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IID50474
UniprotV6CLJ5
ProteinSuppressor of hairless protein homolog
Genelag-1
OrganismCaenorhabditis elegans
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
790
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 309-780 Hetero trimer : IID50027Complex,IID50087Complex
 Evidence X-RAY 2fo1 A Reference
       Region 2fo1 A 309-311 disorder
       Region 2fo1 A 312-384 order
       Region 2fo1 A 385-394 disorder
       Region 2fo1 A 395-428 order
       Region 2fo1 A 429-435 disorder
       Region 2fo1 A 436-489 order
       Region 2fo1 A 490-496 disorder
       Region 2fo1 A 497-550 order
       Region 2fo1 A 551-556 disorder
       Region 2fo1 A 557-780 order
Seq 309-780 Hetero dimer : IID50027Complex
 Evidence X-RAY 3brd A Reference
       Region 3brd A 309-311 disorder
       Region 3brd A 312-380 order
       Region 3brd A 381-397 disorder
       Region 3brd A 398-421 order
       Region 3brd A 422-435 disorder
       Region 3brd A 436-490 order
       Region 3brd A 491-495 disorder
       Region 3brd A 496-549 order
       Region 3brd A 550-553 disorder
       Region 3brd A 554-778 order
       Region 3brd A 779-780 disorder
Seq 309-780 Monomer :
 Evidence X-RAY 1ttu A Reference
       Region 1ttu A 309-311 disorder
       Region 1ttu A 312-379 order
       Region 1ttu A 380-396 disorder
       Region 1ttu A 397-421 order
       Region 1ttu A 422-435 disorder
       Region 1ttu A 436-777 order
       Region 1ttu A 778-780 disorder
 
Prediction
NeProc
Disorder 1-25,60-313,370-396,403-408,421-437,481-497,639-644,784-790
Order 26-59,314-369,397-402,409-420,438-480,498-552,561-638,645-778
ProS 1-25,60-79,87-113,386-396,403-408,421-437,481-486,639-644,784-790
AlphaFold
Disorder 1-303,309-312,385-393,424-424,426-434,550-554,780-784,787-790
Order 304-308,313-384,394-423,425-425,435-549,555-779,785-786
SEG 13-25 ,97-114 ,121-145 ,170-186 ,189-210
Function
Function in SwissProt
Transcriptional regulator that plays a central role in lin-12/Notch and glp-1/Notch signaling pathways, involved in cell-cell communication that regulate a broad spectrum of cell-fate determinations (PubMed:8625826). Binds directly to the 5'-[A/G]TGGGAA-3' DNA consensus sequence, which is present in the regulatory region of several genes (PubMed:8625826, PubMed:18706403, PubMed:23615264, PubMed:15297877, PubMed:32196486, PubMed:21737278). Acts as a transcriptional repressor when it is not associated with Notch proteins (By similarity). When in a complex with a Notch intracellular domain (NICD) product of lin-12/Notch or glp-1/Notch, and transcription regulator lag-3, it may act as a transcriptional activator that activates transcription of target genes(PubMed:18381292, PubMed:10830967, PubMed:32196486, PubMed:9003776). Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively (By similarity). Autonomously required in the germline for the stem cell fate, acting in the glp-1-dependent transcriptional activation of genes, including lst-1 and sygl-1 (PubMed:32196486). Involved in cell-fate specification during reproductive system development, by positively autoregulating its own expression, in response to lin-12/Notch signaling (PubMed:23615264, PubMed:32839181). Plays a role in Notch-dependent induction of left-right asymmetry in interneurons and motoneurons (PubMed:21737278). May repress expression of hlh-6, in a lin-12/Notch-independent manner (PubMed:18706403).