Search Keyword:


Search option:


IID50473
 UniprotQ9Z2D6
ProteinMethyl-CpG-binding protein 2
GeneMecp2
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
484
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 285-309 Hetero hexamer : Q8BHJ5
 Evidence X-RAY 5naf E Reference
       Region 5naf E 285-296 disorder
       Region 5naf E 297-307 order
       Region 5naf E 308-309 disorder
 Evidence X-RAY 5naf F Reference
       Region 5naf F 285-297 disorder
       Region 5naf F 298-307 order
       Region 5naf F 308-309 disorder
SeqProS possible 297-307 Residues 261-330 of human MeCP2 (UniProt ID: P51608), which are 99 % identical to those of the mouse ortholog, are shown to be disordered (PMID: 20405910; see IID00717). Hetero hexamer : Q8BHJ5
       Region 5naf E 297-307 order
       Region 5naf F 298-307 order
Seqphosphorylation
    13-13 Phosphoserine
    80-80 Phosphoserine
    424-424 Phosphoserine
    421-421 Phosphoserine; by CaMK2
    229-229 Phosphoserine
    216-216 Phosphoserine
    116-116 Phosphoserine
Seqacetylation
    447-447 N6-acetyllysine
    321-321 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-95,165-484
Order 96-164
ProS 1-11,91-95,205-228,254-257,267-274,295-303,308-318,336-347,457-461,467-484
AlphaFold
Disorder 1-91,163-171,174-174,176-222,224-224,226-385,389-399,401-479,482-484
Order 92-162,172-173,175-175,223-223,225-225,386-388,400-400,480-481
SEG 23-44 ,65-81 ,171-200 ,231-238 ,274-292 ,340-403
Function
Function in SwissProt
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).