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IID50468
 UniprotQ99ML1
ProteinBcl-2-binding component 3
GeneBbc3
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
193
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 128-161
 Evidence CD From the CD spectrum, it can be calculated that the PUMA peptide has approx. 20% residual helicity in the unbound state. Reference
       Region 128-161 disorder
Seq 130-155 Hetero dimer : P97287
 Evidence NMR 2roc B Reference
       Region 2roc B 130-155 order
Seq 130-155 Hetero dimer : Q07440
 Evidence X-RAY 2vof B Reference
       Region 2vof B 130-130 disorder
       Region 2vof B 131-153 order
       Region 2vof B 154-155 disorder
 Evidence X-RAY 2vof D Reference
       Region 2vof D 130-131 disorder
       Region 2vof D 132-153 order
       Region 2vof D 154-155 disorder
SeqProS verified 130-155 Hetero dimer : Q07440
       Region 2vof B 131-153 order
       Region 2vof D 132-153 order
       Region 128-161 disorder
SeqProS verified 130-155 Hetero dimer : P97287
       Region 2roc B 130-155 order
       Region 128-161 disorder
 
Prediction
NeProc
Disorder 1-193
ProS 1-43,55-61,68-87,121-136,145-151,167-182
AlphaFold
Disorder 1-128,161-165,179-190,192-193
Order 129-160,166-178,191-191
SEG 42-71 ,73-95 ,153-164
Function
Function in SwissProt
Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (By similarity). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (By similarity). Regulates ER stress-induced neuronal apoptosis (PubMed:21159964, PubMed:22761832).