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IID50472
 UniprotQ9Z1X4
ProteinInterleukin enhancer-binding factor 3
GeneIlf3
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
898
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-381 Hetero dimer : Q9CXY6
 Evidence X-RAY 4at7 B Reference
       Region 4at7 B 1-5 disorder
       Region 4at7 B 6-54 order
       Region 4at7 B 55-86 disorder
       Region 4at7 B 87-340 order
       Region 4at7 B 341-353 disorder
       Region 4at7 B 354-374 order
       Region 4at7 B 375-381 disorder
 Evidence X-RAY 4at8 B Reference
       Region 4at8 B 1-4 disorder
       Region 4at8 B 5-54 order
       Region 4at8 B 55-86 disorder
       Region 4at8 B 87-183 order
       Region 4at8 B 184-184 disorder
       Region 4at8 B 185-187 order
       Region 4at8 B 188-192 disorder
       Region 4at8 B 193-340 order
       Region 4at8 B 341-353 disorder
       Region 4at8 B 354-369 order
       Region 4at8 B 370-371 disorder
       Region 4at8 B 372-373 order
       Region 4at8 B 374-381 disorder
 Evidence X-RAY 4at8 D Reference
       Region 4at8 D 1-5 disorder
       Region 4at8 D 6-55 order
       Region 4at8 D 56-86 disorder
       Region 4at8 D 87-189 order
       Region 4at8 D 190-194 disorder
       Region 4at8 D 195-340 order
       Region 4at8 D 341-353 disorder
       Region 4at8 D 354-366 order
       Region 4at8 D 367-368 disorder
       Region 4at8 D 369-370 order
       Region 4at8 D 371-371 disorder
       Region 4at8 D 372-373 order
       Region 4at8 D 374-381 disorder
 Evidence X-RAY 4at9 B Reference
       Region 4at9 B 1-5 disorder
       Region 4at9 B 6-55 order
       Region 4at9 B 56-86 disorder
       Region 4at9 B 87-182 order
       Region 4at9 B 183-191 disorder
       Region 4at9 B 192-340 order
       Region 4at9 B 341-352 disorder
       Region 4at9 B 353-365 order
       Region 4at9 B 366-381 disorder
 Evidence X-RAY 4atb B Reference
       Region 4atb B 1-5 disorder
       Region 4atb B 6-55 order
       Region 4atb B 56-86 disorder
       Region 4atb B 87-189 order
       Region 4atb B 190-193 disorder
       Region 4atb B 194-340 order
       Region 4atb B 341-353 disorder
       Region 4atb B 354-366 order
       Region 4atb B 367-368 disorder
       Region 4atb B 369-374 order
       Region 4atb B 375-381 disorder
 Evidence X-RAY 4atb D Reference
       Region 4atb D 1-5 disorder
       Region 4atb D 6-52 order
       Region 4atb D 53-86 disorder
       Region 4atb D 87-183 order
       Region 4atb D 184-184 disorder
       Region 4atb D 185-186 order
       Region 4atb D 187-194 disorder
       Region 4atb D 195-341 order
       Region 4atb D 342-353 disorder
       Region 4atb D 354-366 order
       Region 4atb D 367-381 disorder
Seq 393-592 Monomer :
 Evidence X-RAY 5dv7 C The construct of mouse NF90 used for crystallization and isothermal titration calorimetry (ITC) is NF90dsRBDs delta NLS, residues 393-592 (Figure 1A). Reference
       Region 5dv7 C 393-402 disorder
       Region 5dv7 C 403-467 order
       Region 5dv7 C 468-518 disorder
       Region 5dv7 C 519-590 order
       Region 5dv7 C 591-592 disorder
Seqphosphorylation
    477-477 Phosphoserine
    476-476 Phosphoserine
    384-384 Phosphoserine
    382-382 Phosphoserine
    315-315 Phosphothreonine; by PKR
    190-190 Phosphoserine
    188-188 Phosphothreonine; by PKR
    67-67 Phosphothreonine
    482-482 Phosphoserine
    486-486 Phosphoserine
    592-592 Phosphothreonine
    794-794 Phosphoserine
    812-812 Phosphoserine
    814-814 Phosphoserine
    818-818 Phosphoserine
Seqacetylation
    460-460 N6-acetyllysine
    100-100 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-5,52-86,185-190,342-398,465-524,602-898
Order 6-51,87-134,141-178,191-341,399-464,525-601
ProS 342-398,465-472,487-493,602-610,621-630,642-693,713-723,760-791,800-808,819-825,838-843,862-873,883-898
AlphaFold
Disorder 1-6,56-85,190-191,342-353,372-403,469-518,591-898
Order 7-55,86-189,192-341,354-371,404-468,519-590
Pfam Hmmer
402->465 94-342 528->588
SEG 95-115 ,375-396 ,490-508 ,573-588 ,638-688 ,691-725 ,745-769 ,777-807 ,810-886
Function
Function in SwissProt
RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response. Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs.