered by AlphaFold (pLDDT <68.5) and NeProc. Hetero dimer : IID00608Complex
       Region 4g5q E 630-650 order
       Region 4g5q F 629-650 order
       Region 4g5q G 629-652 order
       Region 4g5q H 629-650 order
Seqphosphorylation
    564-564 Phosphoserine
    408-408 Phosphoserine
    484-484 Phosphoserine
    487-487 Phosphothreonine
    540-540 Phosphoserine
 
Prediction
NeProc
Disorder 165-169,438-679
Order 1-164,170-437
ProS 165-169,438-474,487-514,542-576,588-616,624-652,662-679
AlphaFold
Disorder 1-20,160-170,377-679
Order 21-159,171-376
Pfam Hmmer
242->275 102-135 282->315
SEG 518-527
Function
Function in SwissProt
Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity). Plays a role in metaphase spindle orientation (By similarity). Plays an important role in asymmetric cell divisions (PubMed:12571286, PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (PubMed:22952234).