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IID90047
UniprotP06463
ProteinProtein E6
GeneE6
OrganismHuman papillomavirus type 18
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
158
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-152 Hetero dimer : IID00209Complex
 Evidence X-RAY 6sjv A Reference
       Region 6sjv A 1-143 order
       Region 6sjv A 144-152 disorder
Seq 146-158 Hetero tetramer : P26045
 Evidence X-RAY 8oep B Reference
       Region 8oep B 146-147 disorder
       Region 8oep B 148-158 order
 Evidence X-RAY 8oep D Reference
       Region 8oep D 146-152 disorder
       Region 8oep D 153-158 order
Seq 149-158 Hetero tetramer : Q14160
 Evidence X-RAY 8b82 C Reference
       Region 8b82 C 149-150 disorder
       Region 8b82 C 151-158 order
 Evidence X-RAY 8b82 D Reference
       Region 8b82 D 149-158 order
Seq 149-158 Hetero dimer : IID00520Complex
 Evidence X-RAY 4jor C Reference
       Region 4jor C 149-158 order
 Evidence X-RAY 4jor D Reference
       Region 4jor D 149-153 disorder
       Region 4jor D 154-158 order
 Evidence X-RAY 5ic3 C Reference
       Region 5ic3 C 149-152 disorder
       Region 5ic3 C 153-158 order
 Evidence X-RAY 5ic3 D Reference
       Region 5ic3 D 149-154 disorder
       Region 5ic3 D 155-158 order
 Evidence X-RAY 5k4f C Reference
       Region 5k4f C 149-152 disorder
       Region 5k4f C 153-158 order
 Evidence X-RAY 5k4f D Reference
       Region 5k4f D 149-154 disorder
       Region 5k4f D 155-158 order
Seq 152-158 Hetero tetramer : IID00061Complex
 Evidence X-RAY 6zfg A Reference
       Region 6zfg A 152-158 order
 Evidence X-RAY 6zfg B Reference
       Region 6zfg B 152-158 order
Seq 152-158 Hetero dimer : Q62696
 Evidence X-RAY 2i0i D Reference
       Region 2i0i D 152-152 disorder
       Region 2i0i D 153-158 order
 Evidence X-RAY 2i0i E Reference
       Region 2i0i E 152-152 disorder
       Region 2i0i E 153-158 order
 Evidence X-RAY 2i0i F Reference
       Region 2i0i F 152-152 disorder
       Region 2i0i F 153-158 order
Seq 152-158 Hetero dimer : Q62696
 Evidence X-RAY 2i0l C Reference
       Region 2i0l C 152-152 disorder
       Region 2i0l C 153-158 order
 Evidence X-RAY 2i0l D Reference
       Region 2i0l D 152-153 disorder
       Region 2i0l D 154-158 order
Seq 152-158 Hetero tetramer : Q6RHR9
 Evidence X-RAY 2i04 C Reference
       Region 2i04 C 152-153 disorder
       Region 2i04 C 154-158 order
 Evidence X-RAY 2i04 D Reference
       Region 2i04 D 152-158 order
Seq 152-158 Hetero tetramer : IID00061Complex
 Evidence X-RAY 6zfd A Reference
       Region 6zfd A 152-158 order
 Evidence X-RAY 6zfd B Reference
       Region 6zfd B 152-158 order
SeqProS possible 153-158 PDZ domain-binding regions of HPV16-E6 (RRETQL) and HPV51-E6 (RNETQV) are verified ProS. Hetero dimer : IID00520Complex
       Region 4jor C 149-158 order
       Region 4jor D 154-158 order
SeqProS possible 153-158 PDZ domain-binding regions of HPV16-E6 (RRETQL) and HPV51-E6 (RNETQV) are verified ProS. Hetero dimer : Q62696
       Region 2i0l C 153-158 order
       Region 2i0l D 154-158 order
SeqProS possible 153-158 PDZ domain-binding regions of HPV16-E6 (RRETQL) and HPV51-E6 (RNETQV) are verified ProS. Hetero dimer : Q62696
       Region 2i0i D 153-158 order
       Region 2i0i E 153-158 order
SeqProS possible 153-158 Phospho-PBM (PDZ domain-binding motif) sequences with a 14-3-3-binding motif III; PDZ domain-binding regions of HPV16-E6 (RRETQL) and HPV51-E6 (RNETQV) are verified ProS. Hetero tetramer : IID00061Complex
       Region 6zfd A 152-158 order
       Region 6zfd B 152-158 order
SeqProS possible 153-158 PDZ domain-binding regions of HPV16-E6 (RRETQL) and HPV51-E6 (RNETQV) are verified ProS. Hetero tetramer : P26045
       Region 8oep B 148-158 order
       Region 8oep D 153-158 order
SeqProS possible 153-158 Phospho-PBM (PDZ domain-binding motif) sequences with a 14-3-3-binding motif III; PDZ domain-binding regions of HPV16-E6 (RRETQL) and HPV51-E6 (RNETQV) are verified ProS. Hetero tetramer : IID00061Complex
       Region 6zfg A 152-158 order
       Region 6zfg B 152-158 order
SeqProS possible 153-158 PDZ domain-binding regions of HPV16-E6 (RRETQL) and HPV51-E6 (RNETQV) are verified ProS. Hetero tetramer : Q6RHR9
       Region 2i04 C 154-158 order
       Region 2i04 D 152-158 order
 
Prediction
NeProc
Disorder 1-5,150-158
Order 6-149
ProS 150-158
SEG 144-155
Function
Function in SwissProt
Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6AP targets several other substrates to degradation via the proteasome including host DLG1 or NFX1, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including BAK1, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.